HOW OUR BODIES CAN HEAL ITSELF W W W . R E G E N C E L L U L A R . N - PowerPoint PPT Presentation

OPTION C… HOW OUR BODIES CAN HEAL ITSELF W W W . R E G E N C E L L U L A R . N Z

PLAYED SPORT?? W W W . R E G E N C E L L U L A R . N Z

BEFORE W W W . R E G E N C E L L U L A R . N Z

ARTICULAR CARTILAGE W W W . R E G E N C E L L U L A R . N Z

WHAT’S OSTEOARTHRITIS (OA) ✓ Disease of the whole joint ✓ Osteoarthritis substantially reduces the amount of healthy years of life lived ✓ Fourth leading cause of disability worldwide ✓ No cure ✓ By 2040.. one million people in NZ will have arthritis W W W . R E G E N C E L L U L A R . N Z

AFTER 9 MONTHS POST 58 YEAR OLD MALE RIGHT KNEE TREATMENT W W W . R E G E N C E L L U L A R . N Z

PURE EXPANDED STEM CELL THERAPY ✓ Only company in NZ (2 in Australia) using the Pure Expanded Stem Cell protocol (PESC) which allows cartilage to grow PURE EXPANDED ✓ Non-invasive treatment. Can eliminate or delay surgery STEM CELL TREATMENT ✓ We grow a patients own cells in our lab to massive numbers for injection into affected area FOR OSTEO & SPORTS INJURIES ✓ We specialise in treatment of osteoarthritis & sports injuries ✓ Our treatment based on successful medical trials ✓ Backed by the Medical Council W W W . R E G E N C E L L U L A R . N Z

WHERE DO THEY COME FROM? ✓ Our body fat stores mesenchymal Stem Cells – MSCs ✓ A mesenchymal stem cell is a primitive cell which can differentiate depending on placement ✓ We are interested in MSCs because of their ability to regrow cartilage

WHAT CAN STEM CELLS DO?

HOW THE TREATMENT WORKS

ME Oct 30 2019 W W W . R E G E N C E L L U L A R . N Z

CURRENT MEDICAL OPTIONS MEDICATE OPERATE

Kellgren-Lawerence Grading Scale REGEN CELLULAR GRADE 1 GRADE 2 GRADE 3 GRADE 4 CLASSIFICATION NORMAL DOUBTFUL MILD MODERATE SEVERE W W W . R E G E N C E L L U L A R . N Z

AVERAGE AGE OF DIAGNOSIS OF KNEE OSTEOARTHRITIS 1990s VS 2010Ss STATISTICS OF KNEE OSTEOARTHRITIS W W W . R E G E N C E L L U L A R . N Z

$993m $7.9b $3.3b COST OF Health sector costs ARTHRITIS Other financial costs IN NZ 2018 Loss of wellbeing (osteo major component ) $321m dominated by osteoarthritic knee and hip surgeries. $34.9m cost of GP visits in 2018 due to arthritis $69.5m pharmaceutical bill $210m medical specialists/allied health services (21% of total health cost). W W W . R E G E N C E L L U L A R . N Z Source: Deloitte Access Economics analysis

PATIENTS ARE EXTREMELY UNSATISFIED: HIGH UNMET MEDICAL NEED Today’s treatment paradigm is trapping patients in a vicious cycle of OA knee pain Knee OA patients are highly 19% satisfied with their current treatment THE VICIOUS Not Ready for total knee CYCLE OF 91% replacement OA KNEE PAIN Will try almost anything prior 59% to surgery

REGEN IN THE MEDIA

FACING YOUR CRITICS W W W . R E G E N C E L L U L A R . N Z

CASE 1 KNEE CARTILAGE BEFORE TREATMENT AFTER PESC TREATMENT REGEN MRI RESULTS W W W . R E G E N C E L L U L A R . N Z

MELBOURNE May 28, 2019 Results of the world's largest published trial on the benefits of stem-cell therapy for osteoarthritis. EVIDENCE BASED MEDICINE Stem cell therapy improves the quality of life of those affected by more than to 290% Study shows that stem cells can stop the progression of osteoarthritis and regrow cartilage. Regenerative Medicine Journal W W W . R E G E N C E L L U L A R . N Z

Regenerative medicine by the use of cell and gene therapy and tissue engineering has emerged as one of the most exciting areas of biotechnology, raising hopes for researchers, clinicians, and patients. Having as its main purpose the regeneration of injured tissue and not its replacement with an external device, advances in this field may avoid treatments based on grafts and artificial prostheses. Regenerative medicine offers the possibility of personalization and to treat multi-factorial diseases such as osteoarthritis. October 23, 2019

First clinical trial between academic institution and stem cell company in Australasia REGEN CLINICAL TRIAL 2020 W W W . R E G E N C E L L U L A R . N Z

“HOCUS POCUS” “WITCHCRAFT” W W W . R E G E N C E L L U L A R . N Z

Response rate for PESC in cartilage and tendon repair KNEES REGEN RESULTS Over 90% SHOULDERS 80% HIPS 80% HANDS, ANKLES, WRISTS 70% Patient mean age: 48-82 years W W W . R E G E N C E L L U L A R . N Z

BUT STEM CELLS ARE EXPENSIVE RIGHT? REPLACEMENT PESC SURGERY TREATMENT HIP $25-30,000 (ONE) HIP $12,500 (ONE) $15,000 (TWO) KNEE $12,500 (ONE) $15,000 (TWO) KNEE $22-26,000 (ONE)

OWEN FRANKS THIS IS OWEN FRANKS SO IS THIS

JAN 2018 OCT 2018 JASON HIPS W W W . R E G E N C E L L U L A R . N Z

REGEN CELLULAR W W W . R E G E N C E L L U L A R . N Z

TELL GOOD PUSH STORIES KEEP IN THE MAKE FACES OF OUR OUTCOMES BIGGEST RELATABLE CRITICS W W W . R E G E N C E L L U L A R . N Z

Martine Rothblatt ─ Too 100 business minds ─ Highest paid US female CEO ─ Futurist

“Persistence is omnipotence” Martine Rothblatt CEO United Therapeutics W W W . R E G E N C E L L U L A R . N Z

FUTURE Healthcare Revolutions Report By 2040 ✓ Personalised medicine ✓ Stem cell medicine ✓ Nano-scale medicine ✓ Gene therapy and editing ✓ Digital health Ray Hammon Futurologist

HOPE 92 YEAR OLD PATIENT W W W . R E G E N C E L L U L A R . N Z

HEAL EMPOWER QUESTION WITHOUT PATIENT AUTHORITY HARM CHOICE