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Forest Plots in Survival Subgroup Analyses Agenda CRO getting - PowerPoint PPT Presentation

Your statistical health consultancy CHM CRO TEMP WORK staying healthy getting healthy team health Forest Plots in Survival Subgroup Analyses Agenda CRO getting healthy Motivation ADTTE dummy data Macro for forest plots Summary


  1. Your statistical health consultancy CHM CRO TEMP WORK staying healthy getting healthy team health Forest Plots in Survival Subgroup Analyses

  2. Agenda CRO – getting healthy Motivation ADTTE dummy data Macro for forest plots Summary Forest Plots in Survival Subgroup Analyses 1/12

  3. Motivation CRO – getting healthy • Survival subgroup analysis, e.g. study from oncology Forest Plots in Survival Subgroup Analyses 2/12

  4. Motivation CRO – getting healthy • Survival subgroup analysis, e.g. study from oncology • Effect of study drug vs. placebo: Hazard ratio (HR) and confidence interval (CI) Forest Plots in Survival Subgroup Analyses 2/12

  5. Motivation CRO – getting healthy • Survival subgroup analysis, e.g. study from oncology • Effect of study drug vs. placebo: Hazard ratio (HR) and confidence interval (CI) • Comparing HRs and CIs among various subgroups Forest Plots in Survival Subgroup Analyses 2/12

  6. Motivation CRO – getting healthy • Survival subgroup analysis, e.g. study from oncology • Effect of study drug vs. placebo: Hazard ratio (HR) and confidence interval (CI) • Comparing HRs and CIs among various subgroups à Forest plot Forest Plots in Survival Subgroup Analyses 2/12

  7. Motivation CRO – getting healthy Simple example : 3/12 http://genometoolbox.blogspot.com/2014/06/easy-forest-plots-in-r.html

  8. Motivation CRO – getting healthy • Many endpoints in the study (Death, Progression free survival, ...) Forest Plots in Survival Subgroup Analyses 4/12

  9. Motivation CRO – getting healthy • Many endpoints in the study (Death, Progression free survival, ...) • Different confidence levels (e.g. 95% à 80%) Forest Plots in Survival Subgroup Analyses 4/12

  10. Motivation CRO – getting healthy • Many endpoints in the study (Death, Progression free survival, ...) • Different confidence levels (e.g. 95% à 80%) • Stratification ( à different model) Forest Plots in Survival Subgroup Analyses 4/12

  11. Motivation CRO – getting healthy • Many endpoints in the study (Death, Progression free survival, ...) • Different confidence levels (e.g. 95% à 80%) • Stratification ( à different model) • In our case: about 40 different forest plots Forest Plots in Survival Subgroup Analyses 4/12

  12. Motivation CRO – getting healthy • Many endpoints in the study (Death, Progression free survival, ...) • Different confidence levels (e.g. 95% à 80%) • Stratification ( à different model) • In our case: about 40 different forest plots à Macro needed! Forest Plots in Survival Subgroup Analyses 4/12

  13. Motivation CRO – getting healthy • Many endpoints in the study (Death, Progression free survival, ...) • Different confidence levels (e.g. 95% à 80%) • Stratification ( à different model) • In our case: about 40 different forest plots à Macro needed! • Macro: ADTTE data as input à Forest plot as output Forest Plots in Survival Subgroup Analyses 4/12

  14. ADTTE dummy data CRO – getting healthy Ob Subject Gender Age BMI at Treatment Parameter Censor Analysis Analysis s identifier group baseline code variable value value unit 1 123450000 Female >= 85 < 25 Study drug PFS 0 301 Days 1 2 123450000 Female >= 85 < 25 Study drug DEATH 1 315 Days 1 3 123450004 Male 65-74 25-30 Placebo PFS 1 1 Days 2 4 123450004 Male 65-74 25-30 Placebo DEATH 1 1 Days 2 5 123450011 Male < 65 > 30 Study drug PFS 0 51 Days 4 6 123450011 Male < 65 > 30 Study drug DEATH 0 94 Days 4 7 123450021 Female 75-84 . Placebo PFS 0 23 Days 0 8 123450021 Female 75-84 . Placebo DEATH 1 23 Days 5/12 0

