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BETTER THAN PROZAC: TRANSLATING THE NEW BRAIN SCIENCE INTO - PowerPoint PPT Presentation

BETTER THAN PROZAC: TRANSLATING THE NEW BRAIN SCIENCE INTO GREATER CLINICAL RESULTS Bill OHanlon 12.08 NICABM The New Brain Science The New Brain Science Old view: Brain had fixed structure and set number of brain cells, which


  1. SMILE (Standard Medical Intervention and Long Term Exercise) How much exercise matters: Every 50 minutes of exercise per week correlated with a 50 % drop in depression levels “ Exercise and Pharmacotherapy in the T reatment of Major Depressive Disorder,” James A. Blumenthal, PhD et. al, Psychosomatic Medicine, 69:587 - 596 ( 2007 ) .

  2. Exercise and Mood: Depression research

  3. Exercise and Mood: Depression research Two studies found:

  4. Exercise and Mood: Depression research Two studies found: • People who participated in moderately intense aerobics , such as exercising on a treadmill or stationary bicycle - whether it was for three or five days per week - experienced a decline in depressive symptoms by an average of 47 % after 12 weeks

  5. Exercise and Mood: Depression research Two studies found: • People who participated in moderately intense aerobics , such as exercising on a treadmill or stationary bicycle - whether it was for three or five days per week - experienced a decline in depressive symptoms by an average of 47 % after 12 weeks • Those in the low - intensity exercise groups showed a 30 % reduction in symptoms

  6. Exercise and Mood: Depression research Two studies found: • People who participated in moderately intense aerobics , such as exercising on a treadmill or stationary bicycle - whether it was for three or five days per week - experienced a decline in depressive symptoms by an average of 47 % after 12 weeks • Those in the low - intensity exercise groups showed a 30 % reduction in symptoms • Exercise also helped people who were unresponsive to medications

  7. Exercise and Mood: Depression research Two studies found: • People who participated in moderately intense aerobics , such as exercising on a treadmill or stationary bicycle - whether it was for three or five days per week - experienced a decline in depressive symptoms by an average of 47 % after 12 weeks • Those in the low - intensity exercise groups showed a 30 % reduction in symptoms • Exercise also helped people who were unresponsive to medications T rivedi, M.H., Greer, T.L., Grannemann, B.D., Chambliss, H.O., Jordan, A.N, “Exercise as an Augmentation Strategy for T reatment of Major Depression.” Journal of Psychiatric Practic e , 12 ( 4 ) :205 - 13, 2006

  8. Exercise and Mood: Depression research Two studies found: • People who participated in moderately intense aerobics , such as exercising on a treadmill or stationary bicycle - whether it was for three or five days per week - experienced a decline in depressive symptoms by an average of 47 % after 12 weeks • Those in the low - intensity exercise groups showed a 30 % reduction in symptoms • Exercise also helped people who were unresponsive to medications T rivedi, M.H., Greer, T.L., Grannemann, B.D., Chambliss, H.O., Jordan, A.N, “Exercise as an Augmentation Strategy for T reatment of Major Depression.” Journal of Psychiatric Practic e , 12 ( 4 ) :205 - 13, 2006 Andrea L. Dunn, Madhukar H. T rivedi, James B. Kampert, Camillia G. Clark and Heather O. Chambliss, “Exercise treatment for depression: E ffi cacy and dose response,” America n Journal of Preventive Medicin e , V olume 28, Issue 1, January 2005, Pages 1 - 8

  9. Exercise and Mood: Depression research

  10. Exercise and Mood: Depression research A Purdue University study found:

  11. Exercise and Mood: Depression research A Purdue University study found: Middle - aged runners who had been running 3 - 5 times/week for 3 - 10 years were markedly less depressed than a matched comparison group.

  12. Exercise and Mood: Depression research A Purdue University study found: Middle - aged runners who had been running 3 - 5 times/week for 3 - 10 years were markedly less depressed than a matched comparison group.

  13. Exercise and Mood: Depression research A Purdue University study found: Middle - aged runners who had been running 3 - 5 times/week for 3 - 10 years were markedly less depressed than a matched comparison group. D. Lobstein et al., “Depression as a Powerful Discriminator Between Physically Active and Sedentary Middle - Aged Men,” Journal of Psychosomatic Medicine, 27 ( 1983 ) :69 - 76.

