Abstract ID: 12 Presenting Author: Saranya Devi K Co-Authors: - PDF document

Abstract ID: 12 Presenting Author: Saranya Devi K Co-Authors: Anushree Mishra Anita Ganger Rohit Saxena Madhulika Kabra Abstract Title: Evaluation of the effect of secondary mitochondrial DNA mutations in Leber’s hereditary optic neuropathy(LHON) patients Abstract Topic: Free Paper Poster Podium Presentation, 3 min talk + 1 min discussion ABSTRACT: BACKGROUND & OBJECTIVES LHON has three primary mutations. The significance of secondary mutation m.11719A on disease severity and treatment outcomes of LHON was studied. MATERIAL & METHODS Study included 39 patients. visual acuity, fundus examination, pupils , colour vision ,Visual evoked response (VER), retinal nerve fibre layer thickness(RNFL), retinal ganglion cell layer thickness (GCL) were evaluated before therapy and after 24 weeks. RESULTS Eyes with primary G11778A mutation alone were group 1 , those with secondary G17119A mutation were group 2 and those with both were group 3. Group 3 had more chances of disc pallor and colour vision abnormality .Group 3 eyes had significantly thinner GCL than Group 2 . CONCLUSION G11719A is a possible secondary mutation that might act synergistically with primary mutations in hastening disease process. REFERENCES Meyerson C, Van Stavern G, McClelland C. Leber hereditary optic neuropathy: current perspectives. Clin Ophthalmol. 2015 Jun 26; 9:1165-76

Abstract ID: 20 Presenting Author: Benita Jayachandran Co-Authors: Juhy Cherian Elfride Farokh Sanjana Rajalakshmi.S Abstract Title: Blinding Mucor attacks with fervour-A Case series Abstract Topic: Free Paper Poster Podium Presentation, 3 min talk + 1 min discussion ABSTRACT: Background and objectives: Mucormycosis is an acute fatal infection caused by of Mucoraceaefamily, most common being of the Rhizopus species.To report a case series of Rhino-Orbito-Cerebral Mucormycosis Methods and material: Three patients ofRhino-Orbito-Cerebral Mucormycosis presented with sudden loss of vision,ophthalmoplegia,Central Retinal Artery Occlusion and uncontrolled Diabetes Mellitus Results: Histopathological examination- angioinvasivebroad aseptate fungal hyphae consistent withmucormycosis. Neuroimaging- palatal defect,pansinusitis, extension of lesion into the orbit.Patients were treated with appropriate antifungalsand surgical debridement was done. Visual outcome remained poor. Conclusion: Early detection,antifungal therapy,control of risk factorsand timely surgical debridement in appropriate cases are the main parameters of successful management of mucormycosis. References Mohammadi R, Meidani M, Mostafavizadeh K, et al. Case series of rhinocerebralmucormycosisoccurring in diabetic patients Caspian Journal of Internal Medicine . 2015;6(4):243-246. Oladeji S, Amusa Y, Olabanji J, Adisa A. rhinocerebralmucormycosis in a diabetic case report. journal of the west african college of surgeons . 2013;3(1):93-102.

Abstract ID: 30 Presenting Author: Preeti Patil Chhablani Co-Authors: Rajat Kapoor Ashik Mohamed Akshay Badakere Virender Sachdeva Ramesh Kekunnaya Vivek Warkad Abstract Title: Visual field defects in the ‘normal’ fellow eye in unilateral traumatic optic neuropathy Abstract Topic: Free Paper Poster Podium Presentation, 3 min talk + 1 min discussion ABSTRACT: Background and Objectives: Traumatic optic neuropathy (TRON) is usually unilateral; however, the apparently normal fellow eye may harbor visual field defects (VFDs). This study aims to evaluate VFDs in the unaffected eye in unilateral TRON. Methods: One-hundred-and-ninety patients with unilateral TRON were included. Visual fields (VFs) were tested using Humphrey SITA 30-2 program. The effect of clinical factors such as head trauma, cranial nerve involvement, orbital fractures, intracranial bleed and fractures, etc. was analyzed. Results: Eighty-one (42.6%) had VFDs. Presence of multiple orbital and cranial bone fractures was significantly associated with the presence of VFD (p=0.0003; odds-ratio 3.33). On VFD subtype analysis, chiasmal and post-chiasmal defects were significantly present (p=0.04; odds-ratio 2.79). Conclusion: VF was affected in 43% of ‘normal’ fellow eyes after unilateral TRON. Multiple orbital and cranial fractures are significant risk factors for involvement of the VF.TRON patients are more likely to have chiasmal or retrochiasmal pattern of VF loss in the normal eye

