Figures from the 2015 Assisted Reproductive Technology National - PowerPoint PPT Presentation

Figures from the 2015 Assisted Reproductive Technology National Summary Report

Locations of ART Clinics in the United States and Puerto Rico, 2015 Number of ART clinics in the United States in 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 499 Number of ART clinics that submitted data in 2015 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 464 Total number of ART cycles started in 2015 at clinics reporting data. . . . . . . . . . . . . . . . . . . . . . . . . . . . 231,936 * Number of live-birth deliveries resulting from ART cycles started in 2015 . . . . . . . . . . . . . . . . . . . . . . . . 60,778 Number of infants born as a result of ART cycles started in 2015. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72,913 * Total includes 45,779 cycles with the intent to freeze all eggs or embryos. Live-birth deliveries and infants born are based on remaining 186,157 cycles with intent to transfer at least one egg or embryo. This includes 4,003 cycles with intent to fertilize previously frozen eggs and transfer resulting embryos. This does not include 1 cycle evaluating a new treatment procedure.

Types of ART Cycles—United States, * 2015 Frozen egg 1.7% New treatment (4,003 cycles) Fresh donor 3.2% procedure <0.1% (7,336 cycles) (1 cycle) Frozen donor embryo 6.0% (13,846 cycles) Fresh nondonor Egg/embryo 39.3% banking 19.7% (91,090 cycles) (45,779 cycles) Frozen nondonor embryo 30.1% (69,882 cycles) * Total does not equal 100% due to rounding.

ART Use by Age Group—United States, * 2015 Age: >44 5.1% Age: 43–44 6.4% Age: 41–42 Age: <35 10.0% 38.1% Age: 38–40 19.4% Age: 35–37 21.0% * Based on 231,936 cycles.

Types of ART Cycles by Age Group—United States, * 2015 97% 100 95% 90% (44) (45) 82% (38) 80 (29) 71% 65% (50) 60 (19) Percent (53) (53) (52) (50) 40 (46) 34% 29% (22) (10) 18% 20 (21) 10% (19) (11) 4% 5% (6) (12) (7) (4) 0 <35 † 43–44 † 35–37 38–40 41–42 >44 Age (years) Fresh nondonor Fresh donor Frozen nondonor Frozen donor * Percentages of ART cycles that used fresh or frozen embryos from nondonor or donor eggs are in parentheses. † Totals do not equal 100% due to rounding.

Percentages of ART Cycles That Resulted in Live Births, by Type of ART and Clinic Size—United States, 2015 60 50 46 44 44 42 42 41 40 38 38 40 37 37 34 Percent 30 26 26 24 23 20 10 0 <102 102–204 205–463 >463 Clinic Size (number of ART cycles performed in 2015) Fresh nondonor Frozen nondonor Fresh donor Frozen donor

Percentages of ART Cycles Using Fresh Embryos from Frozen Nondonor or Donor Eggs That Resulted in Cancellations, Pregnancies, Live Births, and Single-Infant Live Births, * 2015 60 50 47.2 38.6 40 Percent 30.2 29.3 30 22.7 18.8 20 10 7.3 6.0 0 Cancellations Pregnancies Live births Single-infant live births Nondonor Donor * Cycles using both nondonor and donor frozen eggs are excluded.

Outcomes of ART Cycles Using Fresh Nondonor Eggs or Embryos, by Stage, 2015 100,000 91,090 cycles 80,000 started 80,644 retrievals 60,000 Number 59,336 transfers 40,000 26,708 20,000 21,771 pregnancies live-birth deliveries 0

Reasons ART Cycles Using Fresh Nondonor Eggs or Embryos Were Canceled, *† 2015 Over response to Concurrent illness ovarian stimulation medication 0.9% 4.2% Patient withdrawal for other reasons 12.5% No or not enough egg production 82.3% * Based on 10,446 ART cycles. † Total does not equal 100% due to rounding.

Percentages of ART Cycles and Transfers Using Fresh Nondonor Eggs or Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births, 2015 50 45.0 40 36.7 29.3 28.3 30 Percent 23.9 18.5 20 10 0 Pregnancies Live births Single-infant live births Cycles Transfers

Outcomes of ART Cycles Using Fresh Nondonor Eggs or Embryos, 2015 Not able to determine number of fetuses 2.0% Ectopic pregnancy Clinical pregnancy 0.5% 29.3% Multiple- fetus pregnancy 6.9% Single-fetus pregnancy No pregnancy 20.4% 70.2%

Outcomes of Pregnancies That Resulted from ART Cycles Using Fresh Nondonor Eggs or Embryos, *† 2015 Induced abortion Unknown 0.7% 0.9% Miscarriage 16.3% Stillbirth 0.7% Multiple-infant Single-infant birth birth 63.0% 18.6% Total live births 81.6% * Maternal deaths prior to birth are not displayed due to small number of cycles. † Total does not equal 100% due to rounding.

