1 Acuitas Medical, Swansea, United Kingdom, 2 University Hospital - PowerPoint PPT Presentation

1 Acuitas Medical, Swansea, United Kingdom, 2 University Hospital Llandough, United Kingdom, 3 University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, 4 Swansea University, Swansea, United Kingdom

Selective 1D highly sampled, Inverse Fourier Fourier based excitation of spatially encoded transform echo analysis of profile internal volume - complex echoes gives 1D signal within region of “prism” - through along r . intensity profile as interest gives fine modified pu lse function of position structure spectra – Multiple sequence. along the prism. Noise and repetitions. confidence interval → Significant signal Define regions of calculations from advantage over intere st. multiple imaging . repetitions. -6 2.5 x 10 Spectrum 2 Mean Noise 68% CI Intensity 1.5 Magnitude 1 r 0.5 r fine SA 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 Structural wavelength (mm) MRI 0 “voxel” 0 20 40 60 80 100 120 140 Position along prism (mm) voxel

0 0.5 1 1.5 2 Structural Wavelength (mm)

• The study was run at the University of Cambridge Wolfson Brain Imaging Centre using a Siemens 3T MRI scanner. • Cohort: • All patients were recruited from Professor Juliet Compston’s clinic at Addenbrookes Hospital. • 20 post-menopausal women aged >55 years. • Not receiving treatment with Teriparatide, Strontium Ranelate, or intra- venous bisphosphonates. • Not been treated with oral bisphosphonates for longer than six months • Had undergone DXA scan to assess bone health. • 6 classified as normal by DXA using WHO criterion, 6 classified as osteopenic, 8 classified as osteoporotic.

SI AP ML ML SI AP

t -0.4 Age 23 normal t -1.9 Postmenopausal osteoporotic t -2.8 Age matched normal BMD 0.0 0.5 1.0 1.5 2.0 2.5 0.0 0.5 1.0 1.5 2.0 2.5 Structural wavelength (mm) Structural wavelength (mm)

Hip M/L Hip A/P Spine S/I Spine M/L fineSA fineSA fineSA fineSA Correlation r=-0.5316 r= 0.5787 r= 0.4705 r=0.5318 with T- p=0.0192 p=0.0075 p=0.0363 p=0.0158 Score

• Sensitive to changes in bone • Current resolution around 0.3mm • 1 minute acquisition • Ionising radiation free • Applicable to the central skeleton • No additional hardware required

• A larger in-vivo study led by Dr. Diego Martin is underway with University of Arizona, Tucson. • A two centre study of treatment induced bone loss in oncology patients is underway in the US and UK. • A version of the tool is slated for release at the end of this year.