Presents Th The e Po Powe wer Of S f Syn yner ergy gy For - PowerPoint PPT Presentation

Presents Th The e Po Powe wer Of S f Syn yner ergy gy For or Ac Acti tive e Cur urcu cumi min

Low ow Bio io- av avai aila lability bility Of Co Conv nvent entional ional Tur urme meric ric Extr tract act o Traditional use of turmeric – turmeric powder in culinary applications o Conventional turmeric extracts contain only Curcuminoids o Very low retention in blood

Turmeric, a natural immunity booster that has low bloodstream Story Of The World’s Only absorption 100% Tur urme meri ric c Extr trac act t Curcumin, the active ingredient in turmeric Wi With th Sup uperi erior or Bio io-ac activity tivity Highly bio-absorbable curcumin extract : BCM- 95 8 – 12 hours retention in the bloodstream, proven by research Total 12 patents nts Pending Worldwide - 14 paten ents More than 25 publish lished ed human an clinic nical l studies dies

2 1 2 1 Chemi Ch mical cal Co Comp mposition osition Of Tur urmer meric ic Curcuminoids Volatile oils Curcuminoids 2-6 % Volatile oil 3-7 % Desmethoxy curcumin Turmerones Carbohydrates 60-70 % Bis desmethoxy curcumin Ar-turmerone Moisture 6-13 % Fat 5-10 % Most active Protein 6-8 % ingredient in turmeric, Mineral matter 3-7 % but very poor in oral Fiber 2-7 % bio availability

Enh nhanc ncin ing The he Power er Of Cu Curcu cumin in Thr hrough h Syne nerg rgism ism CURCUM UMIN AR AR-TUR URMERON ONE 100% Turmeric Extract

PO POWE WER R OF OF SYN SYNER ERGY GY FO FOR ACT CTIV IVE E CUR CURCUM CUMIN IN

Oral al Bio ioav availability ailability Human Crossover Study to evaluate BCM – 95 is 6.93 times more Bio- availability of BCM – 95 , Indian bio-available than Curcumin journal of pharmaceutical sciences, July – August 2008, 445 - 449

Mech chanism anism of of e enh nhan ance ced d cu curcu cumi min n bio ioavai availability lability Functio ction n P glycoprotein (Pgp)- an Pumps xenobiotocs out of cells into intestinal lumen • important protein of cell • leads to reduced absorption and low bioavailability membrane , widely Role e of Pgp in curcumin min absorptio ption distributed in intestine Increase the outflow (efflux) of curcumin into intestinal • lumen Hence poor bioavailability • How w does turmer merone one help • Turmerones erones are inhib ibitors itors of Pgp Refere erence nce: : • Prevent the efflux of curcumin back to intestine The Role of Turmerones on Curcumin Transportation and P-Glycoprotein Thereby increase the bioavailability of curcumin in body • Activities in Intestinal Caco-2 Cells, J Conclusion clusion Med Food 15 (3) 2012, 242 – 252 Curcumin is better bioavailable in presence of • turmerones

Syner nergistic istic Effect ct Of Curcumin + Turmerones, Curcu Cu cuminoi minoids ds abolishes inflammation in colon carcinogenesis. Ar Ar Tur urmer merone one Incid idenc nce (%) % Inhibit itio ion n of multipl iplic icit ity y Treat atment nt Adeno noma a Adeno noca carcin rcinoma oma Adeno noma a Adeno noca carcin rcinoma oma At the low dose, Turmerones markedly DMH/DSS 88 88 - - suppressed adenoma multiplicity by 73% DMH/DSS+20 ppm TUR 22 67 73 57 Curcumin at both doses suppressed DMH/DSS+100 ppm TUR 50 100 45 32 adenocarcinoma multiplicity by 63-69% DMH/DSS+1000 ppm CUR 22 50 59 69 Combination of Curcumin and Turmerone DMH/DSS+5000 ppm CUR 50 50 59 63 at both low/high doses abolished tumor DMH/DS DSS+20 +20 ppm ppm TUR & 1000 ppm ppm CUR 0 0 100 100 100 100 formation DMH/DS DSS+10 +100 0 ppm TUR & 5000 ppm CUR 0 0 100 100 100 100 No treatment 0 0 - - DMH : Dimethyl hydrazine; DSS: Detran sulfate sodium Referen ence: ce: Murakami et al, Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. Biofactors. 2013;39(2):221-32.

Syner nergistic istic Effect ct Of Curcuminoids and sesquiterpenoids in turmeric suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. . Curcu Cu cumin minoids oids Results indicated that turmeric extract containing both curcuminoids and sesquiterpenoids was more Ar Tur Ar urmer merone one strongly hypoglycemic than either curcuminoids or sesquiterpenoids. Blood glucose level in KK-Ay mice fed diet alone (Cont) or diet containing curcuminoids (C), Turmerones (T) or combination of C + T Reference: Nishiyama et al, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem. 2005; 53 (4): 959-63.

