The diagnosis of leprosy Introduction Salvatore Noto, Pieter A M - PowerPoint PPT Presentation

The diagnosis of leprosy Introduction Salvatore Noto, Pieter A M Schreuder and Bernard Naafs, Leprosy mailing list, October 2011 ��

Definition of leprosy Leprosy is a chronic infectious disease caused by M. leprae . It affects mainly the skin and the peripheral nerves . ��

“Protean diseases” ��

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Courtesy of S. Noto ��

Courtesy of S. Noto Leprosy (BT) ��

Leprosy (BL) �� Courtesy of S. Noto � ��

Leprosy, BL reactive after pregnancy Courtesy of B Naafs ��

Leprosy (borderline in reversal reaction) Courtesy of S. Noto ��

Courtesy of S. Noto Leprosy (LL) ��

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Leprosy (LL) Courtesy of S. Noto ��

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Leprosy in families: father and child Courtesy of J A da Costa Nery ��

Key concepts in clinical leprosy - The 3 cardinal signs of leprosy; - Ridley and Jopling classification; - Reactions and nerve damage. ��

The 3 cardinal signs of leprosy 1. Skin patch with loss of sensation; 2. enlarged peripheral nerve; 3. positive slit-skin smear. ��

The leprosy spectrum according to the Ridley and Jopling classification � �� % � � � �� &'��(' ('� )' *'��+' �,'�&'� BT = borderline tuberculoid leprosy BB = mid borderline leprosy BL = borderrline lepromatous leprosy BI = bacteriological index - - = negative + = degree of positivity ��

Nerve damage in leprosy 1. dermal nerves; 2. cutaneous nerves; 3. major nerve trunks. Source: B Naafs (1994) in E Nunzi, D Leiker, “Manuale di leprologia” ��

Nerve damage in leprosy Most of the nerve damage in leprosy takes place during acute exacerbations of the disease called “Reactions”. ��

How to diagnose leprosy • history taking; • physical assessment; and • laboratory investigations. ��

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The diagnosis of leprosy Introduction Salvatore Noto, Pieter A M - PowerPoint PPT Presentation

The diagnosis of leprosy Introduction Salvatore Noto, Pieter A M Schreuder and Bernard Naafs, Leprosy mailing list, October 2011

The Diagnosis of Leprosy - Part II. The 2 nd cardinal signs of leprosy Salvatore Noto, Pieter A M

Diagnosis of leprosy - Part II. The 1 st cardinal signs of leprosy Salvatore Noto, Pieter A M

Diagnosis and the clinical spectrum of leprosy Salvatore Noto, Pieter A. Schreuder and Bernard

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