Abstract ID: 45 Presenting Author: Varshini Shanker Co-Authors: Abstract Title: Co-relation of improvement in visual acuity with change in RNFL thickness in Ethambutol induced optic neuropathy Abstract Topic: Free Paper Poster Podium Presentation, 3 min talk + 1 min discussion ABSTRACT: BACKGROUND & OBJECTIVES Ethambutol induced optic neuropathy occurs in 1-5% of patients even with standard dosage. MATERIAL & METHODS A prospective observational case series of 10 patients with Ethambutol induced toxic neuropathy within 6 weeks of onset of vision loss. OCT- RNFL was performed at initial diagnosis and after follow up of minimum 6 months. Vision, colour vision, visual fields, VEP and optic disc photo was noted in all cases. RESULTS All patients showed a statistically significant improvement in vision in both eyes though course of visual recovery and duration taken was unpredictable.. There was a statistically significant decrease in the mean RNFL of all quadrants with the greatest decrease in temporal quadrant. Good recovery of vision was seen in patients with minimal decrease in RNFL.Poor recovery co-related with severe decrease in RNFL thickness in the temporal quadrant. CONCLUSION OCT may serve as a useful tool to objectively quantify changes in RNFLT and to monitor clinical progression in patients with toxic optic neuropathy. A stable RNFL thickness is predictive of better improvement in vision. REFERENCES 1. Kee C, Hwang JM. Optical coherence tomography in a patient with tobacco-alcohol amblyopia. Eye (Lond) 2008;22:469 – 70. 2.Chai SJ, Foroozan R. Decreased retinal nerve fibre layer thickness detected by optical coherence tomography in patients with ethambutol-induced optic neuropathy. Br J Ophthalmol. 2007;91:895 – 7.

Abstract ID: 49 Presenting Author: Sujata Guha Co-Authors: Satish Sharma Shruti Mittal MD Shahid Alam Siddharth Sheth Abstract Title: Clinical profile and management outcome of traumatic optic neuropathy Abstract Topic: Free Paper Poster Podium Presentation, 3 min talk + 1 min discussion ABSTRACT: BACKGROUND & OBJECTIVES: To evaluate clinical profile and management outcome of traumatic optic neuropathy. MATERIAL & METHODS: Retrospective analysis of all cases diagnosed with traumatic optic neuropathy between 2013 to 2017 was done. RESULTS: There were a total of 107 patients with male predominance (91,85%). Road traffic accident was the most common cause seen in 81% of cases. RAPD was present in 104 eyes (97%). Majority of patients had no perception of light at presentation. 44 patients (41%) were treated with steroids while 63 (59%) were just observed. There was no significant difference in the management outcomes in both the groups. CONCLUSION:There is no difference (P=0.55) in the management outcome of traumatic optic neuropathy whether managed with steroids or with observation. REFERENCES: 1. Pokharel S, Sherpa D, Shrestha R, Shakya K, Shrestha R, Malla OK, PradhanangaCL, Pokhrel RP, Shrestha P. Visual Outcome after Treatment with High DoseIntravenous Methylprednisolone in Indirect Traumatic Optic Neuropathy. J NepalHealth Res Counc. 2016 Jan;14(32):1-6. 2. Entezari M, Rajavi Z, Sedighi N, Daftarian N, Sanagoo M. High-dose intravenous methylprednisolone in recent traumatic optic neuropathy; a randomized double-masked placebo-controlled clinical trial. Graefes Arch ClinExpOphthalmol. 2007 ep;245(9):1267-71.

3. Lee KF, MuhdNor NI, Yaakub A, Wan Hitam WH. Traumatic optic neuropathy: a review of 24 patients. Int J Ophthalmol. 2010;3(2):175-8.

Abstract ID: 58 Presenting Author: Jyoti Himanshu Matalia Co-Authors: Hemant Anaspure Bhujang Shetty Abstract Title: OUTCOMES OF OPTIC NERVE SHEATH DECOMPRESSION FOR VISUAL LOSS SECONDARY TO RAISED INTRACRANIAL PRESSURE Abstract Topic: Free Paper Poster Podium Presentation, 3 min talk + 1 min discussion ABSTRACT: (max. 1000 characters) BACKGROUND & OBJECTIVES: Persistently high intracranial hypertension usually leads to visual loss due to chronic papilloedema. Optic nerve sheath decompression (ONSD) has been shown to improve or stabilize vision in such patients. We report our experience of ONSD for visual loss. MATERIAL & METHODS: Retrospective analysis of all patients who underwent ONSD for persistent papilledema with visual acuity and/or field loss inspite of maximum therapy for raised intracranial pressure. All patients had minimum 6 weeks of follow up. RESULTS: Total 34 eyes of 17 patients were included. Following ONSD, visionimproved in 8(23.53%), stabilized in 26(76.47%)of the total 34 eyes. Among the 10 eyes in whom the visual fields (VF) were done it stabilised or improved in 9. Flattening of optic disc was noted in all at the end of 5 weeks.No major complication was noted. CONCLUSION: ONSD is safe and effective method to preserve visual field and or acuity loss due to papilloedema during early postoperative period.