I nstitut Pasteur: health research and Japan Science and Technology - PDF document

I nstitut Pasteur: health research and Japan Science and Technology Forum intervention w orld-w ide 5 October 2007 Paul Brey 1

I nstitut Pasteur ’s creation 1 8 8 7 : Established by international fund raising ( Russia, Brazil, Japan, France) follow ing L. Pasteur’s Rabies vaccine success « Our institute w ill be both a health center for treating rabies, a research center for infectious diseases and a learning center » Louis Pasteur 2

I nstitut Pasteur and Japan : a long lasting relationship • I n 1 8 8 6 , w hen Pasteur raised funds to create the I nstitute, the personnel from a com pany from Yokoham a participated • The first Japanese student in the m icrobiology course w as Dr Yabe, in 1 8 9 7 Silk worm • I n 1 9 2 2 , for centennial of Pasteur’s birth, Japan donated 2 m agnificent vases. They now are in the crypt, w here Pasteur is buried. • I n 2 0 0 5 , the creation of the Association Pasteur Japon To help prom ote I nstitut Pasteur in Japan 3

I nstitut Pasteur The founding vision of I nstitut Pasteur is to im prove hum an health and w elfare through scientific discovery. Challenge Today : is to translate this vision into tw enty first century science and technology within a complex global framework confronted with environmental change, emerging infectious disease and non-infectious diseases. Aim : is to is to continue to im prove hum an health and w elfare through scientific discovery by having a better understanding of the underlying mechanisms of environmental change on pathogens and their reservoirs as related to their mode of transmission, persistence and adaptation to humans. To integrate the most cutting edge technologies along with traditional natural history studies on pathogens, as well as to better understand the mechanisms leading to cancer and neurological diseases. 4

I nstitut Pasteur in 2 0 0 7 • Research Study of infectious diseases, immune, genetic and neurological diseases for both prevention and cure. • Public health Reference Centers, WHO Collaborating Centers, Outpatient Medical center • Education and training 1,100 students and trainees from 63 Countries • International Network 30 Institutes on 5 continents 5

I nstitut Pasteur in 2 0 0 7 A PRI VATE FOUNDATI ON Public Funding Donations & Legacies 32% 33 % 35 % Business Development : fees, royalties, expert appraisals Annual budget (2006): 217 M € 6

Biom edical Research and Public Health 7

I nstitut Pasteur: Research 1 3 0 laboratories 2 0 cutting-edge core facilities Genom ics and Proteom ics, Microarrays, Molecular Cryo-m icroscopy, TEM, Dynam ic I m aging, etc. More than half of research is devoted to infectious diseases I ncreasing efforts on neglected and em erging diseases. New labs and projects: Viruses ( Avian Flu, Chik, …) , Malaria, Leishm ania, Trypanosom a, Buruli ulcer

I nstitut Pasteur: biom edical research Global Health and infectious diseases Viral diseases AI DS, Flu, dengue, rabies, hepatitis, poliom yelitis, yellow fever, SARS, haem orrhagic fevers,... Bacterial diseases Tuberculosis, enteric diseases, plague, w hooping cough, m eningitis, anthrax, resistance to antibiotics,... Parasitic diseases Malaria, leishm aniasis, am ibiasis, Chagas disease, sleeping sickness... Fungal diseases Cryptococcosis, candidiasis, aspergillosis,... 9

I nstitut Pasteur: biom edical research � Cancers, genetic diseases � Neuroscience and Neurodegenerative disease: autism, deafness, Alzheimer’s � Development of heart muscle � Genomics and post- genomics � etc... 10

I nstitut Pasteur Technology transfer � Vaccines � Diagnostic tests � Drugs � Environment � Incubator for start- up companies - several successful IPOs

Public Health Services 12

National Reference and W HO Collaborating Centers 20 Reference Centers and 8 WHO Collaborating Centers monitor epidemics; provide technical advice at the national and international level. For example : WHO reference center for Influenza and Rabies… CIBU : emergency intervention unit for unknown pathogens on call 24 hours, 7 days/week, 365 days/year For example : SARS outbreak in China and Vietnam 13

