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Issues Translation Efficacy/adverse reactions - PowerPoint PPT Presentation

Oct 01, 2023 •192 likes •242 views

Issues Translation Efficacy/adverse reactions Risk/resilience/outcomes Modification of Mendelian disorder Oligogenic diseases Complex diseases Study design (next session) & Bandwidth of project

  1. Issues • Translation – Efficacy/adverse reactions – Risk/resilience/outcomes – Modification of • “Mendelian disorder” • Oligogenic diseases • Complex diseases • Study design (next session) & Bandwidth of project – Case/control – Incidence

  2. Issues cont. • Genetic architecture – Rare variation • Large sample sizes • Methods still under development • Determine boundaries with test studies – Higher order models • Modifiers, epistasis etc • Systems biology

  3. Issues cont. • Genetic Architecture – Related phenotypes

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