(AIM:REDX) Compelling opportunity to take targeted oncology and fibrosis medicines into the clinic Corporate Presentation June 2020
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General Use Disclaimer updated June 2020 Redx Pharma Corporate Presentation - June 2020 2
Redx Pharma Overview Biotech focused on small molecule, targeted medicines in oncology and fibrosis • Targeting compel elling g opp pport rtunities in n di dise sease e area eas with hi high gh unm unmet ne need ed and nd st strong sci cientific rat rationale e • High ghly ex experi rien enced in-house e rese research tea eam with pr prov oven en track rec recor ord bui built on n med edicinal chem chemistry ry ex expertise − 2017 Sale to Loxo Oncology/Eli Lilly of BTK inhibitor (now LOXO-305) for $40M cash; promising Ph 1/2 results − 2019 Sale to Jazz Pharmaceuticals of pan-RAF inhibitor for $3.5M with up to $203M in milestones, plus royalties • In n onc ncol ology gy, RX RXC00 C004 ha has s opp pport rtunity to unl unloc ock po potential of the he Wnt pa pathway in n ge genetically selected pa patients − RXC004 Phase 1 monotherapy dose-escalation study completing in 2020, building on compelling animal efficacy data − Targeted at tumours driven by Wnt pathway in multiple cancers – both monotherapy and immuno-oncology combination − Therapeutic window for class now evident (120+ patients in clinical trials) with early signs of efficacy in targeted patients • In n fibros osis, s, ROC OCK2 is an n ex exci citing target in n mul ultiple e fibrot otic di disea sease ses s with RX RXC0 C007 07 pl planned d to enter er cl clini nic in n 2021 021 − RXC007 as a ROCK2 selective inhibitor was nominated as a preclinical development candidate in H1 2020 − Promising preclinical efficacy and targets significant commercial markets (IPF, NASH, diabetic nephropathy) with limited competition in ROCK2 pathway − ROCK2 inhibitor belumosudil (KD025) by Kadmon is well tolerated in >450 patients in clinical trials, with clinical anti-fibrotic activity in IPF and compelling efficacy in cGvHD demonstrated • Bey eyon ond de delay to ongo going g cl clinical trial due due to CO COVID-19, 9, ther here e is limited impact on n other Red edx pr prog ogramme act ctivities s to-date IPF = Idiopathic Pulmonary Fibrosis; NASH= Non-alcoholic Steatohepatitis; cGvHD HD= chronic Graft versus Host Disease Redx Pharma Corporate Presentation - June 2020 3
Redx Executive Management Team Ambitious Management team in place with strong scientific, clinical and commercial experience June 2014 Lisa Anson, Dr Richard Armer, 2018 Chief Executive Officer Chief Scientific Officer 20-year career at AstraZeneca plc. Significant experience in both small biotech Significant leadership experience and large pharmaceutical companies through including President of AstraZeneca UK, roles in Pfizer, Organon, Ardana, Oxagen & President of the Association of British Lectus Therapeutics. Successful in generating Pharmaceutical Industry and progressing multiple clinical candidates Dr Andrew Saunders, Dr James Mead, Jan Feb 2018 2019 Chief Medical Officer Chief Financial Officer Oncology focus since 1992 both in Finance leadership roles with 16 years at clinical practice and pharmaceutical/ AstraZeneca, including CFO AstraZeneca biotech industry. Including senior roles Netherlands and Investor Relations; at Eli-Lilly and Roche (Rituximab) PhD in molecular biology Redx Pharma Corporate Presentation - June 2020 4
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