THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET Science Market Regulation UBIC CONSULTING 2 0 1 5 Marketing development Strategy consulting Partnership searches Information systems
350 pages SCIENCE – MARKET – REGULATION - MANUFATURERS This comprehensive report is based on in-depth interviews with food companies completed by a desk review. It provides for DECISION MAKERS a global understanding of the sector as well as an outlook on its future. MARKET ANALYSIS FOOD SEGMENTS New trends and perspectives Food industry Use of ingredients: volumes-value Cosmetics Manufacturers profiles Pharmacy User’s opinion Industrial markets Regulation INGREDIENTS COUNTRIES COVERED North America Lactoferrin Western and Eastern Europe Lactoperoxidase Asia Australia- New Zealand
350 pages SCIENCE – MARKET – REGULATION - MANUFATURERS O B J E C T I V E S M A R K E T Industrial users needs, expectations and volumes Applications in segments and consumption trends Consumer market trends by food segments Prospective and forecast M A N U F A T U R E R S Processes and capacities Market share Company description R E S E A R C H New researches and developments New applications
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET INTRODUCTION O B J E C T I V E S Lactoferrin concentration in different It is now over 40 years since lactoferrin was sources first isolated. Lactoferrin, which belongs to the M A R K E T transferring family of proteins, is a 70-80 kDa Bovine milk 200 mg/l single sub-unit glycoprotein and consist of two domains, each with one iron-binding site that Industrial users needs, requires synergistic binding of a bicarbonate expectations and volumes Bovine colostrum 1g/l anion. A conformational change in the binding site, between open or closed forms, accompanies Applications in segments iron binding and release. The affinity of and consumption trends Human milk 2-4 g/l lactoferrin for iron is much greater than of transferrin which functions as an iron carrier in Consumer market trends by serum. In the “natural state”, lactoferrin is only food segments Human colostrum 6-8 g/l partly saturated with iron (5-30%) and has a salmon color, the intensity of which depends on Prospective and forecast the degree of iron saturation. M A N U F A T U R E R S It is present in human milk, and many exocrine This enzyme is primarily found in such exocrine fluids (saliva, mucous secretion) as well as secretions as saliva, lachrymal fluid and milk, mammalian. cervical mucous and nasal glands. Human milk Bovine LF and human LF have approximately Processes and capacities does not appear to contain lactoperoxidase 69% of similarities in amino acid residues. (Tenovuo, 1985). However, a more recent study Human milk is the most abundant source of LF. It Market share confirmed the presence of lactoperoxidase in is one of the major whey proteins in human milk human colostrum. with concentrations of 1.4–2.0 mg mL-1 but only Company description a minor component in bovine milk with only one In milk, lactoperoxidase is one of the non tenth (0.1–0.2 mg mL-1) of concentration found immunoglobulin protective proteins and its R E S E A R C H in human milk. antibacterial activity in raw milk was suggested Lactoperoxidase is a hemoprotein that as early as 1924. catalyzes the oxidation of thyocyanate and iodide New researches and Bovine milk contains about 20 times higher LP ions in the presence of hydrogen peroxide to developments than that of human milk (Gothefors and produce highly reactive oxidizing agents. These Marklund 1975) and it is the second most products have a broad spectrum of antimicrobial abundant enzyme (De Wit and Van Hooydonk New applications effects. They can kill viruses, gram positive and 1996) in bovine milk. gram negative bacteria, fungi, and probably also mycoplasmas and parasites.
