GA No: 688303 This project has received funding from the European - PowerPoint PPT Presentation

Laser and Ultrasound Co-Analyzer for thyroid nodules (LUCA) GA No: 688303 This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Motivation: Thyroid cancer is a major and growing health challenge. Chances of survival and full recovery heavily depend on an early and fast diagnosis and an effective treatment. CHARACTERISTICS - Low cost - Non-invasive device - Enhanced information people with thyroid nodules Better and more specific SCREENING results in thyroid nodule TECHNIQUES screening - Ultrasound SOCIAL IMPACT Better diagnosis - Fine Needle - Psychological complications Aspiration Biopsy - Work-day absences - Further healthcare Socio-economical FNAB’s /year impact: reduced number of thyroidectomies, Benign 750.000 false positives associated COST IMPACT vs or non-diagnosis in EU comorbidities and Malignant improved quality of life 448.5 Millions €/y of the patients €€€ could be saved! 3.000 € / surgery 150.000 unnecessary surgeries This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

The LUCA Vision Overview of the LUCA vision starting at the present clinical practice in thyroid screening and our current research followed by the proposed innovations during the LUCA period, for the short- and long-term following the end of LUCA. The goal of LUCA is to start at a technology readiness level (TRL) of TRL 5 and move to TRL 7. US : Ultrasound FNAB : Fine Needle Aspiration Biopsy TRS : Time Result Spectroscopy DCS : Diffuse correlation Spectroscopy This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Objectives »To develop a novel low-cost tool for the screening of thyroid nodules for malignant cancers »To develop an innovative probe that combines diffuse optics and clinical ultrasound for simultaneous multi ‐ parametric ultrasound imaging and optical measurement of tissue hemodynamics and composition of the thyroid nodules »To develop a multi-modal, point-of care device which integrates with the probe developed and a portable, low-cost ultrasound system »To establish the clinical usability of the LUCA device This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

The LUCA System → + Combination of Photonics and Ultrasound → → → Water Blood Flow Oxygenation Structure Local Non-invasive » Device → Illuminates the tissue with near-infrared light (non-invasive + local) »Combination of different diffuse optical techniques (TRS + DCS): → Light incident on tissue → Photon scattering and absorption depend on tissue structure and content »Algorithms for diffuse optics → The output of TRS and DCS is processed to give information on hemodynamics, metabolism and structure of the thyroid This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

TRS Time Resolved Spectroscopy Absorption spectrum of principal tissue components »TRS Method → Pico- second laser pulses illuminate the tissue → measurement of the absorption and scattering coefficient of the tissue by analyzing the deformation of the detected laser pulse → Use of 8 different wavelengths in the near infrared (~650- 1100nm) → the absorption spectrum gives information on the concentrations of different components »Output → Quantification of the concentrations of oxyhemoglobin (HbO 2 ), deoxyhemoglobin (Hb), lipid, collagen and water, i.e. structure & function This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

DCS Diffuse Correlation Spectroscopy Speckle pattern → P. Farzam, PhD Thesis, ICFO »DCS Method → Laser light goes into tissue → photons scattered by moving red blood cells generate a moving interference pattern (speckle pattern) → Measurement of the decay of the electric field autocorrelation function of a single speckle »Output → Quantification of micro-vascular blood flow, i.e. function This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Expected Impact »Improvement in the specificity of the thyroid screening process compared to the conventional ultrasound-based workflow » Earlier and faster diagnosis for an effective treatment and management and reduction of the number of surgeries » Potential application of the LUCA device in other types of cancer diagnosis, screening and therapy monitoring (in areas of the body accessible to both techniques ) »Reduction of socio-economic cost related to thyroid cancer 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 » Wide-market introduction of After LUCA the LUCA technology LUCA – IP generation and market monitoring Clinical research sales Within LUCA Clinical market Clinical trial sales This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

CONSORTIUM Optics, opto-electronics & Industrial: product developer End-users Researcher & Clinics Biophotonics Vermon S.A. The Institute of Photonic Sciences European Institute for Biomedical Imaging Research Politecnico di Milano Hemophotonics S.A. Consorci Institut University of Birmingham D’Investigacions Biomediques Echo Control Medical August Pi Sunyer This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. University of Birmingham www.luca-project.eu www.photonics21.org

Consortium‘s Expertise I CFO - Medical Optics group PI: Diffuse Correlation Spectroscopy Turgut Durduran, LUCA coordinator Knowledge & Technology Transfer POLIMI : Davide Contini, Time resolved Spectroscopy Dipartimento di Fisica Clinical Endocrinology and IDIBAPS : Ramon Gomis, Radiology Endocrinology Department Biomedical optical device development HEMO: Udo Weigel, Commercialization VERMON, An Nguyen-Dinh, Ultrasound Probes Technology & Research ECM, Sixte de Fraguier, R&D Ultrasound device software UoB, Hamid Dehghani, School of Physical modelling and data fusion Computer Science Biomedical imaging research EIBIR , Gabriel Krestin, Radiology project management This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Work Plan » Phase I (M1-M18): Development and construction of device components » Phase II (M12-M36): Testing of components and validation of device in laboratory settings » Phase III (M30-M48): Demonstration in real ‐ settings, feedback, upgrades and final tests This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Work Packages This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Work Packages: Objectives »WP1 Project Management  To achieve excellence in project management in technical and administrative terms »WP2 Development of components and sub-systems  To utilize innovative components for new sub ‐ systems and to develop an innovative, multi ‐ modal probe that combines diffuse optics and clinical ultrasound »WP3 Development of a demonstrator  To develop a low ‐ cost, portable, point ‐ of ‐ care, robust LUCA demonstrator that integrates with the probe developed in WP2 and with a portable, low ‐ cost ultrasound system »WP4 Ex vivo, phantom validation and standardization  To develop ex vivo phantoms and standards for validation and quality control This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Work Packages: Objectives »WP5 Validation in real-settings  To evaluate the clinical usability and validate the system in real-settings »WP6 Dissemination  To disseminate project results broadly as well as directly to stakeholders and end- users »WP7 Exploitation  To exploit the project results at all levels from know ‐ how and intellectual property generation to business plan development in order to commercialize the probe and the LUCA device This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org

Governance Structure This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 688303. www.luca-project.eu www.photonics21.org