Institute for Nuclear Research and Nuclear Energy: Present and Future Prof. Dimitar Tonev Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of Sciences
INRNE-BAS TODAY The biggest complex centre in Bulgaria for scientific and application investigations in the fields of: Nuclear physics Nuclear energy, nuclear methods and technologies High energy physics Radiation environment and ecology Theoretical and mathematical physics The research reactor of the INRNE-BAS Basic environmental observatory at peak Moussala Cyclotron laboratory World recognized results of the INRNE notified during the European Science Foundation evaluation of the BAS.
Pro rof. Eli lisaveta Karamihailo lova (1 (1897-1969) Pio ioneer of f th the Experimental Nucle lear r Physics in in Bulg lgaria
The group of Acad. W. Andrejtscheff is the world leader in the field of lifetime measurements!
THOMSON REUTERS On 18 june 2015 Thomson Reuters awards INRNE with first place for Essential Science Indicators for highly cited, top and hot papers .
Bulgaria si since 1999 Member State of f CERN Member of f CMS si since 1991, CMS MoU si signed in in 1999
Scientists fro from IN INRNE are re actively participating in in Ex Experiments of f sy synthesis of f su super-heavy ele lements at t th the Nuclear Reaction Lab at t JI JINR-Dubna, Russia
Astroparticle physics, ground based gamma-ray astronomy of very high energies INRNE is an official member of the big international collaboration MAGIC (Major A tmospheric G ama I maging C erenkov telescope) since 2005 via the Laboratory of Particle and Astroparticle Physics Scientific goals of MAGIC experiment: • Discovery of the origin and acceleration mechanisms of Cosmic rays • Search for Dark Matter, testing the fundamental laws and cosmological models • Discovery of new very high energy gamma-ray sources and detailed investigation of known ones
IRT-200 Mission EDUCATION Nuclear energy, technology and investigations Dosimetry, radiation protection Physics, radiochemistry and radiobiology Nuclear safety Applications Neutron activation analysis Production of isotopes Radio-pharmacy Nanotechnology Neutron radiography New materials Metrology
The beginning 1956-1957 – training of group Bulgarian scientists and engineers in operation of IRT in Kurchatov Institute , Moskow: Simeon Ruskov, Vasil Hristov, Nikolay Buchvarov, Anton Markov, Ilija Mishev, Krikor Sakalijan and Dimitar Vatev.
Before the Reactor construction, 1956 The Reactor under construction
IRT-2000 Research Reactor Russian and Bulgarian specialists taking part in the IRT-2000 start-up IRT-2000 and related laboratories constituted a national centеr for scientific and applied research, as well as for education and training of specialists in the field of nuclear science and technology.
First stage of the construction and commissioning of the Kozloduy NPP 1970 – 1975 г. – construction of 1 and 2 unit with pressurized water reactors type WWER-440, model V-230. 30.06.1974 – Start up of unit 1 22.08.1975 – Start up of unit 2 The official opening of KNPP was on 4-th of 13 September 1974
The State Enterprise Radioactive Waste started the construction of National Disposal Facility for Low- and Intermediate Level Radioactive Waste - 29.08.2017
Basic environmental observatory Мисия ИРТ -200 Peak Moussala-2928 m. ОБУЧЕНИЕ Ядрена енергия, енергетика, технологии и изследвания Дозиметрия, лъчезащита и лъчеинженерство Физика и биология Ядрена култура ПРИЛОЖЕНИЯ Неутронен активационен анализ Производство на радиоизотопи Радио - фармация Облъчване на материали Неутронна радиография Материалознание Метрология
Laboratory for technical development - Physics
Radio ioactive tr transborder tr transfer: Fukushima 134Cs 0.06 131I 0.05 mBq/m3 0.04 0.4 0.03 0.02 mBq/m3 0.3 0.01 0.2 0 8h 23.03 8h 24.03 8h 25.03 8h 26.03 9h 27.03 9h 28.03 8h 29.03 8h 30.03 8h 31.03 8h 01.04 8h 02.04 8h 03.04 8h 04.04 8h 05.04 8h 06.04 8h 07.04 0.1 0 20h 24.03 21h 27.03 20h 30.03 20h 02.04 20h 05.04 8h 23.03 8h 26.03 8h 29.03 8h 01.04 8h 04.04 8h 07.04 time, date, month time, date, month 137Cs 0.07 0.06 mBq/m3 0.05 0.04 0.03 0.02 0.01 0 8h 23.03 8h 24.03 8h 25.03 8h 26.03 9h 27.03 9h 28.03 8h 29.03 8h 30.03 8h 31.03 8h 01.04 8h 02.04 8h 03.04 8h 04.04 8h 05.04 8h 06.04 8h 07.04 time, date, month
IN INRNE and Str tress-tests of th the NPP “Kozloduy” “Extreme external climate conditions”
Optimization of nuclear fuel behavior for 19 WWER-1000
Expert activ ivity Scientific Support for Nuclear Energy, Research and expertise for Nuclear Safety of NPP, BNRA, NPP "Kozloduy“ EAD, Ministry of energy, National electric company EAD, State Enterprise Radioactive Waste, and others.