Distribution of Multiple-Fetus Pregnancies and Multiple-Infant Live Births Among ART Cycles Using Fresh Nondonor Eggs or Embryos, 2015 Triplets or more 1.0% Not able to Triplets determine Twins Twins or more number of 22.1% 22.4% fetuses 0.6% 7.0% Single infants Single fetuses 77.2% 69.6% B. 21,771 live births * A. 26,708 pregnancies * Total does not equal 100% due to rounding.

Percentages of Preterm Infants or Infants with Low Birth Weight from ART Cycles Using Fresh NondonorEggs or Embryos, by Number of Infants Born, 2015 96.3 100 93.5 80 58.2 55.9 60 Percent 40 16.6 16.0 20 11.0 9.2 0 Single infants Single infants Twins Triplets or more from single-fetus from multiple-fetus pregnancies pregnancies Number of Infants Born Preterm infants Low birth weight infants

Age Distribution of Women Who Had ART Cycles Using Fresh NondonorEggs or Embryos, 2015 10 9 8 7 6 Percent 5 4 3 2 1 0 <24 24 26 28 30 32 34 36 38 40 42 44 46 48 >48 Age (years) Mean Median

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births, by Age of Woman, * 2015 60 50 40 Percent 30 20 10 0 <24 24 26 28 30 32 34 36 38 40 42 44 >44 Age (years) Pregnancies Live births Single-infant live births * For consistency, all percentages are based on cycles started.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Pregnancies, Live Births, and Single-Infant Live Births Among Women Aged 40 or Older, * 2015 30 20 20 Percent 15 14 12 11 10 10 8 8 7 6 6 3 3 3 3 2 1 1 0 40 41 42 43 44 > 44 Age (years) Pregnancies Live births Single-infant live births * For consistency, all percentages are based on cycles started.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Miscarriage, by Age of Woman, 2015 70 60 50 40 Percent 30 20 10 0 <24 24 26 28 30 32 34 36 38 40 42 44 >44 Age (years)

Outcomes of ART Cycles Using Fresh Nondonor Eggs or Embryos, by Stage and Age Group, 2015 100 93 89 85 80 78 76 80 71 68 62 60 54 Percent 49 41 38 40 33 32 26 23 17 20 14 8 7 3 3 1 0 <35 35–37 38–40 41–42 43–44 >44 Age (years) Retrieval Transfer Pregnancy Live birth

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos, by Type of Infertility Diagnosis, * 2015 40 34.8 30.8 30 Percent 17.7 20 14.3 13.9 13.9 12.8 11.0 8.8 10 5.3 0 Diagnosis * Total percentages are greater than 100% because more than one diagnosis can be reported for each cycle.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Type of Infertility Diagnosis, 2015 40 28.8 29.0 27.6 30 27.1 24.0 22.0 Percent 18.5 17.3 17.3 20 13.1 10 0 Diagnosis

Percentages of ART Cycles Using Fresh NondonorEggs or Embryos That Resulted in Live Births, by Age Group and Number of Previous Live Births, 2015 50 40 37 34 32 29 28 30 Percent 25 18 20 17 16 10 8 8 10 4 3 3 1 1 <1 0 <35 35–37 38–40 41–42 43–44 >44 Age (years) No previous live births 1 previous live birth 2 or more previous live births

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Age Group and History of Miscarriage, Among Women with No Previous Births, * 2015 50 40 32.6 31.8 30 Percent 25.5 24.0 20 16.5 16.2 8.1 7.9 10 3.0 2.9 0.9 0.9 0 <35 35–37 38–40 41–42 43–44 >44 Age (years) No previous pregnancies 1 or more previous miscarriages * Women reporting only previous ectopic pregnancies or pregnancies that ended in induced abortion are not included.

Percentages of ART Cycles Using Fresh Nondonor Eggs or Embryos That Resulted in Live Births, by Age Group and Number of Previous ART Cycles, Among Women with No Previous Live Births, 2015 50 40 34 29 28 30 Percent 26 23 23 21 19 20 16 15 14 11 10 9 10 6 5 3 3 3 2 1 1 1 1 0 <35 35–37 38–40 41–42 43–44 >44 Age (years) No previous cycles 1 previous cycle 2 previous cycles 3 or more previous cycles

Percentages of Retrievals Using Fresh Nondonor Eggs or Embryos That Used ICSI, * 2015 100 95.0 94.6 94.0 93.8 92.5 91.5 80.0 76.5 80 72.7 71.3 70.0 69.3 60 Percent 40 20 0 <35 35–37 38–40 41–42 43–44 >44 Age (years) ICSI, with male factor ICSI, no male factor * Cycles using GIFT are excluded.