Switch to Etravirine from PI-Based Regimen ETRA-SWITCH STUDY
Switch to Etravirine from PI-Based Regimen ETRA-SWITCH: Design Study Design: ETRA-SWITCH • Background : Open label, randomized phase 3b trial that enrolled patients with suppressed viral load while taking a ritonavir-boosted PI plus Switch Group 2NRTIs and examined the efficacy and safety of switching the ritonavir-boosted PI to etravirine Switch from PI to ETR (n = 22) • Inclusion Criteria (n = 43) - On PI >12 months - HIV RNA <50 copies/mL for >6 months - No NRTI or NNRTI resistance Maintain Group - No prior virologic failure with prior regimen Continue PI-based Regimen - Patients had dyslipidemia OR use of lipid (n = 21) lowering medication OR GI disturbance OR persistent dissatisfaction with current regimen • Treatment Arms - Switch PI in regimen to etravirine 400 mg/day - Continue current PI-based ART regimen Source: Echeverría P, et al. PLoS One. 2014;9:e84676.
Switch to Etravirine from PI-Based Regimen ETRA-SWITCH: Result Week 48: Virologic Response (ITT Analysis, Missing = Failure) Etravrine (Switch Group) PI (Maintain Group) 100 95 HIV RNA ≤ 50 copies/mL (%) 91 80 60 40 20 21/22 19/21 0 Source: Echeverría P, et al. PLoS One. 2014;9:e84676.
Switch to Etravirine from PI-Based Regimen ETRA-SWITCH: Result Week 48: Change in Plasma Lipids from Baseline Etravirine Group PI (Control) Group 25 Median change (mg/dL) 1.2 0.9 0 -0.1 -1.0 -6.1 -16.4 -25 -29.6 -50 -54.0 -75 Total Cholesterol HDL LDL Triglycerides Source: Echeverría P, et al. PLoS One. 2014;9:e84676.
Switch to Etravirine from PI-Based Regimen ETRA-SWITCH: Result Patient Satisfaction Scores Etravirine (Switch Group) PI (Maintain Group) 12 Patient Satisfaction Score 10 9.2 (Likert scale 0-10) 8.9 7.7 8 6.0 6 5.3 5.2 4 2 0 Baseline 24 Weeks 48 Weeks Study Week Source: Echeverría P, et al. PLoS One. 2014;9:e84676.
Switch to Etravirine from PI-Based Regimen ETRA-SWITCH: Conclusions Conclusion : “Switch from a PI -based regimen to a once-daily combination based on ETR maintained undetectable VL during 48 weeks in virologically suppressed HIV-infected patients while lipid profile and patient satisfaction improved significantly.” Source: Echeverría P, et al. PLoS One. 2014;9:e84676.
Acknowledgment The National HIV Curriculum is an AIDS Education and Training Center (AETC) Program resource funded by the United States Health Resources and Services Administration. The project is led by the University of Washington and the AETC National Coordinating Resource Center. The content in this slide set does not represent the official views of the U.S. Department of Health and Human Services, Health Resources & Services Administration.
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