Salient ent Fea eature ures o Enha hanc nced ed bioavailability and reten ention ion in blood o High bioactivity at lower doses o 100% 100% characterised composition o Safet fety proven by detailed toxicity study o GRAS AS Affirmed o Halal al and Koshe her Certified o GMP Certified o ISO 22000 0 Certified o Conforms to California’s Proposition 65 stringent stand ndar ards ds o Produced using only cl clean an sol olar ar energy

Contd… o Compl plies ies to o BAP and PAH4 limit it as per new EU regulation EC/1933/2015. o Acceptable intake of residual solvents guideline set BY EU where e Class s 3 solven vents s are used which is considered to be Solvents with low toxic ic poten ential. ial. o Regulation (EC) No 396/200 2005 5 of the European Parliament and of the Council of 23 February 2005 on maximum residue levels of pesticides o Regulation (EC) No 1881/200 2006 6 of 19 December 2006 setting maximum levels for certain contaminants such as Heavy Metals (lead, cadmium, mercury, tin) in food ingredients. o Adheres eres to EU regulation on maximum level of Aflatoxins in food ingredients.

Bio io Ava vail ilab ability ility Enh nhan ance ceme ment nt – Oth ther r Bran ands ds Curcu cumin + P Pipe perine o Bloodstream retention for a very short time o Long- term health safety concerns Curcu cumin + P Phos osph phatidy atidyl l Chol oline o Curcumin not detected o Only C glucuronide and sulfate Curcu cumin + S Soy oy Le Leci cith thin o Very low levels detected

Bio io Av Avai aila labil bility ity Enh nhan ance cemen ment t – Oth ther r Bran ands ds Li Liqu quid d Bas ased Curcu cumin Curcu cumin + P Pol olyv yvinyl yl py pyrrol olidon done e (P (PVP) ) o Low levels of curcumin and very high levels of emulsifier o Contains upto 75% PVP - a synthetic o Studies conducted on liquid product and binder allowed only 10% in supplement capsules ( powder) by FDA o Measured only C metabolite Oth thers Nanocu Na curcu cumin o Combination of curcumin with vanillin, sustained release, etc. o No scientific proof, unrealistic claims o Long term health safety concerns

Indic In ications ations Fo For Us Use ALZHEMER’S DISEASE NEUROLOGI UROLOGICA CAL L DISE SEASE SES CANCE CER General ral Dos osag age e DEPRES PRESSIO SION INFLAM LAMMAT ATION ON 500 mg twice daily PULMONARY RY & GIT DIABE ABETES ES DIES ESEAS ASE Benefits efits : o Synergism with modern drugs AUTOIM OIMMUN UNE E o Works as adjuvant DISE SEASE SES o Effective as single agent ARTHRI HRITIS o Reduces side effects

Clinically Documented Indications Depression – o 2 human studies published, 1 ongoing in Australia o Dosage : 500 mg twice daily Rheumatoid arthritis - o 1 human study published, 1 ongoing in India o Dosage : 500 mg twice daily Osteoarthritis - o 1 human study published, 1 human study completed o Dosage : 700 – 1000 mg/day Othe her r scientif ntific ically ally documente mented d areas : Alzheimers disease, Prostate cancer, Sub mucous fibrosis, Leukoplakia, Adjunct to radiotherapy Ongoing oing human n studies dies : 3 studies in US, 1 in EU, 2 in Australia, 1 in India

Produc oduct t Ava vail ilab ability ility Gr Grad ades es o BCM-95 CG : Capsule Grade o BCM-95 SG : Soft Gel Grade o BCM-95 DC : Direct Compressible o BCM-95 : Water Dispersible App pplic lications ations Cand ndy y Capsule ules Soft t Gels Efferv rvescent scent Ready y to drink Tablets ets Tablets ets powder r mix

Spe pecif cifications ications

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Awards ards an and Shortlisted for Most Innovative Ingredient at Nutraingr ingredi edients ents Award, 2015- Europe recogn cognitions itions o BCM- 95 Curcumin was selected as a finalist at the Nutr tra a Ingredi dien ents s Awards s , 2015 ( In association with Vitafoods Europe 2015 & organized by NutraIngredient.com ) under the " Readers’ of the Year " and " Unive versit sity Resear arch ch of the Year " category

Aw Awards ards an and reco cogni gniti tions ons

Maj ajor or Glo loba bal l Cli lien ente tele le

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Trus usted ted by by Bran ands s Wo Worldw ldwide ide

Tha hank nk you ou