Inauguration the 4 th July 2019 - Signature on April 3 rd , 2017 of - PowerPoint PPT Presentation

Scientific Platform Pasteur USP InovaUSP Av. Prof. Lucio Martins Rodrigues 370 Bloco A, Cidade Universitaria CEP 05508-020 São Paulo Brazil Executive Coordinators : Luis Carlos S. Ferreira – USP Paola Minoprio – Institut Pasteur Inauguration the 4 th July 2019

- Signature on April 3 rd , 2017 of the creation of an Administrative Office of the Institut Pasteur, USP, São Paulo - Signature on July 1 st , 2017, of the USP/PASTEUR/FUSP agreement on the Scientific Platform Pasteur-USP (SPPU) ,the 1 st site of the future IPB, in the state of São Paulo (1700 m 2 )

Global Biodiversity hot spot Climate changes Microbiota • The 6 Brazilian ecosystems, climate and humidity can create relevant conditions for the proliferation of vectors Impact on : migration of vectors, microbial resistance emerging or reemerging diseases transmission anthropological issues, land use, nutrition, water quality • Capitalizing ressources offered in the country and in the South American region contributing to the better appreciation of the genetic background, environment and microbiome in shaping host immune responses - Agreement on August 31 st , 2016 about the Scientific Strategy, « Microbes, Environment and Health »

Most specific Initiatives • Laboratory infrastructures, following strict biosafety and quality issues • Joint research programs & laboratories and mixed international units • Trilateral and multilateral innovative courses • Promotion of innovation leading to discovery of new products and processes in partnership with public and private industrial sectors

« Resident scientists » Laboratory Title Principal Investigators Neurological Disease Modeling Patricia Beltrão-Braga Computational Systems Biology Helder Nakaya Paolo Zanotto & Systems Virology Edison L. Durigon Tropical Epidemiology (office) Eduardo Massad Trypanosomatids Infectious Paola Minoprio Processes Biosafety management Pedro Teixeira Jean Pierre Schatzmann 1 st G4 Peron Technician To be recruited (Washing/Kitchen/Medium) Technician (Animal House) To be recruited

Management of Biosecurity Establish standardization of procedures in terms of hygiene and safety of laboratories, To translate and adapt French rules to the Brazilian reality Prepare a series of courses that are mandatory for professionals before the platform installations. Pedro Teixeira (FIOCRUZ)

System Virology Applied virology focusing on reverse genetics and viral erotics with viral isolates from relevant outbreaks and with emphasis on emerging viruses. Studies in 2-D and 3-D systems and in vivo studies in murine isolates of YFV, Dengue, CHIKV, USUV, WNV and ZIKV and other pathogenic viruses detected with an emphasis on neuroinvasiveness, neuropathogenesis and blood-brain barrier permeability. Discovery of new viruses, biobanks, immunotherapeutic and diagnostic strategies Edison Durigon & Paolo Zanotto

Tropical Epidemiology Eduardo Massad Development of Mathematical, Computational and Statistical Models of Transmission Dynamics and Control of Tropical Pathogens

Neurological Disease Modeling 3D 2D Brain Organoid Patricia C. B. Beltrao Braga

Neuroimmunology of Arboviruses (G4) Study of neuroimmune mechanisms involved in nervous system damage caused by arbovirus’ infections in experimental models Jean Pierre Schatzmann Peron

Trypanosomatids Infectious Processes • 2D and 3D image strategies applied to experimental models • New therapeutic and diagnostic strategies Paola Minoprio � � B�

Computational Systems Biology Helder Nakaya.

The ability to innovate is critical for economic, social and environmental development Attract resources from private initiative and the international research funding circuit 13 | Minoprio | 28/06/2019