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MASTER 2 Research MASTER 2 Research Fragrances & Fine Chemistry Fragrances & Fine Chemistry

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MASTER 2 Research MASTER 2 Research Fragrances & Fine Chemistry Fragrances & Fine Chemistry st Semester 1 st Semester 1 Fragrance Fragrance Analytical Analytical October- -December December October Chemistry chemistry Chemistry chemistry English courses English courses Bibliography Bibliography & Project & Project management management Organic synthesis Organic synthesis

MASTER 2 Research MASTER 2 Research Fragrances & Fine Chemistry Fragrances & Fine Chemistry st Semester 1 st Semester 1 Fragrance Fragrance Analytical Analytical October- -December December October Chemistry chemistry Chemistry chemistry English courses English courses Bibliography Bibliography & Project & Project management management Organic synthesis Organic synthesis nd Semester 2 nd Semester 2 Practical activity January- -June June January

Host laboratories Host laboratories Laboratoire Physique de la Matière Condensée http://www.unice.fr/icn/ http://lpmc.unice.fr/ http://www.unice.fr/icn/ http://lpmc.unice.fr/ http://www.unice.fr/ecomers/ http://www.cepam.cnrs.fr/ http://www.unice.fr/ecomers/ http://www.cepam.cnrs.fr/

http://www.unice.fr/icn/ http://www.unice.fr/icn/ Fragrance chemistry Origin of Life Eco-Friendly Materials and Polymers Bioactive molecules Catalysis & Fine Chemistry Fluorescent Probes Marine Natural Products Bioinspiration Decorporation

Bioactive molecules Synthetic Induce stress in cancer cells RNA Selective targeting of cancer stem cells Natural Proteins

Marine Natural Products � Applications : • Pharmaceutical • Environmental (antifoulings) • Cosmetics

Marine Natural Products Extraction Extraction Isolation Isolation Valorization Valorization � Applications : • Pharmaceutical Metabolome Metabolome Synthesis Synthesis • Environmental (antifoulings) Structural Structural • Cosmetics determination determination

Fluorescent Probes Objective To understand nucleic acid / protein and nucleic acid / nucleic acid assemblies. How ? Synthesis of dedicated fluorescent tools for in vitro studies and cell imaging R 1 ,R 2 = H, aryl Pd-catalyzed & aliphatic monoamination R 1 Br Br N Br 440 nm R 2 [12 examples] 370 nm [air-stable cat. syst.] [practical & gram-scale] O 540 nm [varied-amine tolerance] Acceptor HO Functionalization O Clickable S O R 1 Internal O Bioconjugation O N Labeling R 2 ε ≈ 18,000 M -1 .cm -1 Applications O Ф ≈ up to 38 % O P O

Decorporation

Eco-Friendly Materials and Polymers *Biobased and/or eco-friendly polymers and (nano)composites * Valorization of : - second generation biomass - co-products from industry and bioraffineries * Recycling and circular economy

Eco-Friendly Materials and Polymers

Bioinspiration Inspiration from natural surfaces (Animal and vegetal) Applications for Surface Elaboration :

Bioinspiration Surface characterizations Electropolymerization Chemistry

Catalysis & Fine Chemistry M A + B A B � Sustainable development � Development of selective methods: C-C, C-O, C-N, C-F… � High production, optimization of process Recyclable catalyst Chiral catalyst Water-soluble catalyst

Catalysis & Fine Chemistry

Fragrance chemistry Characterisation of the odorants of natural raw materials : Chemical and Sensorial Analysis of Volatiles O Atlas Cedarwood Violet Mimosa Vetiver Frankincense

Fragrance chemistry Characterisation of pheromones : Chemical Analysis & Behavioral studies Human model : Murine model :

Origin of Life Myrgorodska, Meinert, Meierhenrich et al.: Angew. Chem. Int. Ed. 54 (2015), 1402

MASTER 2 Research MASTER 2 Research Fragrances & Fine Chemistry Fragrances & Fine Chemistry CONTACT : CONTACT : baldovin@unice.fr baldovin@unice.fr