Integration of classifications and terminologies in metadata - PowerPoint PPT Presentation

These sheets are only for use in connection with the speech. Integration of classifications and terminologies in metadata registries based on ISO/IEC 11179 Sylvie Ngouongo Jürgen Stausberg Ludwig-Maximilian-University of Munich, Germany Institute of Medical Informatics, Biometry and Epidemiology (IBE) Presented by Sylvie Ngouongo

Agenda • Introduction • Objectives • Material – ISO/IEC 11179 V3 – Classifications and Terminologies • Methods and Results – Mapping – Import • Discussion • Conclusion MIE 2011, Sylvie Ngouongo 2

Introduction • Empirical medical research – is based on the collection of observations stored in DBMS; – needs services for the maintenance of item collections and improvement of semantic interoperability: • Reuse of item`s definitions • Quality improvement through harmonization and standardization, • Integration and use of controlled vocabularies as value lists for items. • MDR-Project in Germany launched in 2009 by the Federal Ministry of Education and Research to set up a national Metadata repository for the support of empirical research. – ISO/IEC 11179 V3 MIE 2011, Sylvie Ngouongo 3

Objectives • Appropriateness of ISO/IEC 11179 V3 “Information technology - Metadata Registries (MDR)” part 3 “Registry Metamodel and basic attributes” for a national MDR in Germany. • Possibilities of including well-established classifications and terminologies (controlled vocabularies) using the metamodel of ISO/ IEC 11179 V3. MIE 2011, Sylvie Ngouongo 4

Material: ISO/IEC 11179 V3 Data Description Package • ISO/IEC 11179 describes the method of standardizing and registering of data elements to make data understandable and sharable. Object_Class Characteristic person sex 0..1 0..1 * * Data_Element_Concept Conceptual_Domain * 1 karyotype ¡ gender <men|women> 1 1 concept layer representation layer * * Data_Element Value_Domain gender ¡<male|female> <male|female> * 1 Data Description Package with examples in grey MIE 2011, Sylvie Ngouongo 5

Material: ISO/IEC 11179 V3 Concept Metamodel Region Concept_System Metamodel Region Classification Metamodel Region MIE 2011, Sylvie Ngouongo 6

Material: Classifications and Terminologies • ICD-10-GM : International Statistical Classification of Diseases and Related Health Problems 10th Revision German Modifications • OPS : German procedure classification • The TNM classification of malignant tumors: a well-established standard for the classification of malignant tumors in oncology. the TNM-system classification provides three axes for post-coordination (T: local tumor, N: regional lymph nodes, M: metastasis). • MedDRA : Medical Dictionary for Regulatory Activities, the international medical terminology used to classify adverse events associated with the use of biopharmaceuticals and other medical products. • SNOMED-CT : Systematized Nomenclature of Medicine-Clinical Terms, a multilingual clinical healthcare terminology, essential for electronic health records. MIE 2011, Sylvie Ngouongo 7

Material: Classifications and Terminologies - ClaML • Classification Markup Language (ClaML) is attractive as interface standard for the import of classifications (ICD-10-GM, OPS) into the MDR. • ClaML: EN 14463:2007, Standard for electronic representation of classification coding schemes. <?xml version="1.0" encoding="utf-8"?> <!DOCTYPE ClaML SYSTEM "claml.dtd"[]> <ClaML version="2.0.0"> <Meta name="TopLevelSort" value="I II III IV V VI VII VIII IX X XI XII XIII XIV XV XVI XVII XVIII XIX XX XXI XXII" /> <Meta name="lang" value="en" /> <Meta name="titleLong" value="International Statistical Classification of Diseases and Related Health Problems 10th Revision"/> <Identifier authority="WHO" uid="SRFSFto be added later" /> <?xml version="1.0" encoding="utf-8"?> <!DOCTYPE ClaML SYSTEM "claml.dtd"[]> <ClaML version <Meta name="TopLevelSort Title 2.0.0"> XIII XIV XV XVI XVII XVIII XIX XX XXI XXII < ="I II III IV V VI VII VIII IX X XI XII Meta name="lang" value="en" <Meta name="titleLong" B27.0 /> of Diseases and Related Health Problems 10th Revision"/> <Identifier authority value="International Statistical Classification ="WHO" uid="SRFSFto be added later" =" /> <Title ="2008-05-13 name="ICD-10-2008-EN" version=" < 2008" /> Class code="B27 ClaML and its structure´s elements " kind=" < category"> 8 Small excerpt of ClaML

