Answering some tough questions tool 1. Relationship and value of - PDF document

Kelli Retallick, Angus Genetics Inc. June 19, 2019 Navigating a new frontier: Pulmonary Arterial Pressure Kelli Retallick, M.S. – AGI Genetic Service Director Saint Joseph, Missouri Path to a genetic selection Answering some tough questions tool 1. Relationship and value of PAP 2013 20 Fe Feb. 2019 July 2019 Ju PAP score measurements at elevations Research report Cut-off for collection began release data by at the members Association 2. PAP and growth traits in Angus cattle 3. PAP and ultrasound carcass traits in Angus cattle Spring 2019 Sp 2016 20 Summer 2018 Su Fa Fall 2019 Research to Collaboration with Pauling thesis Production EPD incorporate Colorado State peer reviewed release for additional data University and published yearling PAP Collaboration with Colorado State Important take-aways from Pauling University Number of records = 14,665 • Combined records from 3 locations A logical break in PAP measurements where • High elevation vs. mean PAP starts to Moderate elevation increase due to elevation is 1,620m (5,250 ft) • High correlation among the two scores Efficiency and Adaptability Committee, 2019 BIF Symposium, Brookings, S.D. 1

Kelli Retallick, Angus Genetics Inc. June 19, 2019 Strong correlation between the high No strong correlations between PAP and moderate elevation records with growth and carcass traits HPAP HP MPAP MP HP HPAP 0.34 0.83 (0.03) (0.15) MP MPAP 0.29 (0.09) Path to a genetic selection Modelling the new trait: PA PAP EPD tool • Trait being predicted: Hi High Altitude Yearling PAP • Ag Age ~ covariate 20 2013 Fe Feb. 2019 July 2019 Ju PAP score Research report Cut-off for collection began – 320 – 720 days of age release data by at the members Association • El Elevation ~ covariate – Continuous • Co Contemporary group: he herd/sex/test date/elevation ~ fixed effect • Mo Moderate elevation PAP score ~ correlated trait Sp Spring 2019 2016 20 Su Summer 2018 Fall 2019 Fa Research to Collaboration with Pauling thesis Production EPD (based on work by Pauling et al., 2018) incorporate Colorado State peer reviewed release for additional data University and published yearling PAP • Ge Genomics – Single-Step Genetic Evaluation Elevation breaks for incorporation into national cattle evaluation • High altitude: 5,500 ft or greater • Moderate altitude: 4,000 to <5,500 ft No No. of Actual Ac Edited Ed Al Altitude He Heritability Records Re Sc Scores Da Data High Hi 4,200 28-180 30-80 0.32 Mo Moderate 1,500 25-139 30-80 0.16 r 2= 2= 0. 0.80 80 Efficiency and Adaptability Committee, 2019 BIF Symposium, Brookings, S.D. 2

Kelli Retallick, Angus Genetics Inc. June 19, 2019 Future work: Incorporation of Progress with Research EPD weaning PAP measurements Ben Benef efits: • Additional data captured • Avoid pre-selection bias into – 2,631 high elevation records the evaluation – 896 moderate elevation records • Include increased number of records with a high correlation Current Si Cu Sires = Registered Progeny within last 2 Years • Number of records Me Mean EP EPD St Std. Dev. Minimum Mi Maximum Ma – ~ 3,000 total – ~1,000 with both weaning and -0.29 0.85 -3.63 5.86 yearling PAP at high altitudes Path to a genetic selection Production PAP EPD to be released tool Late 2019 20 2013 Feb. 2019 Fe Ju July 2019 PAP score Research report Cut-off for collection began released data by at the members Association Spring 2019 Sp 2016 20 Su Summer 2018 Lat Late 2019 Research to Collaboration with Pauling thesis Production EPD incorporate Colorado State peer reviewed release for additional data University and published yearling PAP The value of PAP scoring will not diminish: education is key • A PAP EPD is not a replacement to the actual scoring of animals to send to higher elevations • The value of a PAP EPD, just like any EPD, is Questions & Discussion to identify parents for the next generations Dan W. Moser, Ph.D. AGI President • Inclusion of genomics allows high altitude dmoser@angus.org 816-383-5196 breeders to identify bulls to utilize in Stephen Miller, Ph.D. Genetic Research Director smiller@angus.org 816-383-5157 breeding programs with less risk . Kelli Retallick, M.S. Genetic Service Director kretallick@angus.org 816-383-5190 Thank you for joining us! Efficiency and Adaptability Committee, 2019 BIF Symposium, Brookings, S.D. 3