  15. CRO – getting healthy Macro for forest plots %macro_forest_plot() Forest Plots in Survival Subgroup Analyses

  16. CRO – getting healthy Requirements & layout: • CI level & endpoint apparent in the title 7/12

  17. CRO – getting healthy Requirements & layout: • CI level & endpoint apparent in the title • HRs & CIs for each subgroup category + Subgroup size 7/12

  18. CRO – getting healthy Requirements & layout: • CI level & endpoint apparent in the title • HRs & CIs for each subgroup category + Subgroup size • Survival data: Events & censored patients 7/12

  19. CRO – getting healthy Requirements & layout: • CI level & endpoint apparent in the title • HRs & CIs for each subgroup category + Subgroup size • Survival data: Events & censored patients • Median survival times 7/12

  20. CRO – getting healthy Requirements & layout: • CI level & endpoint apparent in the title • HRs & CIs for each subgroup category + Subgroup size • Survival data: Events & censored patients • Median survival times • Footnotes 7/12

  21. CRO – getting healthy Requirements & layout: • CI level & endpoint apparent in the title • HRs & CIs for each subgroup category + Subgroup size • Survival data: Events & censored patients • Median survival times • Footnotes 7/12

  22. CRO – getting healthy Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each subgroup category + Subgroup size • Survival data: Events & censored patients • Median survival times • Footnotes 8/12

  23. CRO – getting healthy Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG + Subgroup size • Survival data: Events & censored patients • Median survival times • Footnotes 8/12

  24. CRO – getting healthy Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG + Subgroup size & • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes 8/12

  25. CRO – getting healthy Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG + Subgroup size & • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes Standard footnotes 8/12

  26. CRO – getting healthy Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG + Subgroup size & • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes Standard footnotes 8/12

  27. Main input: CRO – getting healthy ADTT E data Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG + Subgroup size & • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes Standard footnotes 8/12

  28. Main input: CRO – getting healthy ADTT E data Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG + Subgroup size & • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes Standard footnotes 8/12

  29. Main input: CRO – getting healthy ADTT E data Requirements: Options • CI level & endpoint apparent in the title • HRs & CIs for each PROC subgroup category PHREG Survival + Subgroup size & data • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes Standard footnotes 8/12

  30. Main input: CRO – getting healthy ADTT E data Requirements: Options • CI level & endpoint PROC apparent in the title SGPLOT • HRs & CIs for each PROC subgroup category PHREG Survival + Subgroup size & data • Survival data: Events PROC & censored patients LIFETEST • Median survival times • Footnotes Standard footnotes 8/12

  31. Main input: CRO – getting healthy ADTT E data Requirements: Options • CI level & endpoint PROC apparent in the title SGPLOT • HRs & CIs for each PROC subgroup category PHREG Survival + Subgroup size & Forest data • Survival data: Events PROC plot with & censored patients LIFETEST title & • Median survival times table • Footnotes Standard footnotes 6/9

  32. Main input: CRO – getting healthy ADTT E data Requirements: Options • CI level & endpoint PROC apparent in the title SGPLOT • HRs & CIs for each PROC subgroup category PHREG Survival + Subgroup size & Forest data • Survival data: Events PROC plot with & censored patients LIFETEST title, • Median survival times table & • Footnotes Standard footnotes footnotes 6/9

  33. CRO – getting healthy Macro call – example 1: %macro_forest_plot( endpoint = pfs , ci_level = 95 , sgrp_vlst = sex agegr01n , sgrp_lbls = Gender~Age Group , footnote1 = Up to five additional footnotes (footnote1- footnote5) possible. ); 9/12

  34. CRO – getting healthy Macro call – example 1: %macro_forest_plot( endpoint = pfs , ci_level = 95 , sgrp_vlst = sex agegr01n , sgrp_lbls = Gender~Age Group , footnote1 = Up to five additional footnotes (footnote1- footnote5) possible. ); 9/12

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