Aris Floratos (Flash talk) & Kenneth Smith (Demo) Columbia - PowerPoint PPT Presentation

Aris Floratos (Flash talk) & Kenneth Smith (Demo) Columbia University

MAGNet : National Center for the Multiscale Analysis of Genomic and Cellular Networks: http://magnet.c2b2.columbia.edu Integrated access to MAGNet Center and 3rd party tools. Java, open source, extensible platform. 70+ analytical and visualization modules. http://www.geworkbench.org

3 new geWorkbench modules (data and tools from Andrea Califano’s lab @ Columbia) : Querying interface for computational LINCS Drug synergy predictions and experimental Synergy Data validation assays (Mariano Alvarez) Virtual Inference of Protein-activity VIPER by Regulon Readout (Mariano Alvarez) Drug Mechanism of Action using DeMAND Network Dysregulation (Yishai Shimoni)

Step 1 : Interactome construction. ARACNe Public GE data Step 2 : Identification of differentially expressed genes. Vs. Differentially expressed genes LINCS Cell Line LINCS Cell Line (untreated) (Drug D treated)

Step 3 : Inference of drug functional mechanism of action. G1 G2 G3 fMoA (Drug D) = {G1, G2, G3}

geWorkbench dev team Califano Lab • Kenneth Smith • Andrea Califano • Zhou Ji • Mariano Alvarez • Meng Wang • Mukesh Bansal • Min You • Gabrielle Rieckhof • Michael Honig National Centers for Biomedical Computing