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264 Letters to the Editor men and pelvis are essential to stage the disease accurately P. Lymphoma of the parotid gland. Laryngoscope 1993;103: [12]. Currently, there is a controversy in the reported liter- 17-21. ature regarding the accuracy


  1. 264 Letters to the Editor men and pelvis are essential to stage the disease accurately P. Lymphoma of the parotid gland. Laryngoscope 1993;103: [12]. Currently, there is a controversy in the reported liter- 17-21. ature regarding the accuracy of positron-emission tomog- 5. Ciccone E, Truini M, Grossi CE. Lymphoid complement of the raphy-CT scanning of MALTomas. human salivary glands: function and pathology. Eur J Morphol Radical parotidectomy is not indicated because of the 1998;36(Suppl):252-6. associated morbidity, and because RT alone can secure local 6. Diss TC, Wotherspoon AC, Speight P, Pan L, Isaacson PG. B-cell control and allow tissue preservation. Low dose RT (30 monoclonality, Epstein Barr virus, and t(14;18) in myoepithelial Gy) is extremely efficacious for local control of the disease, sialadenitis and low-grade B-cell MALT lymphoma of the paro- with local control rates ranging from 97% to 100%; 5-year tid gland. Am J Surg Pathol 1995;19:531-6. progression free survival and overall survival are approx- 7. Marioni G, Marchese-Ragona R, Marino F, et al. MALT-type imately 76% and 91%, respectively [13]. lymphoma and Warthin's tumour presenting in the same parotid Regional and distant relapses are not common in gastric gland. Acta Otolaryngol 2004;124:318-23. MALT lymphomas, but extragastric MALTomas tend to be 8. Rosenstiel DB, Carroll WR, Listinsky CM. MALT lymphoma pre- more aggressive and may recur in the regional or distant senting as a cystic salivary gland mass. Head Neck 2001;23:254-8. lymph nodes and in other organs [14, 15]. According to 9. Anacak Y, Miller RC, Constantinou N, et al. Primary muco- Wenzel et al ., patients with MALToma of the head and sa-associated lymphoid tissue lymphoma of the salivary glands: neck are at a relatively high risk for early dissemination a multicenter Rare Cancer Network study. Int J Radiat Oncol Biol and subsequent distant recurrence when only local therapies Phys 2012;82:315-20. are applied. In the current case, there was no lymph node 10. Ferri C, Caracciolo F, Zignego AL, et al. Hepatitis C virus infection or other organ involvement. in patients with non-Hodgkin's lymphoma. Br J Haematol Due to the high local control rate and low morbidity, 1994;88:392-4. together with the indolent biology of the disease, we con- 11. Ando M, Matsuzaki M, Murofushi T. Mucosa-associated lym- clude that moderate-dose RT (25 to 30 Gy) is a safe and phoid tissue lymphoma presented as diffuse swelling of the paro- effectivetreatment option for stage I and II MALTomas in tid gland. Am J Otolaryngol 2005;26:285-8. the parotid gland. 12. Perry C, Herishanu Y, Metzer U, et al. Diagnostic accuracy of PET/CT in patients with extranodal marginal zone MALT lra 1 , Pamela Alic ngsley 1 , Pr eety Negi 1 , Ba Babusha K Kalr Pamela Alice K e Kingsley , Preety Negi , lymphoma. Eur J Haematol 2007;79:205-9. John 2 , K atra 3 , U George 4 M Jo Josep seph Jo Kanward ardeep eep K Kwatra , Utta ttam B Braino G 13. Tsai HK, Li S, Ng AK, Silver B, Stevenson MA, Mauch PM. Role of radiation therapy in the treatment of stage I/II mucosa-asso- Departments of 1 Radiotherapy, 2 Clinical Hematology and ciated lymphoid tissue lymphoma. Ann Oncol 2007;18:672-8. Hemat Oncology, 3 Pathology, 4 Radiology, Christian Medical 14. Wenzel C, Fiebiger W, Dieckmann K, Formanek M, Chott A, College and Hospital, Ludhiana, India Raderer M. Extranodal marginal zone B-cell lymphoma of muco- sa-associated lymphoid tissue of the head and neck area: high rate Correspondence to: Cor espondence to: Babusha Kalra Babusha Kalra of disease recurrence following local therapy. Cancer 2003;97: Department of Radiotherapy, Christian Medical College 2236-41. and Hospital, Brown Road, Ludhiana, 15. Zinzani PL, Magagnoli M, Ascani S, et al. Nongastrointestinal Punjab 141008, India mucosa-associated lymphoid tissue (MALT) lymphomas: clinical E-mail: kalrababusha@gmail.com and therapeutic features of 24 localized patients. Ann Oncol Received on Jan. 7, 2015; Revised on Oct. 26, 2015; Accepted on Nov. 5, 2015 1997;8:883-6. http://dx.doi.org/10.5045/br.2015.50.4.262 AuthorsÊ Disclosur AuthorsÊ Disclosures s of P of Pote tent ntia ial Confl l Conflicts of Inter ts of Interest st Sickle cell-  thalassemia with Sickle cell- thalassemia with No potential conflicts of interest relevant to this article concom ncomitant hem itant hemophilia A: philia A: a rar a rare were reported. presentation pr esentation REFERENCES REFERENCES 1. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the E EDITOR: Sickle cell-  thalassemia (HbS-  tha- TO TH THE EDI International Lymphoma Study Group. Blood 1994;84:1361-92. lassemia) is a sickling disorder of red blood cells in varying 2. Thieblemont C, Berger F, Dumontet C, et al. Mucosa-associated severity, which results from compound heterozygosity for lymphoid tissue lymphoma is a disseminated disease in one third sickle cell trait and  thalassemia trait. In India, the fre- of 158 patients analyzed. Blood 2000;95:802-6. quency of the  S gene reaches as high as 40%, particularly 3. Balm AJ, Delaere P, Hilgers FJ, Somers R, Van Heerde P. Primary in the tribal groups, whereas the incidence of the  thalasse- lymphoma of mucosa associated lymphoid tissue (MALT) in the mia gene is around 3 – 4% in the general population [1]. parotid gland. Clin Otolaryngol Allied Sci 1993;18:528-32. Hence, the occurrence of HbS-  thalassemia due to in- 4. Mehle ME, Kraus DH, Wood BG, Tubbs R, Tucker HM, Lavertu ood Res 2015;50:254-67. Blood Res Bl bloodr bloo dresear esearch.or h.or.kr .kr

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