Improved dose determination for Molecular Radiotherapy Andrew - PowerPoint PPT Presentation

Improved dose determination for Molecular Radiotherapy Andrew Robinson Dave Cullen Nuclear Physics Group, The University of Manchester Jill Tipping David Hamilton The Christie NHS Foundation Trust

Christie Research Huddle – 07/04/14

Christie Research Huddle – 07/04/14

Scatter Correction Triple Energy Window Sensitivity Factor Christie Research Huddle – 07/04/14

TRT with 177 Lu-DOTATATE 177 Lu: t 1/2 = 6.647 days ( 177 Lu) = 100% b beta ( 177 Hf) = 18% b gamma EM SC RAW TEW 5000 MBq 300 MBq Day 0 Day 6 Christie Research Huddle – 07/04/14

Simulation - Camera ● Collimator and touch plate ● Crystal ● PMT array ● Back compartment ● Shielding ● Bed and mattress Christie Research Huddle – 07/04/14

Simulation - Phantom Christie Research Huddle – 07/04/14

Simulation - Sources 99m Tc T 1/2 = 6.0 hrs B gamma = 0.999963 (140 keV) B beta = 0.000037 (112 keV mean energy) 177 Lu T 1/2 = 6.647 days B gamma = 0.236 (113, 208 keV daughter nucleus) B beta = 1.000 (134.2 keV mean energy) 90 Y T 1/2 = 64.053 hrs B gamma = 0.000115 (1.76 MeV daughter nucleus) B beta = 1.000 (933 keV mean energy) B positron = 0.000032 (daughter nucleus)

Simulation - Sources 99m Tc T 1/2 = 6.0 hrs B gamma = 0.999963 (140 keV) B beta = 0.000037 (112 keV mean energy) 177 Lu T 1/2 = 6.647 days B gamma = 0.236 (113, 208 keV daughter nucleus) B beta = 1.000 (134.2 keV mean energy) 90 Y T 1/2 = 64.053 hrs B gamma = 0.000115 (1.76 MeV daughter nucleus) B beta = 1.000 (933 keV mean energy) B positron = 0.000032 (daughter nucleus)

Cluster  Gate 6.1  Gate 6.2  Gate 7.0(beta)  Geant 4.9.4  Geant 4.9.5  Geant 4.9.6  Geant 4.10 (MT) Christie Research Huddle – 07/04/14

Cluster x2 Xeon E5520 @ 2.27GHz nucpc76.ph.man.ac.uk 8 Cores (16 with Hyper Threading) FASTPC2 x2 Xeon E5620 @ 2.4GHz nucpc90.ph.man.ac.uk 8 Cores (16 with Hyper Threading) FASTPC3 x2 Xeon E5620 @ 2.4GHz nucpc91.ph.man.ac.uk 8 Cores (16 with Hyper Threading) FASTPC4 264 cores x2 Xeon E5620 @ 2.4GHz nucpc96.ph.man.ac.uk 8 Cores (16 with Hyper Threading) FASTPC5 76 TB storage x4 AMD Opteron 6176 @ 2.3GHz nucpc97.ph.man.ac.uk 48 Cores FASTPC6 nucpc108.ph.man.ac.uk x4 AMD Opteron 6274 @ 2.2GHz FASTPC8 64 Cores nucpc115.ph.man.ac.uk x4 AMD Opteron 6274 @ 2.2GHz FASTPC9 64 Cores nucpc116.ph.man.ac.uk x4 AMD Opteron 6274 @ 2.2GHz FASTPC10 64 Cores

Improved Scatter Correction “Is it possible to have a scatter correction method which provides accurate quantification and improved image quality which is applicable in ALL conditions? Quantification Image Quality

Triple Energy Window Correction Infinia Hawkeye Simulation (all events) Unscattered events ICMP 2013 – Brighton (4 th September)

Triple Energy Window Correction Infinia Hawkeye Simulation (all events) Unscattered events EM1 EM2 Scat K. Ogawa et al, IEEE Trans. Med. Imaging, 10, 408-412 (1991)

Pre reconstruction TEW Whole Image Christie Research Huddle – 07/04/14

Pre reconstruction TEW Whole Image Christie Research Huddle – 07/04/14

3D Printing Use 3D printing to produce phantom inserts based on CT images. ● Sensitivity Factor ● Partial Volume effects ● Patient specific measurements Christie Research Huddle – 07/04/14

3D Printing Christie Research Huddle – 07/04/14

3D Printing Christie Research Huddle – 07/04/14

3D Printing Christie Research Huddle – 07/04/14