Databases for mammography Maria Evelina Fantacci Dipar8mento di Fisica and INFN Pisa, IT 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
OUTLINE Databases for mammography: • Introduc8on (“personal”) • Historical overview • Applica8ons • Requirements • Examples of public research databases • Conclusions (“personal”) • Perspec8ves • Conclusions 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Introduc<on (“personal”) Thanks for this invita8on-opportunity to collect and evaluate the different aspects related to the topic “Databases for mammography”. • Very current, evergreen topic … … for at least the last 25 years … with ups and downs … with different meanings, contents, applica8ons … strictly related to fundamental progress in imaging instrumenta8on storage and computa8onal power so[ware development 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Introduc<on (“personal”) Other principal works but also Involved in: Collec8on of an italian mul8centric dataset of digi8zed • mammograms (end of last century-millennium). Collec8on of a pan-european dataset of digi8zed and digital • mammograms (beginning of this century-millennium). Dra[ of a book chapter about mammographic databases (few years ago). Meanwhile: physiological changes and news. This year: need for a dataset for breast density studies (RADIOMA project). No available public annotated database of digital images OK for density studies with deep learning techniques. 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview • First working groups • Digi8zed mammograms • Digital mammograms 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview 1993 US : Panel discussion, moderator F. Shtern, at IS&T/SPIE Symposium on Electronic Imaging: Science and Technology, 1993, San Jose, CA, US. SPIE Conference on Biomedical Image Processing and Biomedical Visualiza8on , 1993 Proceedings volume 1005. 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview 1994 UK: 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview 1995 US: 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Historical overview 2005 EU: The first Full Field Digital Mammography images in a research database (28 exams from Valdese Hospital, Turin. IT) 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Applica<ons • Teaching and training • Archive of par8cular cases • Sta8s8cal and epidemiological studies • Development and valida8on of so[ware analysis tools 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Teaching and training 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Teaching and training 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Teaching and training 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Teaching and training 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Archive of par<cular cases 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Archive of par<cular cases 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Sta<s<cal and epidemiological studies 2016 US: 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Sta<s<cal and epidemiological studies 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Sta<s<cal and epidemiological studies 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Sta<s<cal and epidemiological studies 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Sta<s<cal and epidemiological studies 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Development and valida<on of soQware analysis tools • CAD (Computer Aided Detec8on/Diagnosis) systems (more than 1000 pubblica8ons) • Microcalcifica8on clusters • Tumour masses • Density assessment • BIRADS classes • Segmenta8on 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems: first aTempts 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems: first aTempts Microcalcifica<on clusters 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems: first aTempts Microcalcifica<on clusters 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems: first aTempts Tumour masses 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems: first aTempts with MIAS database 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems today: recent work with mini-MIAS database 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems today: deep learning based 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems today: DREAM challenge First classified: Yaroslav Nikulin THERAPIXEL (French company) and and Yuanfang Guan (Dept. of Computa8onal Medicine and Bioinforma8cs, University of Michigan). 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems today: DREAM challenge 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
CAD systems today: synte<c images 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Density assessment A B C D ACR (American College of Radiology) breast imaging repor8ng and data system (BIRADS) 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Density assessment 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Segmenta<on: density 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Contents and requirements • Case Selec8on • Ground Truth • Associated Informa8ons • Requirements of the Digi8zers (digital images characteris8cs) • Organiza8on • Distribu8on 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
Contents and requirements 3° Training School on “Applica8on of computer models for advancement of X-ray breast imaging techniques” Napoli, IT, 17-19 September 2018
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