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An Integrated View into Multivariate Associations Inferred from TCGA Cancer Data Dick Kreisberg Institute for Systems Biology Shmulevich Group Nov 17, 2011 Visual Analytics Emergent Technologies Browser-based

An Integrated View into Multivariate Associations Inferred from TCGA Cancer Data Dick Kreisberg Institute for Systems Biology Shmulevich Group Nov 17, 2011
Visual Analytics
• • • • • Emergent Technologies Browser-based Graphical Rendering – SVG, Canvas, WebGL, Flash Cloud Services – Highly available, scale-able NoSQL (Couch, Mongo, etc) – Adaptive data models Graph Databases (Neo4J, OrientDB) – Adaptive data relationships Graph Computation – Reasoning on the topology of the data 3
Integrating Data Across Sources, Analyses, and Literature http://explorer.cancerregulome.org
Random Forest Analysis Regulome Explorer Genome View –RF, Significant Pairs, Aggressiveness Timo Erkkila
Colorectal Aggressiveness Scoring Vesteinn Thorsson
All Pairs Significance Sheila Reynolds, Thomas Robinson
Exploring the Association Topology Regulome Explorer Network View – Semantic, Protein Domain, RF Edges Brady Bernard, Andrea Eakin
Future Work Graph Databases Graph Computation Network Topologies Explicit, Retrievable State User Data Import 9
http://explorer.cancerregulome.org Ilya Shmulevich Analysis Vesteinn Thorsson Genome View Sheila Reynolds Jake Lin Technologies Timo Erkkila Dick Kreisberg Protovis Acknowledgements Network View ExtJS Hector Rovira Google Visualization API Andrea Eakin Cytoscape Web Ryan Bressler Brady Bernard Neo4J Adam Norberg Golem Thomas Robinson The project described was supported by Award Number U24CA143835 from the National Cancer Institute. 10

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