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LFS Research Caf Eating the right foods to prevent disease How - PowerPoint PPT Presentation

Oct 09, 2023 •115 likes •390 views

LFS Research Caf Eating the right foods to prevent disease How your diet impacts DNA and gene functioning, and the link to long-term health outcomes Dr. Barbara Stefanska Assistant Professor Faculty of Land and Food Systems Todays

  1. LFS Research Café Eating the right foods to prevent disease How your diet impacts DNA and gene functioning, and the link to long-term health outcomes Dr. Barbara Stefanska Assistant Professor Faculty of Land and Food Systems

  2. Today’s Presentation • Chronic disease and modifiable risk factors • Epigenetic alterations as a contributor to chronic disease • Impact of diet on the epigenome • Diet as a factor shaping our health and health of next generations

  3. Food insecurity Chronic disease in Canada

  4. Food insecurity Direct health care costs: $70 billion a year Chronic disease + in Canada Indirect cost: $55 billion a year from loss of productivity and foregone income

  5. Chronic disease Food insecurity risk factors

  6. Chronic disease Food insecurity modifiable risk factors Epigenetics!

  7. Blue – Normal Red - Cancer Color key and histogram genes Altered -2 2 epigenetic patterns in chronic disease Liver

  8. Twins

  9. Lamarck got it right

  10. Epigenetics & gene functioning AcAc AcAc AcAc Me Me Me Me AcAc AcAc AcAc Condensed chromatin Open chromatin Gene silenced Gene expressed

  11. Dynamics of epigenetic modifications Diet Abusive behaviour Viral infections Me Me Me Me Temperature Social-Economic Status Ac Ac Ac Ac Ac Ac Radiation Maternal care Ac Ac Ac Ac Ac Ac Chemicals

  12. SAM, the methyl donor Nutrition & Recruitment Recruitment the epigenome

  13. SAM reshapes the epigenome Ctrl and protects from bone SAM metastasis

  14. Bioactive compounds Disease prevention Genistein Anthocyanins Curcumin (turmeric) Epigallocatechin Gallate Lycopene Pterostilbene Quercetin Organosulfides Vitamin A (ATRA) Vitamin D (D3: Calcitriol) Resveratrol Sulforaphane

  15. Bioactive compounds Disease prevention Pterostilbene Resveratrol

  16. Grapes and blueberries: Disease Prevention through epigenetics

  17. Grapes and blueberries: DNA-interacting proteins responsible for epigenetic activity

  18. Healthy cells respond to foods through changes in the epigenetic patterns

  19. Diet and health of future generations Diet Environment Epigenetics Lifestyle

  20. Predisposition of the Gestational diabetes offspring to diabetes Epigenetic silencing of Leptin Diabetes type 2 in the offspring

  21. Leptin as a guardian of body weight

  22. Gestational Inappropriately diabetes and low leptin epigenetics secretion for a given fat mass of leptin gene Decrease in expression through hypermethylation

  23. Project Ice Storm Quebec 1998

  24. Project Ice Storm Quebec 1998

  25. Animal models to track epigenetic effects

  26. Woah, it’s the end already. Questions? Comments? barbara.stefanska@ubc.ca

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