Innovations powered by technology Next Science Limited Investor Presentation August 2019 1 ASX: NXS
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An established research Founded 2012 Multiple FDA and development 90,000 Listed on ASX clearances company specializing in Patients treated April 2019 with multiple and commercializing with XBIO technology Market cap ~$500m international biofilm solutions regulatory approvals pending 90% of Bacteria exist in biofilm structures posing a threat to human health and the environment XBIO is the only non- Extensive pipeline toxic solution: It YoY Revenue tripled across Medical 19 Patents deconstructs the Established Devices, OTC Drugs >50 Patent Biofilm and destroys global distribution and emerging Pharma applications the bacteria and agreements opportunities reduces the opportunity for the biofilm to form again Investor Presentation – August 2019 3
Corporate Overview Stock Overview Escrowed Securities ASX code NXS Shares escrowed until 25 September 2019 0.07m Share Price (Aug 20, 2019) $2.86 Shares escrowed until 18 April 2020 39.82m Market capitalisation @ $2.86 $512M Shares escrowed until 18 April 2021 72.85m Total Shares on Issue 179.2m Total Shares Escrowed 112.7m Listed Shares (tradable) 66.5m Options escrowed until 18 April 2021 5.85m Escrowed Shares 112.7m Options 10.4m Shareholders (1,555 at listing) 4,547 Average daily volume (since listing) 869,000 Shares Substantial Shareholders Auckland Trust Company Ltd* 25.96% Walker Group Holdings Pty Ltd* 16.16% Matthew Myntti (Founder & CTO) 11.53% Judith Mitchell (Managing Director) 2.64% Total Board & Management Shareholdings 15.4% * Entities related to Lang Walker including disclosed purchases Investor Presentation – August 2019 4
Biofilm is a global healthcare problem 10% Bacteria in BIOFILMS can become up to OF BACTERIA ARE 1000-fold more PLANKTONIC/ resistant to antibiotics FREE-FLOATING and biocides when compared to planktonic counterparts. 90% OF BACTERIA US National Institute EXISTS IN BIOFILM for Health (2002) AMR STRUCTURES Initiative “in humans 80% of infections reside in a biofilm” Investor Presentation – August 2019 5
Biofilms pose a far-reaching threat to humans, animals and the environment DEVICE-RELATED INFECTIONS TISSUE INFECTIONS 11 1 Ventricular derivations Acne 1) 11) 2 12 Contact lens Chronic otitis media, chronic 2) 12) Products developed 3 sinusitis and/or available 3) Mouthwash 13 4 13) Chronic tonsillitis, dental plaque, Endotracheal tubes 4) chronic laryngitis 14 5 In development 5) Vascular central catheters 14) Endocarditis 15 Tissue fillers, breast implants 6 6) Lung infection in cystic fibrosis 15) 7) Peripheral vascular catheters Kidney stones 16) Active Research 16 7 Underway Prosthetic cardiac valves, 8) Biliary tract infection 17) 17 pacemakers and vascular grafts Urinary tract infection 18) No research at this time 8 18 Urinary catheters Vaginosis 9) 19) 19 9 Orthopedic implants and Osteomyelitis 10) 20) 20 prosthetic joints Surgical site infections 21) 10 21 Chronic wounds 22) 22 6
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