Incremental shuttle walking test predicts survival in non-group 1 - PowerPoint PPT Presentation

Incremental shuttle walking test predicts survival in non-group 1 pulmonary hypertension without a ceiling effect C. Billings 1 , R. Lewis 1 , J. Hurdman 1 , I. Armstrong 1 , I. Smith 1 , M. Austin 1 , C. Elliot 1 , A. Charalampopoulos 1 , I. Sabroe 1 , A. Lawrie 2 , R. Thompson 2 , R. Condliffe 1 , D. Kiely 1 1 Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital - Sheffield (United Kingdom), 2 Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School - Sheffield (United Kingdom) Background • 6-MWT is a widely used sub-maximal walking test in pulmonary hypertension • ISWT externally paced incremental exercise test 1 • Previously shown that ISWT distance predicts survival in Group 1 PAH 2 Methods • Data from ASPIRE registry • ISWT within 3/12 of RHC • Treatment naïve and have non-group 1 pulmonary hypertension 1. Singh S et al, Thorax 2008 2. Billings CG et al, J Heart and Lung Transplant 2017

Incremental shuttle walking test predicts survival in non-group 1 pulmonary hypertension without a ceiling effect Results n 1 year mortality % Band 5 Band 4 ISWD (m) 0-120 248 20.2 Band 3 130-420 203 9.4 Band 2 >420 28 0 Band 1 ISWD (%pred) 0-20 248 21.1 Band 1 ISWD m: 0-30; Band 2: 40-120; Band 3: 130-250; >20-60 212 8.0 Band 4: 260-420; Band 5: 430 - 1020 >60 21 0 Billings CG, Lewis R et al,

Incremental shuttle walking test predicts survival in non-group 1 pulmonary hypertension without a ceiling effect Conclusion • ISWD and ISWD%pred correlates with symptoms and haemodynamics • ISWD predicts survival in non-group 1 PH • Can be used to risk stratify patients • Provides an alternative field walking test to 6MWT Robert Lewis was fully funded to attend the ERS by Pulmonary Vascular Research Institute