Investor Presentation Stock Code ： 1789.HK 03.2020 1
Overview Contents Business Review Financial Review Strategic Objectives Appendix Q&A Session 2
Overview 3
Overview The First A-series Hip JPX Knee Founded in Beijing Start M-series Hip The first product - AK Knee Introduce 3D-printing technology to • joint implants 3D ACT Physician – Technician Interaction Platform Hip Revision series • “PTIP” Obtained first NMPA registration certificate for 3D • A3 Knee System AK Hip product is identified as a • - printed acetabula cup; Revision Knee System - ACCK National-level key new product • Authorized to set up Beijing Engineering • Technology R&D Center for 3D Printing Application in Orthopedics; Listed on Hong Kong Stock Exchange Obtained NPMA registration certificate for ceramic • to HXLPE Obtained two NMPA registration certificates for 3D- • Won the First Prize of Beijing Science and Technology • Changzhou Facilities (ITI • printed spinal products; Award; Medical) commenced into Received the national special funds of the 13th • Full acquisition of JRI; operation • five-year plan; A3 knee joint system clearance by FDA; • 3D printed artificial pelvis • Set up ITI Medical (Changzhou facility) • system launched 4
At a Glance No. 1 299 ＞ 30% Market share among all joint brands in terms of volume Domestic brand with the Compound growth most patents in joints rate over a decade 18.3% Market share among all joint brands in terms of value 12.2% 9.3% 6000+ 7.5% 51 NMPA Number of covered Domestic brand with the most hospitals certificates in joints 2018 2019 2017 5
At a Glance Obtained CE marks for 3D printed cages • Postdoctoral Workstation Hip system • The largest 3D-printing collaborative with Peking Knee system • center for metal University orthopedic implants in the Asia-Pacific region Customized The first to file 3D-printed customized prosthesis; China's first joint product clearance 5 3D-printed customized medical devices filed CNAS Mechanics laboratory by FDA: A3 knee system (Joint, thoracolumbar fusion, cervical fusion) 6
Our Portfolio Others 3.1% 3D-printed Products Hip System 13.3% （ Non 3D printing ） 58.8% Revenue Structure Cups Cages Artificial Artificial Vertebral Pelvis Body System Hip implants Knee implants Knee System 3D-printing products Others 24.8% 7
Business Review 8
R&D R&D Achievements 35 4 12 32 Class Ⅲ / 3 calss II Class Ⅲ 2 NMPA class Ⅲ / 10 CE AK Beijing JRI ITI 69 2 228 Authorized Authorized Authorized Invention Patents Utility Model Patents PCT 9
R&D: TECHNOLOGIES Advanced technology with the comparable level of MNC Bone Surface Interface Friction Fixation 3D Coating C-XLPE C-C Printing Porous HA Ti trabecular structure High-end The first 3D-printed metal orthopedic implants approved by NMPA and Global advanced coating technology: commercialized in China ； Friction interfaces of C-C and C-XLPE; Vacuum plasma sprayed HA coatings ； • The porous trabecular structure solves the problem of bone ingrown; Synchronized technology with MNC. Vacuum plasma sprayed Ti coatings ； • 3D-printed augment system provides a solution to large acetabular bone Improve the roughness, porosity and biological activity of defects; 10 10 the implant surface . Propound the theory of acetabular revision.
