Spatial Analysis 3D —Software tools for point pattern analysis in the nervous system (and beyond) Benjamin Reese Neuroscience Research Institute and Department of Psychology University of California at Santa Barbara
The mature retina contains multiple types of nerve cells positioned in distinct cellular layers: photoreceptors interneurons ganglion cells
Events that transform the immature neuroepithelium into a differentiated retina: Fate determination Migration Process outgrowth and target recognition Synaptogenesis Cell death →
from Dorsky et al., 1997 from Wikler and Rakic, 1994
Fate determination Cell death Dispersion
Random Real
Random Real
Strain-specific effective radius Low Density High Density Strain-invariant effective radius Low Density High Density
B6 A
B6 100 µm A 0
d min simulation Random simulation Cholinergic amacrine cells
Challenges for 3D Analysis
Challenges for 3D Analysis • Computation
Challenges for 3D Analysis • Computation
Challenges for 3D Analysis • Computation • Visualization
Acknowledgements Mary Raven—UCSB Dan Lofgreen—Channel Islands Consulting Stephen Eglen—Cambridge University Funded by the NIH: National Institute of Mental Health National Eye Institute
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