A NETWORK PERSPECTIVE ON COMORBID DEPRESSION IN ADOLESCENTS WITH - PowerPoint PPT Presentation

A NETWORK PERSPECTIVE ON COMORBID DEPRESSION IN ADOLESCENTS WITH OCD Payton J. Jones, Patrick Mair, Bradley C. Riemann, Beth L. Mugno, & Richard J. McNally

OCD & Depression • Very common for those with OCD (62.7-78.2% life<me; Millet et al., 2004) • OCD generally comes first (Ricciardi & McNally, 1995) • Associated with greater severity (Brown et al., 2015) • Elevated suicide risk (Torres et al., 2011) • Linked to obsessions, but not compulsions (Ricciardi & McNally, 1995; Besiroglu et al., 2007)

Common cause model Cramer, A., Waldorp, L., Van der Maas, H., & Borsboom, D. (2010). Behavioral and Brain Sciences

Network view Cramer, A., Waldorp, L., Van der Maas, H., & Borsboom, D. (2010). Behavioral and Brain Sciences

Edges Nodes Communi<es

Rela<onships between symptoms Edges Symptoms Nodes Disorders Communi<es

Centrality • Strength

Centrality • Strength • Betweenness

Centrality • Strength • Betweenness • Closeness

Correla<on Network r > 0.25

Graphical LASSO (sparse par<al correla<ons) γ = 0.3

Graphical LASSO (Sparse par<al correla<ons) Betweenness Closeness Strength weightloss ● ● weightgain ● ● ● suicide ● ● ● sad ● ● ● retard ● ● ● onset ● ● ● obtime ● ● ● obresist ● ● ● obinterfer ● ● ● obdistress ● ● ● obcontrol ● ● ● middle ● ● ● late ● ● ● incappetite ● ● ● hypersom ● ● guilt ● ● ● fatigue ● ● ● decappetite ● ● concen ● ● ● comptime ● ● ● compresis ● ● ● compinterf ● ● ● compdis ● ● ● compcont ● ● ● anhedonia ● ● ● agitation ● ● ● 0 1 2 3 − 2 − 1 0 1 2 − 1 0 1

Conclusions • Central symptoms – Obsessions, sadness, concentra<on problems • Communi<es with bridges – Obsessions, guilt, sadness, concentra<on problems • Concentra<on problems are unique Two most common func<onal complaints (Piacen<ni et al., 2003): • Problems concentra<ng on schoolwork • Doing homework • • Networks and the future

Thank you for your aben<on!

Addi<onal Resources • Read the preprint: hbps://osf.io/preprints/psyarxiv/8d9kx • Adding non-symptom nodes to networks: • hbps://osf.io/preprints/psyarxiv/sv58b/ • hbps://osf.io/preprints/psyarxiv/mh3cf/ • ResearchGate: www.researchgate.net/profile/Payton_Jones • Helpful network tutorials: hbp://psych-networks.com/tutorials/ • networktools R package: hbps://cran.r-project.org/web/packages/networktools/ networktools.pdf