University College London Hospitals NIHR Biomedical Research Centre Improving ¡Pa-ent ¡Outcomes ¡with ¡Research: ¡ The ¡Appliance ¡of ¡Science ¡ NIHR ¡ UCL ¡Hospitals ¡Biomedical ¡Research ¡Centre ¡ ¡ Bryan Williams MD FRCP FESC FAHA Professor of Medicine and BRC Director 29/08/2013
University College London Hospitals NIHR Biomedical Research Centre “Creating Health and Wealth … ” Unique World Innovation Improved Class and Patient NHS Universities Enterprise Outcomes National Institute for Health Research (NIHR)
University College London Hospitals NIHR Biomedical Research Centre Challenges in the Biomedical Research Pipeline o Cultural change in o Regulatory Challenges Universities o Skills Shortage o Embracing and o Lack of Co-ordinated infrastructure Rewarding Enterprise o Need for Genomics at scale o Need to Leverage Clinical Data o Need for open industrial partnership
University College London Hospitals NIHR Biomedical Research Centre Drug Development at Risk – Need for a New Model for Partnership with Industry Pharmaceutical Industry R&D Productivity
University College London Hospitals NIHR Biomedical Research Centre Discovery, Translation, Innovation, Enterprise NIHR Comprehensive Research Network NIHR Academic Biomedical Health Science Research Centres and Centres Networks BRC University Patient and BioInformatics Discovery Science Genomics Target Validation Phenome Centre
University College London Hospitals NIHR Biomedical Research Centre Biomedical Research Centres • Major Research Infrastructure investment (£100m over 5 years); • Partnership between University biomedical Science and the NHS; • Focus on improving the translation of world class fundamental research into clinical care – unleashing the potential of our leading Universities and the NHS; • Focus on reinvigorating the UK bioscience industry by providing the infrastructure to foster partnerships with SMEs and Pharma; • Focus on experimental medicine – early phase – new drugs, new diagnostics and therapeutic innovation for our patients - first; • Seamless transition from early phase research to clinical adoption and diffusion across the NHS via Academic Health Science Partnerships; • National bioresourcing and informatics – genomics, proteomics – real world data linkage – unparalleled world-wide.
University College London Hospitals NIHR Biomedical Research Centre UCL Hospitals NIHR Biomedical Research Centre Focus on Experimental Medicine Education & Capacity Building in Experimental Medicine Infection, Cancer Cardiometabolic Immunity, Neurosciences Inflammation NHS Patients UCL Science
University College London Hospitals NIHR Biomedical Research Centre What is Experimental Medicine ? “Investigation undertaken in humans , relating where appropriate to model systems, to identify mechanisms of pathophysiology or disease , or to demonstrate proof-of-concept evidence of the validity and importance of new discoveries or treatments .” Medical Research Council “ Usually early phase human studies up to phase IIa, but experimental medicine can be mechanistic studies embedded within later phase studies … .”
University College London Hospitals NIHR Biomedical Research Centre Experimental Medicine and the Translational Pathway at UCL Innovation Office Accelerate translation UCLB / TRO / UCL Enterprise First in man Diffusion – evaluation, safety, CTU Implementation / UCL proof of concept, Patient Outcomes UCLP mechanisms BRC UCLP Discovery / Target CRF Adoption – Efficacy Validation R e v e r s e T Industrial Collaboration r a n s l a t i o n Sir Francis Crick Institute Yale – UCL Partnership Cross BRC/BRU Collaboration Creating Health and Wealth MRC Chapter – e Health
University College London Hospitals NIHR Biomedical Research Centre Discovery → Proof of concept UCL Discovery Engine and the Sir Francis Crick Institute BRC and BRUs UCLH-UCL NIHR BRC • Cardiometabolic • Cancer • Infection and Inflammation • Neuroscience GOSH/Child Health NIHR BRC Moorfields/Ophthalmology NIHR BRC UCLH-UCL NIHR BRU Dementia
University College London Hospitals NIHR Biomedical Research Centre Early Phase Clinical Research Facilities Proof of concept / mechanisms • Dedicated CRF • Embedded within the hospital • Complex Phase I/II study capability • New Neuroscience CRF at Queen Sq.
University College London Hospitals NIHR Biomedical Research Centre UCL Partners: Adoption & Translation • Largest Academic Health Science Network in Europe; • Translating, Adopting and Delivering Biomedical Innovation at scale; • Facilitating and Streamlining later phase clinical trials; • Evaluation at scale
University College London Hospitals NIHR Biomedical Research Centre Big Data – leveraging the research potential of our patient populations • UCL FARR Institute is one of four E-Health Informatics Research Centres funded by the MRC and partners. • Aims to bring together its partners’ world-class clinical science, informatics expertise and educational strengths to establish an international centre of excellence in innovative health informatics research , and maximise translational impact for patient benefit. • National Health Informatics Collaborative (NHIC) – Big 5 BRCs (UCL, Imperial, Kings, Oxford, Cambridge) combine to leverage patient data for researcg
University College London Hospitals NIHR Biomedical Research Centre Context for Change … .. • NHS “Innovation for Health and Wealth” Agenda; • Major Government investment in UK Bioscience; • Key emphasis on leverage and wealth creation; • Industrial engagement – Pharma, MedTech, Biotech and SMEs – inward investment • Enterprise and Entrepreneurship from within; • Innovation in Health Care; the “value proposition”
NIHR University College London Hospitals Biomedical Research Centre
University College London Hospitals NIHR Biomedical Research Centre New partnerships … NHS UCL UCLH BRCs
University College London Hospitals NIHR Biomedical Research Centre What does all of this mean for patients? • First and often unique access leading edge developments in medicine; • Recruitment and retention of world-leading clinicians/academics; • A culture of excellence and academic rigor that permeates all that we do; • An opportunity to tackle fundamental challenges in medicine: • Examples: - Treatment Resistant Cancer - Emerging antibiotic resistance / HIV and epidemic viruses - Best exploitation of developments in imaging - Treatments for Dementia - Better treatment for Stroke
University College London Hospitals NIHR Biomedical Research Centre Public and Patient Involvement • We are looking for opportunities to engage with the public and our patients – this is your BRC o Help and advice in designing our research projects o Help and advice in producing appropriate communications with patients and the public o Help in developing better ways to communicate our research results and its impact o Help with media work o Help in getting more people involved in research • Contact Rosamund Yu Telephone: 020 7679 6166 Email: rosamund.yu@ucl.ac.uk Website: www.uclhospitals.brc.nihr.ac.uk
www.uclhospitals.brc.nihr.ac.uk
NIHR University College London Hospitals BRC in the Media http://www.bbc.co.uk/news/health-22812477
NIHR University College London Hospitals BRC in the Media http://www.bbc.co.uk/news/health-23312712
University College London Hospitals NIHR Biomedical Research Centre Biomedical Research Centre Summary • Partnership between UCL and the NHS (UCL Hospitals) • Translating Discovery into patient care: Complex Phenotyping, Early Phase Evaluation (I/II) and Evaluating Mechanisms of Disease (II-IV); • Partnership with UCLPartners – Adoption and Implementation at scale (III/IV); • A strong spirit of Innovation and Entrepreneurship; • A new culture of Collaboration and Partnership with industry – creating health and wealth – a unique opportunity; • Aligned and explicitly supported by UK Government strategy and funding – coordinated by the NIHR Office for Clinical Research Infrastructure (NOCRI ) nihr.ac.uk/infrastructure/nocri
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