Organised by: Co-Sponsored: Malaysian Healthy Ageing Society
Workshop Okinawan Lifestyle- Then and Now Makoto Suzuki, M.D.& Ph.D. Makoto Suzuki, M.D.& Ph.D. Professor Emeritus, University of the Ryukyus Professor Emeritus, University of the Ryukyus Chief Director, Okinawa Research Center for Longevity Science Chief Director, Okinawa Research Center for Longevity Science President, Okinawa Health and Longevity Research and Development Center President, Okinawa Health and Longevity Research and Development Center
Discussion Items 1. Regional longevity indices 2. Biomedical analysis for longevity 3. Okinawa way (program) 4. Longitudinal cohort study of Okinawa way 5. Dark sign of Okinawa longevity 6. Not longevity but chouju
Discussion Items 1. Regional longevity indices 1) Average life expectancy 2) Centenarian’s rate
All Cause Mortality in Okinawa and Japan 20000 Mortality per 100,000/yr O K I N A W A 15000 J A P A N 10000 5000 0 60-64 65-69 70-74 75-79 80-84 85- stratum Age Group
Q ui uinta tannua ual tr trend of average life expecta tancy betw tween O kinawa wa and Japan 90 88 86 84 Female Okinaw 82 years old Female Japan 80 Male Okinawa 78 Male Japan 76 74 72 70 1975 1980 1985 1990 1995 2000 2005
Biannual years trend of centenarians rate (1/10 5 ) between Okinawa and Japan （ 1970 ～ 2006 ） 60.00 Okinawa 50.00 40.00 Okinawa ◆ 割 沖縄 30.00 Japan ■ 合 日本 20.00 Japan 10.00 0.00 1970 1972 1974 1976 1978 1980 1982 1984 1986 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 年
Discussion Items 1. Regional longevity indices 2. Biomedical analysis for longevity
Personal survey design on the spot ① • Background life history Birth, school, wedding • Family history (pedigree) • Social background Occupation , finance ,religion • Anthropometric • Character • Past medical history
Personal survey design on the spot ② • Present physical and mental status • Clinical examinations Urinalysis , Blood analysis , Stool tests , ECG , PWV , Echogram , EEG , MMSE
Comprehensive Clinical Charts of Okinawa Centenarians (1976-2011)
Prevalence of ＨＬＡｰＤＲ９ and ＤＲ 1 in Okinawa Centenarian 人 百 82 CE P＜0.0005 ＤＲ９ 対159 フ SE ェ phenotype ノ タ イ プ CE 百 82 ＤＲ1 P＜0.005 対159 SE ％ 0 10 10 20 20 30 30 40 40 Centenarian septuagenarian CE SE
μ ｇ / dl μ ｇ / dl μ ｇ / dl μ ｇ / dl μ ｇ / dl μ ｇ / dl Age fluctuation of Serum DHEA-S (F) Age fluctuation of Serum DHEA-S (F) Age fluctuation of Serum DHEA-S (F) Age fluctuation of Serum DHEA-S (F) Age fluctuation of Serum DHEA-S (F) Age fluctuation of Serum DHEA-S (F) Age fluctuation of Serum DHEA-S (F) YO YO YO YO YO YO DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone sulfate sulfate sulfate sulfate sulfate sulfate sulfate
Age fluctuation of Age fluctuation of Age fluctuation of Age fluctuation of ★ Male ★ Male ★ Male ★ Male DHEA-S and Cortisol DHEA-S and Cortisol DHEA-S and Cortisol DHEA-S and Cortisol ★ Female ★ Female ★ Female ★ Female DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone DHEA-S : Dehydro epiandrosterone sulfate sulfate sulfate ★ ★ ★
“Japanese Centenarian” Medical research for the final stage of the human aging
Discussion Items 1. Regional longevity indices 2. Biomedical analysis for longevity 3. Okinawa way (program)
Various overseas versions of “Okinawa Program”
Four main items for successful longevity (Okinawa Program) 1.Dietary Culture 2. Physical Activity 3. Self-Help Manner 4. Mutual Help Custom
Four main items for successful longevity (Okinawa Program) 1. Dietary Culture
Goya champloo, stirfried bitterguard with soybean curds
Boiled sponge cucumber with soybean paste
Boiled porkchops with skin, seaweed and konjak with soy sauce <Cooking way> Traditional Modern (pot, simmer) (microwave) Collagen cholesterol elastin triglyceride
Four main items for successful longevity 1. Dietary Culture 2. Physical Activity
Original of his income and joy Seiryu Toguchi in his farm M 102 years old
Four main items for successful longevity 1. Dietary Culture 2. Physical Activity 3. Self-Help manner for physical, mental, social and spiritual independence, （ health ） by keeping worthiness of one’s life and lasting lively role for one’s family and society
