effective antibiotics: Antibiotics revolutionized medicine US 1950s - PowerPoint PPT Presentation

Modern medicine is built on access to effective antibiotics: Antibiotics revolutionized medicine US 1950’s The introduction of penicillin increased the chance of survival of pneumonia patients from 25% to 80% Antimicrobial resistance: an alarming problem Antibiotic resistance threatens a return to the pre-antibiotic era In the EU, more than 25 000 patients die from multidrug resistant bacteria annually (EMA/ECDC report) Extra health-care costs and productivity losses of at least 1,5 billion EURO per year

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1. Mapping the AMR landscape funding and resources 2. Developing International Collaboration 3. Exploratory / Scoping workshops 4. Calls for Research Proposals 5. Alignment of Research Programs and AMR international policies 6. Virtual Research Institute (research infrastructures, research institutes and capacity building)

JPIAMR has funded approx. 52 M € of AMR research supporting 50 projects NETWORKS/WORKING GROUPS RESEARCH PROJECTS Interventions Interventions 9% 9% Environment Therapeutics Environment Therapeutics 9% 27% 9% 29% Transmission Diagnostics 14% 0% Surveillance 4% Diagnostics 14% Transmission Surveillance 49% 27% Call 1. Therapeutics Call 2. Therapeutics Call 3. Transmission Call 4. Networks/Working Groups Call 5. Interventions

1. JOINT RESEARCH OF PROPOSALS CALL (open) • New Targets, New Compounds, New Tools for New Antibiotics • Addressing WHO priority list bacteria 2. NETWORKS/WORKING GROUPS CALL ON SURVEILLANCE: • Surveillance knowledge gaps to be addressed by JPIAMR Networks 3. NETWORKS/WORKING GROUPS CALL ON VRI: • Conceptualising a Virtual Research Institute

Collaboration with International Organisations • • • • • • • Collaboration with International Funders • • • • • @jpionamr www.jpiamr.eu

Basic Science Pre-clinical Phase I Phase II Phase III Market JPIAMR EU National Science Research Agencies EC FP / ERC EC - IMI / ND4BB US BARDA US NIH / NIAID Wellcome Trust CARB-X GARDR-P EIB’s InnovFin UK / China Global Innovation Fund Existed Prior 2016 Recenly Launched

VIRTUAL RESEARCH INSTITUTE The JPIAMR Virtual Research Institute is a virtual platform to connect research networks and research performing institutes/centres to implement Antimicrobial Resistance One Health collaborative research on the JPIAMR Strategic Research Agenda priority topics by increasing knowledge, diversity, collaborations and capability. Facilitating Increasing Producing Connecting Building Global reach: Breaking access to awareness scientific AMR capacity and Bridging practical scientific and visibility evidence for researchers strengthening geographic barriers information of the AMR developing under the capability borders in the between and issue policy and JPIAMR research fields of infrastructures guidelines priority topics community research in a One Health 15 15 approach

1. Three joint research calls with a preliminary budget of 15M € • New targets, new therapies, and tools addressing the WHO pathogens priority list • Surveillance, and we will build on our recent success and support Research Networks across international borders. • First VRIs networks 2. In response to this growing AMR challenge the JPIAMR will launch a ground breaking AMR Virtual Research Institute. • International Workshops, Development plan, Pilot call 3. JPIAMR commit to increasing activities to prioritise research within the Strategic Research and Innovation Agenda to develop roadmaps, identify gaps and needs for research and actions. 4. To map AMR research funding as well as research centres/facilities and infrastructures 5. To develop a database