Oral presentation at MIE 2011 Service Oriented Data Integration for a Biomedical Research Network Matthias Ganzinger a, , Tino Noack a , Sven Diederichs b,c , Thomas Longerich c , Petra Knaup a a Department of Medical Informatics, University of Heidelberg, Heidelberg, Germany b Helmholtz-University-Group “Molecular RNA Biology & Cancer”, German Cancer Research Center (DKFZ), Heidelberg, Germany c Institute of Pathology, University of Heidelberg, Heidelberg, Germany. Corresponding Author: Matthias Ganzinger, Dpt. of Medical Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany; E-mail: matthias.ganzinger@med.uni-heidelberg.de Matthias Ganzinger Oslo, August 30, 2011
Overview project TRR77 • Research network Transregio 77: „Liver Cancer. From molecular pathogenesis to targeted therapies.” • 22 projects – From chronic liver disease to tumor formation – Basic molecular mechanisms / novel targets – Novel approaches to therapy • TRR 77 is funded by German Research Foundation (DFG) MIE 2011 Matthias Ganzinger 2
Project locations MIE 2011 Matthias Ganzinger 3
Overview TRR 77 • Goal: Availability of data for cross-project analysis • Types of data: – tissue – molecular – genomic – clinical MIE 2011 Matthias Ganzinger 4
Challenges • Local data storage and evaluation, e.g. Excel files • Heterogeneous data structures • Data ownership and access control • User interface for scientists MIE 2011 Matthias Ganzinger 5
Cross project data integration Common user interface Cross project query layer Access control Access control Access control Access control Access control Project Project Project Project Project Projects keep control over data MIE 2011 Matthias Ganzinger 6
Data service and directory Publish to directory Technical description service of the service interface (WSDL) Metadata Service Vocabulary Use of Semantic Terminology standardised descripton of Directory Harmonisation vocabulary the service Service Committee MIE 2011 Matthias Ganzinger 7
pelican p latform e nhancing li ver ca ncer n etworked research ? Data Service Vocabulary Metadata Analytical Service Directory Service Process ? ! Process Chain P 1 P 2 P n Cross TRR pelican is based on caBIG MIE 2011 Matthias Ganzinger 8 https://cabig.nci.nih.gov
Discussion • Integrated vs. federated data storage • Data services are generated by caCORE • caBIG considered as SOA construction kit with biomedical context • Some tools are hard to handle (caDSR) MIE 2011 Matthias Ganzinger 9
Future research • Collect metadata • Improve user interface • Intellectual capital concerns • Add more analytical and data services MIE 2011 Matthias Ganzinger 10
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