Key principles • No drug or alternative therapy is cheap • No cost effectiveness if not effective, not safe if not evaluated • Ingredients vary, as does quality, price and consistency • Patients love natural, organic, home-remedy, old- fashioned ‘cures’ • Beware the well meaning (daughter/son) or ‘HCP’ next door • Best approach is: • Get patient to report these alongside other meds (“bring the shopping bag”) • Outline what is known / harmful from what is unknown • Have patient do the homework – websites, labels, ingredients • Trust is everything – don’t ignore
What is Complementary / Alternative Medicine? • “Complementary” and “alternative” are not interchangeable • “Complementary” generally refers to using therapy together with conventional medicine. • “Alternative” refers to using a therapy instead of conventional medicine. • In Canada, use of alternative medicine is not common • The boundaries between complementary and conventional medicine overlap and change with time. NCCIH: https://nccih.nih.gov/health/integrative-health
CAM includes 1. Systems of care: • Traditional Chinese medicine • Ayurvedic medicine 2. Natural health products / functional foods • Minerals, vitamins, herbs, lotions, potions, cocktails 3. Practices • Mindfulness, massage • Heterogeneity in quality • Multiple species, Growing conditions, Plant part, Extraction method • Characterization, not standardization • NNHPD: Good Manufacturing Practices and “ truth in labeling ” • Pharmacology and mechanisms of action largely unknown
NHP and Safety • NHP-drug interaction tool Absence of information In vitro or in vivo Theoretical Clinical AE Emerging clinical evidence Clinical evidence documenting the lack of interaction after concurrent use Kutt et al. Can Pharm J. 2016
• Articles • PubMed www.ncbi.nlm.nih.gov/pubmed/ • Use the Complementary Medicine limit • Cochrane (systematic reviews) www.cochrane.org • Browse by the topic of Complementary Medicine • Synthesized information • Natural Medicine (available from UofA Libraries) • Natural Medicines Comprehensive Database (available from UofA Libraries) • NCCIH: https://nccih.nih.gov/health/integrative-health
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