Gene Regulation 30 Years TRANSFAC Gttingen, March 07-09, 2018 - PowerPoint PPT Presentation

Bioinformatics of Gene Regulation 30 Years TRANSFAC Göttingen, March 07-09, 2018 Georg August University, Göttingen, Germany

Wingender E. Compilation of transcription regulating proteins. Nucleic Acids Res. 1988 Mar 25;16(5):1879-902. PMID: 3282223

Transcription TF Binding Site factor (TF) Matrix

Wingender, E., Heinemeyer, T. and Lincoln, D., Regulatory DNA sequences: predictability of their function. Genome Analysis - From Sequence to Function; BioTechForum- Advances in Molecular Genetics (J. Collins, A.J. Driesel, eds.) 4, 95-108 (1991)

Wingender, E., Heinemeyer, T. and Lincoln, D., Regulatory DNA sequences: predictability of their function. Genome Analysis - From Sequence to Function; BioTechForum- Advances in Molecular Genetics (J. Collins, A.J. Driesel, eds.) 4, 95-108 (1991)

TFClass TRANSFAC CLASS TRANSFAC MATRIX Factor Site classes models Factors Sites TRANSFAC FACTOR TRANSFAC SITE TRANSFAC FRAGMENT Wingender, E., Kel, A., Krull, M., Transcription factor databases. Encyclopedia of Bioinformatics and Computational Biology (M. Cannataro et al., eds.), Chapter 20216 (2018)

Wingender, E., Heinemeyer, T. and Lincoln, D., Regulatory DNA sequences: predictability of their function. Genome Analysis - From Sequence to Function; BioTechForum- Advances in Molecular Genetics (J. Collins, A.J. Driesel, eds.) 4, 95-108 (1991)

The transcription core network A signaling signaling signaling TF1 TF2 TF3 Gene 1 Gene 2 Gene 3 B C Gene 3 Gene 1 gene expression Gene 1 TF1 trans -regulation Gene 2 Gene 2

C. E. Shannon, The Bell System Technical Journal, 27:379 – 423, 623 – 656 (1948)