R&D: TECHNOLOGIES Rich product lines and ability of dealing with complicated diseases Provide products for knee/ hip/ spine/bone tumor and personalized surgical tools; Provide services with digital technology to solve orthopedic clinical problems; Provide full solutions - from primary to complex, from revision to bone tumor reconstruction The 3D-printed customized thoracic spine produced by the Company was implanted successfully during an operation at Peking University Third Hospital on 9 January 2020. 11
R&D: TECHNOLOGIES One-stop 3D ACT PTIP → → → → → → → Pre-surgery selected Surgical Precision Input as the 3D imaging implants CT or MRI simulation implants and database on and and scanning surgeries the PTIP modeling Personalized planning instruments PTIP Developed 3D ACT PTIP, which provides personalized 3D ACT solutions to the surgeons and patients. As of December 31 , 2019, the platform has served 964 hospitals ( 142 more than in 2018), 590 of which are Class III hospitals. 4,741 cases have been designed. 12
R&D Product pipelines I Product Name Application Features Expected Launch Date 3D around the hip Patient matched customization,3D Bone destruction and defect reconstruction around hip joint Q2 2020 reconstruction implants printed Patient matched customization,3D Q2 2020 3D pelvic sacrum implants Reconstruction of pelvic sacrum, nail-rod combination printed Patient matched customization,3D Q3 2020 3D cervical spine Trauma, tumor destruction, cervical spine reconstruction printed Q2 2020 3D hemipelvis revision system Pelvic tumor defect reconstruction and structural support Customized,3D printed 3D Printed 3D cervical lamina implant Cervical spondylosis, Spinal canal enlargement Customized,3D printed Q3 2020 system Multi-stage thoracolumbar reconstruction Customized,3D printed Q3 2020 3D Thoracolumbar spine 3D Knee joint reconstruction Bone destruction and defect reconstruction around the knee Q4 2020 Customized,3D printed implants joint For severe trauma, tumor bone destruction, defect 3D Long limb bone implants Customized,3D printed Q4 2020 reconstruction For patellofemoral compartment disease, early treatment of 3D patellofemoral implants Customized,3D printed 2023 knee joint disease 13
R&D Product pipelines II Product Name Application Features Expected Launch Date 3D printed self-stabilizing Q2 2020 Cervical spine fusion, low notch 3D printed, standardized cervical interbody cage Severe bone defect of knee joint, complicated Q4 2020 TMK knee implants system 3D printed, standardized primary surgery and revision Knee joint bone defect support Q4 2020 Suitable for focal knee bone defects 3D printed, standardized system 3D Printed 3D printed shoulder joint 2026 Suitable for shoulder joint replacement 3D printed, standardized implants 2 nd generation 3D technology, 3D + 2024 Lumbar fusion cage For lumbosacral fusion bio-compound, standardized 2 nd generation 3D technology, 3D + Cervical spine fusion device For cervical interbody fusion 2024 bio-compound, standardized Proximal biological fixation, distal anti- Cone Biostem System Primary and revision hip replacement surgery Q2 2020 rotational stabilization ABM anatomical revision handle For revision hip replacement surgery Anatomical design, biological fixation Q2 2020 system Joints Femoral fixation system Suitable for revision hip replacement surgery Upgrade of traditional products Q2 2020 Titanium plasma biological coating. Biological acetabular system Suitable for initial hip replacement surgery Q3 2020 One cup, multi-lined combined 14 design
R&D Product pipelines III Product Name Application Features Expected Launch Date Titanium plasma biological coating; Biological femoral stem Q4 2020 For initial hip replacement surgery Bone retention anti-rotational system design Can be used with ceramic ball Bone cement femoral stem Suitable for initial hip replacement surgery 2021 heads; Bone retention anti- system rotational design Dual-coated Bio-type Femoral 2021 Hip replacement Titanium + HA coating Stem Unicompartmental knee Unicompartmental Knee Unilateral compartment knee replacement surgery replacement; retain more bone, 2023 Joints less trauma, and faster recovery Double biological coating, Anti- Bi-dynamic acetabular oxidation and wear-resistant, 2024 Suitable for initial hip replacement surgery system double action system, the elderly, easy dislocation Embedded surface knee Minimally invasive, retain more Local osteonecrosis and cartilage repair 2025 prosthesis bone, early treatment Bone preservation, young patients’ 2025 New Surface Hip Prosthesis Hip disease patients with high active demand International cooperation Anterior cervical internal Q1 2020 Anterior cervical spine fusion ， and assist cervical stabilization Upgrade of traditional products fixation plate system Spines Chest, waist and / or sacral posterior spinal fixation to assist Q2 2020 Spinal fixation system Upgrade of traditional products spinal stabilization 15
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