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Biofuels R&D a global community Steen Skjold Jorgensen, Vice president , R&D Novozymes North America NOVOZYMES INTEGRATES ALL THE COMPETENCES INVOLVED IN PROVIDING COST EFFECTIVE BIOLOGICAL SOLUTIONS Microbial Diversity


  1. Biofuels R&D – a global community Steen Skjold Jorgensen, Vice president , R&D Novozymes North America

  2. NOVOZYMES INTEGRATES ALL THE COMPETENCES INVOLVED IN PROVIDING COST EFFECTIVE BIOLOGICAL SOLUTIONS Microbial Diversity Artificial Gene Diversity Protein Evolution High Chemistry throughput Assay screening technologies Large Scale Pathway Fermentation, Bio-Informatics: Engineering Product Recovery, HTS sequencing & Formulation gene identification Expression Profiling; Protein Engineering: DNA Microarrays Structure / Function relationships Gene Expression (rDNA technology) Process Development 2

  3. 3 Our commitment to the Bioenergy field begins with our global R&D efforts • 1000 R&R people WW • 14 % of turnover ploughed back to R&D • Groundbreaking technology for grain based ethanol • Large global effort in cellulosic ethanol (2G) – around 150 in R&D – the largest single project ever. • More than 300 patents granted and more than 200 patent families submitted for biofuels to date – and growing • Also active in Biodiesel as well as Biogas developmental activities. More than 150 employees dedicated to 2G biofuels

  4. TYPICAL 1. GEN. FUEL ETHANOL PROCESS 105 C 85 C 85 C 31 C 33 C 85 C 33 C 80 C 4

  5. BPX (RAW STARCH BASED) FUEL ETHANOL PROCESS 31 C 33 C 33 C 33 C 80 C 5

  6. Roles of GA and AA in BPX process AA 100 90 80 70 60 relative enzyme 50 dose 40 30 20 10 0 BPX initial 1st Gen 2nd Gen 3rd Gen conv 6

  7. 7 Enzyme cost in use improvements Protein need Novozymes Application launched Cellic CTEC 2 in 2010 as a result of 10 Discovery years miltidisciplinary Production research Time & effort

  8. 8 Applied Discovery Reduce total process costs – focus on enzyme costs via holistic innovation Collection Recovery & Storage Hydrolysis pre-treatment fermentation • Highly interrelated technologies • Novozymes R&D tools and experience utilizing enzyme technology and application know-how to also provide ideas in p and f • Partnership is key

  9. 9 Deployment in collaboration with partners Inbicon  Lignol Greenfield   Nedalco  Poet  M&G  ADM  Ceres  Fiberight  COFCO & Sinopec  ICM  PRAJ  Petrobras  CTC  Dedini  • Novozymes key global cellulosic ethanol partners

  10. CELLULOSIC ETHANOL TECHNOLOGY IS REACHING COMMERCIALIZATION • Production costs for cellulosic ethanol are becoming competitive with gasoline and starch/sugar based ethanol • Capital costs must be balanced with operational expenses Novozymes Cellic CTec2 delivers on our 2010 promise by reducing the enzyme dose significantly to a level where cellulosic ethanol can be made economically 10

  11. 11 NZNA R&D: Competency center within Bioenergy processes – Tour our wetlab!

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