The Medical Center � a Center for international vaccination and travel m edicine � an outpatient clinic, including tropical m edicine, derm atology, parasitology, m ycology and allergic reactions 14

collaborations I nternational 15

The I nternational Collaborations • To strengthen the scientific relations w ith the other international organizations • To develop projects in partnership w ith other foundations or international actors: W orld Health Organization ( W HO) GAVI ( Global Alliance for Vaccines and I m m unization) Bill & Melinda Gates Foundation DNDi ( Drugs for Neglected Diseases initiative) Bellagio Forum W ellcom e Trust - Oxford Tropical Medicine Unit U.S. Departm ent of Health and Hum an Services • To prom ote the developm ent of regional poles : Asia, Europe, Africa, Middle-East, Latin Am erica 16

Scientific collaborations Japan- I nstitut Pasteur in 2 0 0 7 1 . Collaborations w ith RI KEN Center for Developmental Biology , Kobe • Research Center for Allergy & Immunology (RCAI) , • Yokoham a • RIKEN Tsukuba • Research Institute for Microbial diseases (BIKEN), Osaka • Brain Science Institute (BSI) , W ako 2 . Osaka University 3 . Tokyo University ( I MSUT) 17

I nstitut Pasteur I nternational Netw ork 18

Origin of the I nternational I nstitut Pasteur Netw ork Three years after the establishment of Institut Pasteur in Paris, Louis Pasteur decided to establish Institut Pasteur outside of metropolitan France sending his most talented young scientists to vaccinate populations against rabies and smallpox and to study infectious diseases “The future belongs to those who help suffering humanity” Louis Pasteur 19

Le Réseau I nternational des I nstituts Pasteur In 1891, Albert Calmette founded the first Institut Pasteur outside of metropolitan France in Saigon Today the network includes 30 institutes spanning five continents. 20

Institut Pasteur Laos 2009 The International network of 30 Institutes Pasteur Institutes 21

I nstitut Pasteur I nternational Netw ork Missions • Public Health Research • • Teaching & Training • Services Vaccine Production • QuickTime™ and a • Technology transfer TIFF (Uncompressed) decompressor are needed to see this picture. � To improve research capacity � To improve the public health in the countries where these institutes are located 22

Health and Sustainable developm ent A few exam ples of activities and program s addressing global health challenges • Avian flu diagnosis and surveillance ( Cam bodia, Laos, Vietnam and China) • Developm ent of rapid diagnosis “dip-sticks” for plague, cholera, m eningitis ( I Ps in Africa) • Distribution of bed nets and m alaria surveillance • Rem ote Sensing Surveillance studies to help predict outbreaks of Vector borne and Avian borne diseases • Food safety and Environm ental hygiene 23

I nstitut Pasteur Netw ork in ASI A

• Hong-Kong • Cambodia • Shanghai • Vietnam • Korea • Laos I nstituts Pasteur in Asia 25

I nstitut Pasteur of Korea Created in 2003 Staff : up to 250 people RESEARCH : • Cancer, hepatitis, inflammation • Therapeutics targets (malaria, AI) • Enabling technology development QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Synergies between: • IP Paris: competence in Biological research & Therapy development and • IP Korea: competence in Information technology, Robotics, Nanotechnology, Enabling Technology/ Research & Development 26

I nstitut Pasteur de Shanghai / Chinese Academ y of Sciences Created in 2004 Staff : up to 160 people RESEARCH : • Virology : Emerging viral diseases : SARS, bird flu, HIV/ AIDS, hepatitis • encephalitis, hemorrhagic fevers • Immunology • Epidemiology 27

Hong-Kong University - Pasteur Research Centre Created in 2000 Staff : 20 people RESEARCH : • Emerging viral diseases: SARS, bird flu • Hepatitis C & HIV QuickTime™ and a QuickTime™ and a TIFF (Uncompressed) decompressor TIFF (Uncompressed) decompressor are needed to see this picture. are needed to see this picture. 28

I nstituts Pasteur in Vietnam IP Saigon 1891 (A. Calmette) IP Nha Trang 1895 (A. Yersin) IP Hanoi 1926 (N. Bernard) -> NIHE Staff : > 500 people Vietnamese Ministry of Health RESEARCH : • Prevention and treatment of infectious diseases • Emerging viral diseases: SARS, Avian Influenza (H5N1), Encephalitis • Bacterial diseases • Dengue Fever/ Medical Entomology • Hepatitis C HIV/ AIDS • Vaccine production 29

I nstitut Pasteur of Cam bodia Created in 1927 Staff : 100 people RESEARCH : • Prevention and treatment of infectious diseases • Emerging viral diseases: SARS, bird flu • HIV/ AIDS • Dengue • Mycobacterium spp. Infections • Malaria 30