Thorough Medical check up in Medical examination cars
Ugan : Praying in front of the family altar niching her ancestor’s memorial tablets, put her hands together, expressing reporting her family daily events expressing her thanks and asking divine protection and prosperity for her family. Keep one’s role for her family
Four main items for successful longevity 1. Dietary Culture 2. Physical Activity 3. Self-Help manner 4. Mutual Help Custom
Reaping sugar canes by vicinity joint scheme in the village community farm
Get-together meeting for their friendship and mutual help, class reunion of 88 years old elementary school graduates
Discussion Items 1. Regional longevity indices 2. Biomedical analysis for longevity 3. Okinawa way (program) 4. Longitudinal cohort study of Okinawa way
Okinawa Life Experience Seminar
Cooking steamed rice with mugwort by Okinawa life experience seminar
Morning Exercise
Meditation Practice
Past 1 year Changes of Biomarker levels in Cohort Group at Okinawa Life Intervention significant Past 1 year difference Pre- （ n ＝ 5 ） Standard level period M :140-2240 DHEA-S (ng/mL) 1738.6 ± 752.37 1696.6 ± 570.57 n.s. F: 50-1000 45.00 ± 4.35 29.90 ± 5.18 p ＜ 0.05 M 20-59 Estradiol （ pg/mL ） 25-350 （ end of follicular phase ） 15.75 ± 2.48 10.00 以下 F n.s. 9-230 （ luteal phase ） ― SOD Activity （ U/mL ） 4.00 ± 3.08 4.48 ± 3.24 n.s. Homocystine （ nmol/ ｍ L) 10.52 ± 2.55 10.72 ± 2.11 n.s 3.0-14 Total Hydroxyproline （ μmol/L ） 48.60 ± 3.50 43.00 ± 4.18 ― n.s. Free Hydroxyproline （ μmol/L ） 11.77 ± 3.83 9.6 ± 3.91 ― n.s. DHEA-S : Dehydro epiandrosterone sulfate SOD : Superoxide dismutase
Discussion Items 1. Regional longevity indices 2. Biomedical analysis for longevity 3. Okinawa way (program) 4. Longitudinal cohort study of Okinawa way 5. Dark sign of Okinawa longevity
Dark sign of Okinawa Longevity 1. Increased of Obesity 2. Increased of Dependent elderly
Dark sign of Okinawa Longevity 1. Increased of Obesity
Mortality rate differences between Japan and Okinawa in 2000 by sex and every 20 years-of-age stratum （ Nr./10 5 ） Okinawa (male) Japan (male) Okinawa (female) Japan (female) (Years of age)
Time Trend BMI 70 yrs and older between Okinawa and Japan 25 24 23 Female Okinawa 22 Female Japan Male Okinawa 21 Male Japan 20 19 18 1949 1975 2000 Reference : Okinawa Prefectural Government
Dark sign of Okinawa Longevity 1. Increased of Obesity 2. Increased of Dependent elderly
Decennial trend of of Total ADL Scores among Centenarians 1970’s n=43 ※ 1980’s ※ n=99 ADL平均値 ※※ 1990’s n=109 2000’s n=99 (2000-04) 0 10 20 30 40 50 60 ADL scores Decrease of healthy and active, ※ p ＜ 0.01 increase of unhealthy and frail due to improved medical care. ※※ p ＜ 0.005
Discussion Items 1. Regional longevity indices 2. Biomedical analysis for longevity 3. Okinawa way (program) 4. Longitudinal cohort study of Okinawa way 5. Dark sign of Okinawa longevity 6. Not longevity but chouju
Not longevity but chouju Chouju 長寿 Longevity • Prolongation of • Celebration of long length of life life • Quantity of life • Quality of life • Old men • Elderly • How to extend • How to celebrate “Chronos” “Kiros”.
Longevity → Length of life （ Chronos ） Mindfulness and Implementation of own role Maintenance Ikigai Worthy of life Chouju → High QOL （ Kairos ）
Society of new elder citizens, president Dr. S.Hinohara 100y’s old
Five slogans of New elder movement 1. Independence by succession of traditional culture and well life style 2. World peace by activation of war experience 3. Contribution for Med. Research by offering health information 4. Communication for society members 5. Praise for nature and promotion of worthy life
Lecture “Ikigai”,Meaning of life by Dr. S.Shouchi(104 ys’ old)
Interview and discussion between Dr. S.Shouchi and Professor L.Poon
Stand and walk on his head,92 years old Decathlon Worthiness of life
Panoramic view from Katsuyama farm, Nago, Okinawa
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