The Cyclotron Laboratory at t IN INRNE-BAS
TR-24, ACSI(EBCO), Vancouver, Canada
TR-24, ACSI(EBCO), Vancouver, Canada • Accelerates H- ions • Extraction by stripping foils • Beam Energy: 15 – 24 MeV • Beam Current: 400 µA • Upgradeable to 1 mA • Dual Beam Extraction • External CUSP ion source • Turbomolecular and cryo vacuum pumps • Vacuum:5.10-7 – 10-6 Torr PET: 11C, 13N, 15O, 18F, 124I, 64Cu, 68Ge SPECT: 123I, 111In, 67Ga, 57Co, 99mTc
Beamlines, targets and target stations for PET&SPECT radioisotopes production x 1 x 3 x 2
The TR Family of Cyclotrons TR-30, 15-30 MeV, H-(D-) TR-24, 15-24 MeV, H- TR-19, 14-19 MeV, H-(D-) ● TR-30 was designed at TRIUMF , Canada at the end of the 80's and has been manufactured since then by ACSI(EBCO). ● Over 90% of all commercially supplied SPECT radioisotopes in North America, like 201Tl, 123I, 67Ga and 111In, are PRODUCED on TR-30 cyclotrons. ● Since 1996 all 30 MeV cyclotrons for commercial production of SPECT radioisotopes installed in North America are made by ACSI(EBCO). ● TR-30 cyclotrons have been operated 24/7 for 20+ years. ● In 2014 TRIUMF purchased a TR-24 cyclotron for its research program in radiopharmacy.
Radiochemical Laboratories fo for Production of PET Radiopharmaceuticals Equipment: Synthesis modules Hot Cells Laminar Flowbox
The Cyclotron Labora ratory at IN INRNE-BAS The aim is to establish a center for: Applied Research Training and Education in: R&D in Radiopharmacy Nuclear Energy; Production of Radiochemistry; Radiopharmaceuticals Radiopharmacy; Nuclear Physics; Fundamental Science – Radiation Protection. Chemistry, Biology, Physics
Current use of medical radioisotopes №1: 99 Mo/ 99m Tc Purpose №2: 18 F Therapy Theranostics 5% Diagnostics 44 Sc / 47 Sc Beta-emitters 95 % 64 Cu / 67 Cu 186,188 Re, 90 Y, 186/188 Re 86 Y / 90 Y 177 Lu, 131 I, 165 Dy 124 I / 123/131 I SPECT 166 Ho, 105 Rh, 111 Ag 67/68 Ga / 111 In 99m Tc, 111 In, 123 I, Alpha-emitters 99m Tc / 186/188 Re 201 Tl, 67 Ga PET 212 Bi, 213 Bi, 211 At 68 Ga / 67 Ga in-vitro 18 F, 11 C, 13 N 255 Fm, 225 Ac, 223 Ra 3 H, 14 C 15 O, 68 Ga, 64 Cu Brachytherapy 86 Y, 89 Zr, 124 I 32 P, 125 I 192 Ir, 182 Ta, 137 Cs 103 Pd, 125 I, 60 Co Theranostics = Therapy + Diagnostics
Cyclotron Vault Layout 30 A tender procedure for a project of the building is going to finish yesterday, 11.09.2018
⁶⁸ Ga 31p 37n Probability Mode Decay Energy Daughter 100.% β+ 1898.9keV ⁶⁸ Zn Yield Nuclide 100.% ⁶⁸ Zn Atomic Weight 67.927980084 Abundance None Mass Excess -67.08612MeV Binding Energy 8.70122MeV
⁶⁸ Ga as a radiopharmaceutical ⁶⁸ Ga in clinical trials proves itself to be a good contender for replacement of the currently used radionuclide pharmaceuticals (111In) and gives a great opportunity for optimization of treatments and imaging methods. Its shorter half-life of 68 minutes allows for faster clearance from the organism and it makes it possible to use on the same patient with a shorter waiting period in between application.
Fig. 1 A middle-aged patient has an 111 In-DTPA-octreotide SPECT/CT scan demonstrating a focus of uptake in a 1 cm right lower quadrant mesenteric lymph node (arrow, A and C). There is trace uptake in a normal sized (5 mm) peri-pancreatic lymph node (B) that prospectively was read as normal. Fig.2 68 Ga-DOTATATE PET/CT scan performed prior to surgery revealed the already known right lower quadrant lymph node (D and F) as well as clear-cut intense uptake in the peri-pancreatic lymph node (E) that was read earlier as normal. The surgical plan was changed to extent the field to include resection confirmed metastatic disease.
INRNE and National Scientific Road Map National cyclotron center EURATOM – INRNE CTA-MAGIC ACTRIS CERN JINR
Pro rojects 11 - EURATOM 8 with JINR, Dubna 6 - JRC 5 - “ Res. infrastructures ” 1 - “ Environment ” 1 - MCA IRSES 1 - ERA NET 3 – COST And more
Recommend
More recommend
