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Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine - PowerPoint PPT Presentation

Jul 01, 2023 •433 likes •570 views

Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine (1) Seigi Oshima Outline 1. Cancer stem cells (CSCs) 2. Previous studies on CSC-targeting therapy 3. My suggestion on the novel therapy 4. Conclusion Whats a Cancer Stem

  1. Prospect of CSC-targeting Therapy Kyoto Univ. Faculty of Medicine (1) Seigi Oshima

  2. Outline 1. Cancer stem cells (CSCs) 2. Previous studies on CSC-targeting therapy 3. My suggestion on the novel therapy 4. Conclusion

  3. What’s a Cancer Stem Cell (CSC)? CSC…. This figure is cited from http://www.childrenshospital.org/gallery/index.cfm?G=67

  4. Normal anticancer drugs target only nCSCs …. nCSC CSC relapse

  5. CSC-targeting Therapy 1. Differentiation therapy 2.CSC niche targeting therapy 3.Direct reprogramming

  6. What’s direct reprogramming?

  7. What’s Direct Reprogramming? differentiation iPS cells Cells you like Somatic cells Cells you like

  8. Previous Studies Yamanaka factors Cancer cells iPS cells

  10. Suggestion • If direct reprogramming can be applied to CSCs, then this method is novel cancer treatment. certain transcription factors Cancer Stem Cells Normal cells

  11. Hurdles toward my suggestion 1. Possibility of developing cancer 2. Extraction of pure CSCs from tumors 3. Drug delivery system

  12. The Future Prospect Victory over Discovery of • CSC Drug CSC-targeting cancer markers Screening drug

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