Co-receptor diagnosis – the clinical perspective CORUS Co-receptor usage as a marker for specific HIV diagnostics with high sensitivity
CXCR4 CORUS
CORUS
CORUS
MARAVIROC
Genotypic assay
Moyle 2005 JID 191;866-72 TROFILE
TROFILE
TROFILE
Trofile - drawbacks • No detection of minority variant populations • Testing only in California or France • Labor intensive and expensive • Time consuming
CORUS – research goals Development of diagnostic assay for selective detection of X4-tropic minorities in HIV-1-infection Strengths of a new assay should include: • Fast and easy performance • Applicability in vitro • Suitability for routine diagnostics
CORUS - Subprojects Univ. Cologne GSH Univ. Duisburg-Essen Univ. Düsseldorf SIEMENS HZI DIAGNOSTICS
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