cpc 1
play

CPC #1 Pathology Right lung (unfixed) Multiple nodules in left - PDF document

Mar 18, 2024 •281 likes •579 views

CPC #1 Pathology Right lung (unfixed) Multiple nodules in left lung (fixed) Left lung (fixed) Multiple Pulmonary Nodules Vascular Vasculitis (Wegeners) Pulmonary infarction Infection Bacteria Mycobacteria

  1. CPC #1 Pathology

  2. Right lung (unfixed)

  3. Multiple nodules in left lung (fixed)

  4. Left lung (fixed)

  5. Multiple Pulmonary Nodules • Vascular – Vasculitis (Wegener’s) – Pulmonary infarction • Infection – Bacteria • Mycobacteria – Fungus • Neoplasms – Primary • Benign • Malignant – Metastatic

  9. Malignant Neoplasms • Carcinomas • Sarcomas • Melanoma • Germ Cell Tumors • Leukemia/Lymphoma

  11. Characterizing an Poorly- Differentiated Malignancy • Immunohistochemistry – Stain slides with antibodies to proteins that are specific to certain cell types • Electron Microscopy – Special microscope for extremely high resolution • Genetics – Cytogenetics – Molecular Biology

  12. CD20 (B cell marker)

  13. CD20 (B cell marker)

  14. CD3 (T cell marker)

  15. Ki-67 (Proliferation marker)

  16. Diffuse Large B Cell Lymphoma Diagnosis

  17. DIAPHRAGM IMPLANT

  18. DIAPHRAGM IMPLANT

  19. EPIDIDYMIS

  20. EPIDIDYMIS

  21. HEART-RIGHT ATRIUM

  22. HEART-RIGHT ATRIUM

  23. LEFT VENTRICLE

  24. Diagnosis • Diffuse Large B Cell Lymphoma, involving – Lungs (bilateral nodules) – Middle Mediastinum – Paratesticular soft tissue (bilateral) – Diaphragm – Heart • Cardiomegaly • Atherosclerosis, Aorta

  25. Extranodal Lymphoma • Lymphoma arising outside of lymph nodes – Lymphocytes normally circulate – Found in small numbers in virtually all organs • 25% of Non-Hodgkins lymphomas are extranodal • Uncommon in Hodgkins lymphoma

  26. Common Extranodal Lymphomas • Low Grade – B cell • Mucosa Associated Lymphoid Tissue (MALT) type – Stomach (H. pylori) – Salivary gland (Sjogren’s syndrome) – Thyroid (Hasimoto’s thyroiditis) – T cell • Mycosis fungoides of skin

  27. Common Extranodal Lymphomas (cont) • High Grade – B cell • Diffuse Large B Cell Lymphoma – Common sites include lung, GI tract, CNS – Can be solitary or multifocal – Can be associated with immunosuppression • Burkitt lymphoma – Commonly involves ileocecal area in children – T cell • Peripheral T Cell Lymphomas

  28. Summary-Key Points • Diffuse Large B Cell Lymphoma is the most common high grade extranodal lymphoma • Differential diagnosis of disseminated malignancy • Immunohistochemistry can be used to characterize a poorly-differentiated malignancy

Recommend

More recommend