RSDL General Technical Presentation Presented by: Larry Sproat - PowerPoint PPT Presentation

RSDL – General Technical Presentation Presented by: Larry Sproat

RSDL - General Technical Presentation (2)

This amount of VX is enough to Kill a normal 77 kg man RSDL - General Technical Presentation (3)

RSDL – The Product  Liquid skin decontaminant that removes or neutralizes all known traditional CW agents:  GA(Tabun), GB(Sarin), GD(Soman, and GF(Cyclohexyl Sarin)  VX, and VR(Nerve Agent)  HD(Mustard)  T2-Toxin RSDL - General Technical Presentation (4)

Reactive Skin Decontamination Lotion (RSDL)  Selected as Increment 1, Dec 2004  Approved by FDA as 510(k) predicate device  Milestone C approved 23 Mar 07  Used by US DoD and Major NATO Military agencies  Tested as Effective in Decontaminating or Removing all CW Agents in less than 2 minutes  Approved as safe to use on the Skin by the US FDA, European Union CE Mark, and Australian TGA RSDL - General Technical Presentation (5)

RSDL – The Product  Only product on the market with clearance as a Medical Device from all three Regulatory Bodies: FDA, EU (MHRA) and Australian TGA.  Clearance supported by complete Efficacy, Safety, and Toxicity studies  Active ingredient is potassium 2,3-butanedione monoximate (KBDO).  Decontamination is achieved through removal, hydrolysis and nucleophilic displacement.  Removal is enhanced by the scrubbing action of the foam applicator. RSDL - General Technical Presentation (6)

List of Test Facilities  Domestic (USA) independent laboratories and Government entities:  Battelle Memorial Institute of Research  Hill Top Research Inc.  Southern Research Institute  US Army Edgewood Chemical and Biological Center (ECBC)  US Army Medical Research Institute of Chemical Defense (USAMRICD)  US Department of Energy – Lawrence Livermore National Laboratory  Walter Reed Army Institute of Research, USA Medical Research Institute of Chemical Defense  International test facilities (list includes but not limited to):  Canadian Department of National Defence: Defence Research and Development Canada – Suffield (DRDC-S)  TNO Prins Maurits Laboratory; Defense Chemical Biological Laboratory; The Netherlands  FOI Defense Chemical Biological Laboratory; Sweden  Forsvarets Forsknings Instiyutt (FFI); Norwegian Defence Research Establishment; Division for Protection (V)  Defence Science and Technology (DSTA); Singapore RSDL - General Technical Presentation (7)

Product History RSDL is Licensed to RSDL is down- RSDL O’Dell selected as the EZEM Inc. obtains CE Canadian Engineering replacement purchases US DoD Mark and Department who teams up for M291 by US RSDL places its TGA of Defence with EZEM Inc. DoD (Foreign License first full rate clearance Develops from O’Dell for GMP Comparative production as Medical RSDL Testing – FCT) manufacturing Engineering contract Device 1980 - 1995 1991 - 1992 1997 1998 - 1999 2001 2003 2005 2007 2008 RSDL RSDL is RSDL RSDL is BRACCO deployed fielded in obtains FDA approved for Imaging with Canada and clearance as procurement acquires Canadian some other a Medical by the US EZEM Inc. troops to EU countries Device DoD Gulf war RSDL - General Technical Presentation (8)

Customers  United States  France  Canada  Australia  Belgium  Germany  The Netherlands  Spain  Slovenia  Ireland  Greece  Sweden  UK NBC Team  OPCW RSDL - General Technical Presentation (9)

Countries Using RSDL (Cont)  Austria  India  Czech Republic  Israel  Denmark  Italy  Dubai UAE  Japan  Estonia  Jordan  Finland  Kazakhstan  Hong Kong  New Zealand  Hungary  Norway RSDL - General Technical Presentation (10)

Countries Using RSDL (Cont)  Portugal  Saudi Arabia  Singapore  Slovakia  South Korea  Switzerland  Taiwan  United Kingdom  USA RSDL - General Technical Presentation (11)

RSDL vs. Powders (1) RSDL Powders RSDL - General Technical Presentation (12)

RSDL vs. Powders (2) RSDL Powders   Dissolves CA agents from skin into Absorptive particles can become a solution where neutralization can respiratory threat. occur. No re-aerosolization.  Following a US DoD FCT study, M291  Lotion does not off-gas in the presence was shown to off-gas CW agent 24 hours following animal sacrifice – As of moisture or water vapor. evaluated by Battelle Memorial  Lotion does not compromise respirator Institute. seal – Evaluation done by DRDC -  Suffield. Powders are likely to compromise respirator seal.  Tactile sensation allows completeness  of coverage to be felt. Difficulty assessing complete coverage. RSDL - General Technical Presentation (13)

Objective • Compare the efficacy of skin decontamination products recommended by doctrine against challenge by nerve agents • Decons evaluated – RSDL – M291 SDK – 1% soapy water – 0.5% bleach USAMRICD

Conclusion of USAMRICD Study RSDL - General Technical Presentation (15)

In reviewing the test, RSDL offers superior protection against all forms of CW Agents, and even if applied 30+ minutes after exposure can tremendously reduce casualties. Users should also be aware that it takes two packets of M291 to cover the same amount of skin as one packet of RSDL RSDL - General Technical Presentation (16)

RSDL’s Benefits  Thorough decontamination.  Non-toxic residue – removed with water or soap and water when operational conditions permit.  Logistically easy to manage.  Ease of use for immediate self decontamination.  Field proven – deployed in both Gulf wars with no Adverse Events reported.  Inexpensive Training Lotion available. RSDL - General Technical Presentation (17)

Application 1. Identify/Suspect contamination RSDL - General Technical Presentation (18)

Application 2. Open packet RSDL - General Technical Presentation (19)

Application 3. Wipe exposed skin with applicator RSDL - General Technical Presentation (20)

Application 4. Rinse when conditions permit RSDL - General Technical Presentation (21)

Conclusions • RSDL provides superior protection against GD, GF, VX, and VR compared to other decons tested • M291 SDK is the least effective – M291 provided no protection against VX and VR – M291 equivalent to 1% soapy water for GD – Wiping with M291 SDK spreads agent on the skin • 0.5% bleach and 1% soapy water are less effective than RSDL, but still provide good protection • RSDL, 0.5% bleach, and 1% soapy water provide significant protection against VX even when decon is delayed for extended periods of time • The window of decon for GD is 3 min or less •