Introduction to Drugs 1 University of Hawai‘i Hilo Pre -Nursing Program NURS 203 – General Pharmacology Danita Narciso Pharm D
Learning objectives 2 Understand and differentiate between a broad definition of a drug and a medical definition Understand the advantages of drugs created from natural sources and drugs synthesized in the lab Know the characteristics of the clinical trial phases Know the characteristics of the perfect drug Know the advantages and disadvantages of each dosage form discussed
3 What is a drug? Substances that act on biological systems at the chemical level and alter their Is this a drug? function. Tylenol
4 What is a drug? Substances that act on biological systems at the chemical level Is this a drug? and alter their Tylenol function. Yes
5 What is a drug? Substances that act on biological systems at the chemical level Is this a drug? and alter their Tylenol function. Yes Alcohol
6 What is a drug? Substances that act on biological systems Is this a drug? at the chemical level Tylenol and alter their Yes function. Alcohol Yes
7 What is a drug? Substances that act on biological systems Is this a drug? at the chemical level Tylenol and alter their Yes function. Alcohol Yes Grapefruit juice
8 What is a drug? Substances that act Is this a drug? on biological systems Tylenol at the chemical level Yes and alter their Alcohol function. Yes Grapefruit juice Yes
What is a drug? 9 Medical definition Substances used in the diagnosis, treatment, or prevention of disease in humans or animals. Tylenol? Alcohol? Grapefruit juice?
What is a drug? 10
What is a drug? 11
What is a drug? 12 Dosage Drug Form
Where do drugs come from? 13 Synthetic sources Natural sources Plants Plants (power), nah…. The lab ____________ Animals ____________ Minerals ____________
A new drug is born! 14 No longer guessing Investigational New Drug (IND) application Clinical trials Phase I ___________ Phase II ___________ Phase III ___________ Phase IV ____________ Expedited approval _____________
The perfect drug 15 Would exert a desirable action Have no side effects – or very few Reach its destination at the right concentration at the right time Not overstay its welcome – remain at its site of action for only for the necessary period of time Leave when the job is done – rapidly and completely
How do drugs attempt to reach 16 perfection? Delivery or dosage forms Oral Intravenous Intramuscular Subcutaneous Buccal and sublingual Inhalation Topical Rectal Transdermal
Oral 17 Swallowed Tablet, capsule, syrups, and suspensions Must get absorbed into the blood stream and delivered to the site of action
Intravenous 18 Straight into the vasculature Injectable – arteries and veins Absorption not necessary
Intramuscular 19 Into the muscle Many vaccinations Not 100% bioavailable, faster absorption than oral
Subcutaneous 20 Fatty layer of the skin Insulin and lovenox Slower absorption than intramuscular but anticoagulants ok
Buccal and sublingual 21 Absorbed through mucosal tissue and under the tongue Nicotine gum and Zofran ODT Avoids metabolism, can be absorbed fast or slow
Inhalation 22 Into the lung tissue Inhaler devices and nebulizers Closest to target tissues, coordination issues
Topical 23 Not just for the skin – eye, ear, nose, throat, airway, vagina Lozenges, drops, sprays, creams, and ointments Local effects, absorption varies
Rectal 24 Suppository Antiemetics, antipyretics, & antiepileptics Some first pass effect, helpful for those who cannot swallow
Transdermal 25 To the skin Fentanyl patch, nicotine patch, & Vivelle dot For SYSTEMIC effects
Questions 26 Please email me if you have any questions!
Recommend
More recommend