The eI4Africa EU/FP7 Project Exploiting e-Infrastructures potential - PowerPoint PPT Presentation

The eI4Africa EU/FP7 Project Exploiting e-Infrastructures potential to boost RTDI in Africa info@ei4africa.eu www.ei4africa.eu

African Pharmacological Science Gateway Jaran Eriksen| Karolinska 13/11/2013- 2 Institutet|eI4Africa

Background/Rationale ■ Previous North-South Scientific and Technology transfer drive has not achieved the technology transfer hoped for  trained African scientists failing to continue their work upon returning to their home institutions ■ Challenges: ■ brain drain from Africa ■ lack of scientific development ■ A few successful groups set up competence in key research areas important for drug discovery, development and rational use of medicines ■ Remain scientifically isolated with minimal possibilities for South-South interaction to build on the knowledge and technical skills they have individually established ■  Need for strengthened S-S collaboration in this field Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 3

African Pharmacological Science Gateway Objectives ■ Design, develop, test, implement and evaluate a concept for cost- effective virtual e-infrastructure collaboration for African medical sciences focusing on the needs of pharmacological sciences and clinical trials for improving African healthcare: ■ Genomics and bioinformatics ■ Pharmacokinetics/pharmacometrics ■ Bioanalysis, drug analysis and metabolism ■ Clinical trial sciences ■ Areas important in drug development and rational use of medicines  should be carried out in collaboration across countries ■ All tools and collaborative platforms for this knowledge sharing should be available at the Africa Grid Science Gateway ( http://sgw.africa-grid.org/) as a pharmacological gateway Jaran Eriksen|Karolinska Institutet eI4Africa 13/11/2013 - 4

Strengthening capacity and capability for drug development and rational use of medicines in Africa ■ Ensuring continued laboratory based pharmacological research in Africa by enabling access to tools for analyzing and calculating data, and to expertise in these areas  reduce brain drain and unnecessary visits to US/Europe ■ Continued contact, mentorship and access to necessary tools ■ Strong capacity to maintain contacts between African laboratory based pharmacological scientists  stimulate establishment of strong clinical pharmacological research in African countries Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 5

Properties of shared tools ■ Tools simplifying collaboration across institutions within and outside Africa for basic and clinical drug research ■ The virtual collaborative community should build on easily accessible tools that interested partners can gain access to ■ Open access tools and solutions ■ Establishment of technical competence for maintenance and development Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 6

Proposed members of the e- pharmacological sciences community to participate in the Africa Grid Science Gateway project AiBST (African Institute of Biomedical Science & T echnology www.aibst.com, Zimbabwe , Collen Masimirembwa Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013 - 7

Potential resources at the gateway Tools for ■ Genomics and bioinformatics ■ Pharmacokinetics/pharmacometrics ■ Bioanalysis, drug analysis and metabolism ■ Clinical trial sciences ■ Electronic library of publications and basic software packages such as statistics ■ Platform for multimedia contacts and e-learning tools Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 8

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Resources at the gateway Tools for ■ Genomics and bioinformatics:  ClustalW ( www.ebi.ac.uk/Tools/phylogeny/clustalw2_phylogeny/ ) G-HMMER ( sgw.africa-grid.org/g-hmmer )  GROMACS ( sgw.africa-grid.org/gromacs )   BLAST ( blast.ncbi.nlm.nih.gov/ ) The Human Cytochrome P450 ( CYP ) Allele Nomenclature Database  (www.cypalleles.ki.se/) ■ Pharmacokinetics/pharmacometrics: ■ Share information on laboratory analysis – send samples for analysis (e.g. MUHAS and Makerere) Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 10

Resources at the gateway II Tools for ■ Bioanalysis, drug analysis and metabolism: ■ http://www.uppsala-pharmacometrics.com/software. html including Nonmem for sparse pharmacokinetic/dynamic analyses available at http://psn.sourceforge.net/ ■ Xpose application for Nonmem at http://xpose.sourceforge.net ■ Population Experimantal Design at http://poped.sourceforge.net/ ■ onolix, software for pharmacometric work: www.lixoft.com ■ http://www.summitpk.com/tools/tools.htm ■ Clinical trial sciences: ■ The website clinicaltrials.gov (US governmental website over registered clinical trials) ■ The toolkit for writing clinical trial protocol www.ct-toolkit.ac.uk/rotuempa/protocol-development ■ SPIRIT 2013- Standard Protocol Items (presented at annals.org/ article.aspx? articleid= 1556168 and explained at www.bmj.com/content/346/bmj.e7586.pdf%2Bhtml Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 11

Resources at the gateway III ■ Electronic library of publications and basic software packages such as statistics ■ Platform for multimedia contacts and e-learning tools Jaran Eriksen| Karolinska Institutet|eI4Africa 13/11/2013- 12

Drug MANAGEMENT APPLICATION (DMA) Jaran Eriksen| Karolinska 13/11/2013- 13 Institutet|eI4Africa

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