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET O B J E C T I V E S Immunoglobulin M A R K E T Alpha-Lactalbumine Industrial users needs, Beta - Lactalglobuline expectations and volumes Bovine Serum Water Whey Protein Applications in segments Albumin Concentrate and consumption trends Lactoferrin Minerals Consumer market trends by Whey Protein Lactoperoxidase Whey food segments Isolate Milk Peptides Prospective and forecast Lactose Delactosed & Demineralized M A N U F A T U R E R S whey Proteins Processes and capacities Phosphocaseinates Market share Rennet Casein Company description Caseins R E S E A R C H Ionic Casein Caseinates New researches and developments Lactic Casein New applications
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET Lactoperoxidase could elicit with bacteriostatic FUNCTIONALITIES and/or bactericidal activity on a variety of O B J E C T I V E S susceptible microorganisms including bacteria, In many ways, lactoferrin has been an easy fungi and viruses. The molecular mechanism (s) protein to investigate; however, there have been M A R K E T of such inhibitory effects depend on the type of difficulties understanding specific electron donor, test media, temperature and pH structure/function relationships, particularly as it and could range from oxidative killing to functions in vivo; Industrial users needs, blockage of glycolytic pathways or interference Heat stability: At low ionic strength and/or low expectations and volumes in cytopathic effects; pH, the resistance of lactoferrin to heat Antibacterial Effect: Gram-negative, catalase- denaturation is good and methods for heats Applications in segments positive organisms, such as pseudomonas, treatment and pasteurization have been and consumption trends coliforms, salmonellae and shigellae, are not published. only inhibited by the lactoperoxidase system Iron bioavailability: Two features of the (LPS) but also, depending on the medium Consumer market trends by functional properties of lactoferrin are its ability conditions (pH, temperature, incubation time, food segments to bind iron exceptionally tightly and the coupling and cell density) may be killed. Gram-positive, of rigid-body domain movements to iron bindings catalase negative bacteria, such as streptococci Prospective and forecast and release. and lactobacilli are generally inhibited but not Anticarcinogenic effect: Lactoferrin has been killed by the LPS. M A N U F A T U R E R S reported to inhibit cancer growth by inducing Antifungal Effect: Seifu et al . declared that LPS apoptosis and stimulating the production of in goat milk inhibit growth and proliferation of critical cytokines, such as IL-18 etc. many fungal species viz., Aspergillus flavus , Processes and capacities Antimicrobial agent: Its capacity to bind iron Penicillium chrysogenum, Trichoderma spp., and to stay bound with iron until pH 3 interfer in Alternaria spp. and Claviceps spp., Corynespora the proliferation of pathogen bacteria. Market share cassicola , Phytophthora meadii and Corticium Antiviral agent: Recently, Antiviral activity has salmonicolor; however, Candida albicans and been described as well for herpes, cytomegalo Company description Pythium spp. were not affected by the this and influenzes virus. system. Inflammatory and Immune response: Antiviral Effect: Shin et al . reported the R E S E A R C H Lactoferrin has various effects on the immune potential of oral administration of LPS to system, such as regulation of antibody attenuate pneumonia in influenza-virus-infected production, complement activation, and natural New researches and mice through the suppression of infiltration of killer cell function. developments inflammatory cells in the lung. Anti-oxidant effect: Lactoferrin scavenges Lactoperoxidase can be combined to � excess iron thereby protects the host to New applications lactoferrin in protection of the mucosal surface peroxidation reactions. and prevention of tooth decays.
THE WORLD LACTOFERRIN AND LACTOPEROXIDASE MARKET APPLICATION RANGE O B J E C T I V E S Based on the physiological, biological and Some of the applications are related to the functional properties attributed to lactoferrin natural presence of lactoferrin and M A R K E T and lactoperoxidase, there are a number of lactoperoxidase in the human secretions: milk, interesting and innovative possibilities for saliva, tears. the application of these bio-active proteins The following table will describe the potential Industrial users needs, extracted from bovine milk. applications of lactoferrin and lactoperoxidase. expectations and volumes Functionality Food Infant Sports and Pharmaceuticals Veterinary and Personal care Applications in segments products formula functional food feed products and consumption trends specialties Consumer market trends by food segments � Iron absorption � � � Prospective and forecast Anti- � � � inflammatory M A N U F A T U R E R S Lactoferrin Intestinal flora � � � � � protection Processes and capacities Antibacterial � � � Immune cell Market share � � � � stimulation Company description Antioxidant � � � Lactoperoxidase Antimicrobial R E S E A R C H � � � Anti- � � inflammatory New researches and in guts developments Intestinal flora � � � � New applications protection
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