  14. Exercise and Mood: Depression research

  15. Exercise and Mood: Depression research A University of Virginia study found:

  16. Exercise and Mood: Depression research A University of Virginia study found: • Exercise had the most profound mood - lifting e fg ect on people who were depressed

  17. Exercise and Mood: Depression research A University of Virginia study found: • Exercise had the most profound mood - lifting e fg ect on people who were depressed • The e fg ect increased with the amount of exercise

  18. Exercise and Mood: Depression research A University of Virginia study found: • Exercise had the most profound mood - lifting e fg ect on people who were depressed • The e fg ect increased with the amount of exercise • The study also found reductions in anger and anxiety through exercise

  19. Exercise and Mood: Depression research A University of Virginia study found: • Exercise had the most profound mood - lifting e fg ect on people who were depressed • The e fg ect increased with the amount of exercise • The study also found reductions in anger and anxiety through exercise R. Brown et. al ( 1978 ) . “The Prescription of Exercise for Depression,” Physician and Sportsmedicin e , 6:34 - 49.

  20. Exercise and Moods: Depression research

  21. Exercise and Moods: Depression research Beware of “overtraining,” or exercising too much ( as in anorexia and other compulsive problems )

  22. Exercise and Moods: Depression research Beware of “overtraining,” or exercising too much ( as in anorexia and other compulsive problems ) • The evidence shows that over - exercising ( exercising several times a day at training levels that are at or near maximal ) is correlated with depressed moods

  23. Exercise and Moods: Depression research Beware of “overtraining,” or exercising too much ( as in anorexia and other compulsive problems ) • The evidence shows that over - exercising ( exercising several times a day at training levels that are at or near maximal ) is correlated with depressed moods W . Morgan et. al ( 1991 ) . “Psychological Monitoring of Overtraining and Staleness,” British Journal of Sports Medicin e , 12:146 - 59.

  24. Exercise and Moods: Depression research Beware of “overtraining,” or exercising too much ( as in anorexia and other compulsive problems ) • The evidence shows that over - exercising ( exercising several times a day at training levels that are at or near maximal ) is correlated with depressed moods W . Morgan et. al ( 1991 ) . “Psychological Monitoring of Overtraining and Staleness,” British Journal of Sports Medicin e , 12:146 - 59.

  25. Dr. John Ratey on exercise and mood disorders • Serotonin, dopamine, norepinephrine levels and regulation a ff ected by exercise

  26. Exercise and Mood: Anxiety research

  27. Exercise and Mood: Anxiety research A review of 56 empirical studies found:

  28. Exercise and Mood: Anxiety research A review of 56 empirical studies found: 73 % of those studies showed significant reductions of anxiety following exercise

  29. Exercise and Mood: Anxiety research A review of 56 empirical studies found: 73 % of those studies showed significant reductions of anxiety following exercise Single bouts of exercise associated with decreased state anxiety

  30. Exercise and Mood: Anxiety research A review of 56 empirical studies found: 73 % of those studies showed significant reductions of anxiety following exercise Single bouts of exercise associated with decreased state anxiety Extended programs of regular exercise associated with reduced trait anxiety

  31. Exercise and Mood: Anxiety research A review of 56 empirical studies found: 73 % of those studies showed significant reductions of anxiety following exercise Single bouts of exercise associated with decreased state anxiety Extended programs of regular exercise associated with reduced trait anxiety Leith, L. ( 1994 ) . Foundations of Exercise and Mental Health. Morgantown, WV: Fitness Information Technology.