Methods • Mapping – Approach and results • Import – Approach and results MIE 2011, Sylvie Ngouongo

Mapping: the approach • Mapping of ClaML Elements to elements of ISO/IEC 11179 V3 Metamodel. • Mapping of vocabularies structures to elements of the ISO/ IEC 11179 V3 metamodel. If 1b and 1a, then ClAML 1b 1c is possible Structure Mapping ISO 11179 V3 1a 1c representation 2 Structure Mapping ICD-10, OPS MIE 2011, Sylvie Ngouongo 10

Mapping : the results ClaML.root; ICD-10-GM; OPS; Concept_System Metamodel Region TNM; MedDRA; SNOMED-CT (Vocabularies) Classification Metamodel Region Classification´s semantic Example of ICD-10 ClaML-Classes / Intestinal infectious Vocabularies-Classes Diseases (A00-A09) generalization Hierarchy is_a specialization Cholera ClaML-Classes / MIE 2011, Sylvie Ngouongo (A00) 11 Vocabularies-Classes

Import: approach and results MIE 2011, Sylvie Ngouongo 12

Discussion • Representation of classifications and terminologies as sources for value lists of items is quite simple in ISO/IEC 11179 V3, however… – Terminologies (MedDRA, SNOMED-CT) could be easily represented both in the Concept Metamodel Region and the Data Description Package of ISO/IEC 11179 V3, – Representation of Classifications (ICD-10, OPS, TNM) in the Data Description Package ist not satisfactory yet, – Classifications´rules (inclusions, exclusions…) and exceptions could not be properly mapped in the Concept Package yet. • Full coverage of the item semantic is not reached yet, Implementation on logic level of application needed. • Different interpretations and extensions of the ClaML-Standard: DIMDI (ICD-10-GM 2010) vs. WHO (ICD-10-CM 2008). MIE 2011, Sylvie Ngouongo 13

Discussion • Example of discrepancies between WHO and DIMDI regarding ClaML WHO applies <Modifier> (subclassifications´coding) for 4-digit ICD-Classes to their superclasses (3- digit classes) whereas DIMDI applies them to the corresponding 4-digit classes to build the 5-digit subclassifications. M01 (3-digit) à M01.0 (4-digit) à M01.00 (5-digit) WHO DIMDI <Class code="M01" kind="category" usage="aster"> <Class code="M01" kind="category" usage="aster"> <SuperClass code="M00-M03" /> <SuperClass code="M00-M03"/> <SubClass code="M01.0" /> <SubClass code="M01.0"/> < code <SubClass code="M01.1" <SubClass code="M01.1"/> =" M01" kind="category" usage "> <SubClass code="M01.2"/> <Class code="M01 <SuperClass code=" /> < category" usage="aster"> SuperClass < <SubClass code="M01.0" /> code <SubClass code SubClass code="M01.1" /> <SubClass ="M00-M03"/> code =" M01.2" /> < <Class code="M01.0" kind="category" usage="aster"> ModifiedBy all=" <SuperClass code="M01"/> <Class code="M01.0" kind="category" usage="aster"> <ModifiedBy all="true" code="S13M00_5"/> <SuperClass code="M01" /> <Rubric kind="preferred"> <Rubric id="D0010244" kind="preferred"> <Class code="M01.0" kind=" <Class code <Label xml:lang <Label xml:lang="en" xml:space=" < category" usage="aster ="M01.0" kind=" "> category" usage=" <SuperClass aster"> </ Class code =" M01 14 <

Conclusion • ISO/IEC 11179 V3 is powerful and contributes many useful ideas for the definition of a national MDR. • An extension of ISO/IEC 11179 V3 metamodel to meet the predefined needs of a national MDR might be necessary. • A unique interpretation of ClaML by Healthcare organizations (WHO, DIMDI, …) is essential to continue work on the ClaML import interface. MIE 2011, Sylvie Ngouongo 15

Acknowledgements The presented work is part of the project MDR - Metadata Repository funded by the German Federal Ministry of Education and Research (BMBF). MIE 2011, Sylvie Ngouongo 16