plc Developing Innovative Peptides Investor Presentation 30 June 2017
Disclaimer This presentation contains certain statements and may be forward-looking statements that are subject to a variety of risks and uncertainties. There are a number of important factors that could cause actual results to differ materially from those projected or suggested in any forward-looking statement made by ImmuPharma PLC (“the Company”) in respect of itself and its subsidiaries (“ImmuPharma”) . These factors include, but are not limited to: (i) ImmuPharma’s and/or ImmuPharma’s partners’ ability to successfully complete product research and development, including pre-clinical and clinical studies and commercialisation; (ii) ImmuPharma’s and/or ImmuPharma’s partners’ ability to obtain required governmental approvals, including product and patent approvals, the impact of pharmaceutical industry regulation, the difficulty of predicting FDA and other regulatory authority approvals, the regulatory environment and changes in the health policies and structure of various countries; (iii) the acceptance and demand for new pharmaceutical products and ImmuPharma’s ability to attract and/or maintain manufacturing, sales, distribution and marketing partners; and (iv) ImmuPharma’s and/or ImmuPharma’s partners’ ability to develop and commercialise products before its competitors and the impact of competitive products and pricing, the availability and pricing of ingredients used in the manufacture of products, uncertainties regarding market acceptance of innovative products newly launched, currently being sold or in development. 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Management team Tim McCarthy Dimitri F. Dimitriou Dr Robert Zimmer Chairman Chief Executive Officer Chief Scientific Officer Lisa Baderoon Dr Stéphane Méry Franco D’Muzio Tracy Weimar Non-Exec Director Head of Investor Relations Non-Exec Director VP Ops & Finance .
Today’s presentation 1. Introduction 2. Recent fundraising history 4. Update on Lupuzor ™ Phase III pivotal trial 3. Pipeline summary 5. IR strategy • Lupuzor ™ 6. Summary • Nucants • Peptide platform • Vadim Alexandre, Healthcare Analyst at Northland • Overview of ImmuPharma’s investment case Q&A
Company summary Pharma development company listed on AIM since 2006 (LSE:IMM) • • Lead drug candidate, Lupuzor TM , for the treatment of Lupus, a life threatening autoimmune disease • Phase III pivotal study ongoing • Substantial ‘blockbuster’ market potential • P140 platform with potential to target further autoimmune diseases • Nucants platform with two Phase I trials completed for potential use in combination cancer treatments and in age related macular degeneration (AMD) and diabetic retinopathy • Peptide technology platform • Longstanding collaboration with Centre National de la Recherche Scientifique (CNRS) • Europe’s largest research institution • Experienced management and research team • Low-cost business model based on outsourcing (c. 20 people)
Continued value creation 52p 52 Plac lacing 7.9m L&G, , March ’17 Price New Alto o & & Shares es New £4.1m 1m Equity ty Placing Invest estor ors 35 35p Plac lacing Oct ‘16 : 2.8m New Price New Invest estors ors £3.5m Vendor Placing & Equity Issue Shares es Including L&G 26p 26p Feb ‘16: Placing 32.8m 8m Alto Price New £8.4 million Placing & Subscription Holding Shares es Circa. . 4%
Recent IR activities : Jan to June Over Over Over 40 40 20 20 15 Presenta tati tions ons Interview ews RNS & Meeting ngs Relea eases
Investor conferences Master Biotech tech Biotech tech Investo stor & Money ey Capital ital Show -Feb- -Feb- -April-
Pipeline overview
Dimitri Dimitriou
What is Lupus? • Lupus is an autoimmune chronic inflammatory disease, sometimes fatal, associated with disorders of the immune system • Unmet market need, due to the lack of safe and effective treatments • Multi-billion sales potential • Varying patient estimates*: • an estimated 5 million people globally suffer from lupus • 1.5 million lupus sufferers in Europe/US/Japan • Current drugs have serious side-effects and limited effectiveness • GSK’s approval of Benlysta paves the path to market • ImmuPharma’s Lupuzor ™ in a pivotal Phase III trial * source: Lupus Foundation of America ‘www.lupus.org’ (2017)
Lupuzor ™ key USP’s • Novel mechanism that modulates ( not blocks ) the immune system • Phase IIb demonstrated a significant efficacy in the treatment of Lupus together with outstanding safety • Lupuzor™ granted Fast Track status by the US FDA and approval for pivotal phase III trial under Special Protocol Assessment • Attractive economics
Lupuzor ™ - mechanism of action APC with P140 Without P140 MHC-peptide- TCR Proinflammatory T cell No activation Cytokines Proinflammatory BCR B cell Cytokines No autoantibodies Damaging autoantibodies Antibody secreting cells
Lupuzor ™ phase IIb final data Lupuzor ™ Benlysta* Duration of treatment 3 months 12 months N=86 N=548 Drop-out rate % 8% / 16% 23% / 25% (active/placebo) % Responder active 62% 43% % Responder placebo 38% 33% p < 0.025 p < 0.025 Clinical impact + 25% + 10% Based on published data: Lupuzor (Zimmer et al. 2012); Benlysta (Furie et al. 2011) * Phase III study
NUCANTS & ELRO SarL Dr Robert Zimmer
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