  32. Exercise and Mood: Anxiety research

  33. Exercise and Mood: Anxiety research A study compared the e ff ects of aerobic cycling to weight training:

  34. Exercise and Mood: Anxiety research A study compared the e ff ects of aerobic cycling to weight training: Blood pressure and state anxiety fell significantly after cycling

  35. Exercise and Mood: Anxiety research A study compared the e ff ects of aerobic cycling to weight training: Blood pressure and state anxiety fell significantly after cycling Blood pressure and state anxiety increased significantly after weight training

  36. Exercise and Mood: Anxiety research A study compared the e ff ects of aerobic cycling to weight training: Blood pressure and state anxiety fell significantly after cycling Blood pressure and state anxiety increased significantly after weight training Raglin, J. ( 1997 ) . “ Anxiolytic E ff ects of Physical Activity,” in Physical Activity and Mental Health , ed. W . Morgan ( W ashington, DC: Taylor and Francis ) , p. 113.

  37. Exercise and Mood: Anxiety research

  38. Exercise and Mood: Anxiety research A study compared the e ff ects of exercising at 60 % of maximum heart rate to 70 - 75 % ( 3x/week ) over 10 weeks :

  39. Exercise and Mood: Anxiety research A study compared the e ff ects of exercising at 60 % of maximum heart rate to 70 - 75 % ( 3x/week ) over 10 weeks : • Significant reductions in trait anxiety for the 60 % group

  40. Exercise and Mood: Anxiety research A study compared the e ff ects of exercising at 60 % of maximum heart rate to 70 - 75 % ( 3x/week ) over 10 weeks : • Significant reductions in trait anxiety for the 60 % group • No reductions for the 70 - 75 % group

  41. Exercise and Mood: Anxiety research A study compared the e ff ects of exercising at 60 % of maximum heart rate to 70 - 75 % ( 3x/week ) over 10 weeks : • Significant reductions in trait anxiety for the 60 % group • No reductions for the 70 - 75 % group Moses, J. et. al ( 1989 ) . “The E ff ects of Exercise T raining on Mental W ell Being in the Normal Population,” Journal of Psychosomatic Research , 33:47 - 61.

  42. Exercise and Mood: Anxiety research

  43. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study:

  44. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment

  45. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment • 36 had anxiety disorders ; stopped all meds during this hospital stay

  46. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment • 36 had anxiety disorders ; stopped all meds during this hospital stay • Hour of aerobic exercise 5 days/week for 8 weeks

  47. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment • 36 had anxiety disorders ; stopped all meds during this hospital stay • Hour of aerobic exercise 5 days/week for 8 weeks • Anxiety scores decreased in all patients except those with social anxiety

  48. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment • 36 had anxiety disorders ; stopped all meds during this hospital stay • Hour of aerobic exercise 5 days/week for 8 weeks • Anxiety scores decreased in all patients except those with social anxiety • One - year follow - up showed those with GAD and agoraphobia w/o panic attacks maintained treatment gains

  49. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment • 36 had anxiety disorders ; stopped all meds during this hospital stay • Hour of aerobic exercise 5 days/week for 8 weeks • Anxiety scores decreased in all patients except those with social anxiety • One - year follow - up showed those with GAD and agoraphobia w/o panic attacks maintained treatment gains

  50. Exercise and Mood: Anxiety research Norwegian psychiatrist Egil Martinsen did a study: • 92 patients voluntarily committed themselves to a hospital for 8 weeks ; variety of diagnoses but had failed to benefit from outpatient treatment • 36 had anxiety disorders ; stopped all meds during this hospital stay • Hour of aerobic exercise 5 days/week for 8 weeks • Anxiety scores decreased in all patients except those with social anxiety • One - year follow - up showed those with GAD and agoraphobia w/o panic attacks maintained treatment gains Martinsen, E. et. al ( 1989 ) . “ Aerobic and non - aerobic forms of exercise in the treatment of anxiety disorders,” Nordic Journal of Psychiatry , 43:411 - 415.

  51. Exercise and ADHD

  52. Exercise and ADHD • Exercise has been shown to elevate dopamine levels in the brain, as well as increase dopamine storage

  53. Exercise and ADHD • Exercise has been shown to elevate dopamine levels in the brain, as well as increase dopamine storage • Exercise also increases the production of enzymes that create dopamine receptors in the reward centers of the brain

  54. Exercise and ADHD • Exercise has been shown to elevate dopamine levels in the brain, as well as increase dopamine storage • Exercise also increases the production of enzymes that create dopamine receptors in the reward centers of the brain • Dopamine improves mood and motivation and increases attentional abilities

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