Biologie de la Plaque d’Athérosclérose Ziad Mallat, MD, PhD Department of Medicine, University of Cambridge, Cambridge, UK Inserm
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Pro-atherogenic Th1 vs atheroprotective Tregs Mallat et al. 2003 Tr1 cells: IL-10 Clement et al., 2018 Ait-Oufella et al. 2006 nTreg and TGF- β Herbin et al. 2012 ApoB100-Tregs Mallat et al. 1999, 2001 Hanson GK. IL-10 and TGF- β N Engl J Med 2005
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Low-dose IL-2 to limit plaque inflammation Regulation of inflammation Maintenance of Protective Immunity tolerance Stable Apoptotic debris Clearance atherosclerotic Treg Lymph node plaque IL10 Treg Teff Restablishing Healthy Balance TGF b Treg IL10 TGF b Treg Low-dose IL2 IL10 TGF b Mac. Th2 IL4 Th1 Th2 IFN g IL12 Th1 TLRs, IL12/IL18… Treg IFN g Pathogenic immunity oxLDL, Teff Unstable HSP… atherosclerotic EC Thrombus plaque Pathogenic Immunity
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2013 No CD20 CD20 mAb mAb Large infarction Small infarction Heart failure No heart failure Rituximab
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CeMM, Medical University of Cambridge Inserm U970 British Heart Foundation Paris, France University Xuan LI Hafid AIT-OUFELLA of Vienna, Austria Andy SAGE JS SILVESTRE CJ. BINDER Marc CLEMENT Alain TEDGUI Duke University, USA Thomas F. TEDDER
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How Common Is Residual Cholesterol/Inflammatory Risk?
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