See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/6277612 Hematological presentation in systemic lupus erythematosus and its relationship with disease activity Article in Hematology (Amsterdam, Netherlands) · June 2007 DOI: 10.1080/10245330701214145 · Source: PubMed CITATIONS READS 42 207 3 authors: Esin Beyan Cengiz Beyan University of Health Science, Kecioren Training and Research Hospital Ufuk Üniversitesi 109 PUBLICATIONS 387 CITATIONS 217 PUBLICATIONS 1,755 CITATIONS SEE PROFILE SEE PROFILE Mustafa Turan Gulhane Military Medical Academy 50 PUBLICATIONS 1,220 CITATIONS SEE PROFILE All content following this page was uploaded by Cengiz Beyan on 16 May 2014. The user has requested enhancement of the downloaded file.
This article was downloaded by:[ANKOS Consortium] On: 21 January 2008 Access Details: [subscription number 772814176] Publisher: Informa Healthcare Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK Hematology Publication details, including instructions for authors and subscription information: http://www.informaworld.com/smpp/title~content=t713643071 Hematological presentation in systemic lupus erythematosus and its relationship with disease activity Eśin Beyan a ; Cen?iz Beyan b ; Mustafa Turan c a Department of Internal Medicine, Numune Education and Research Hospital, Ankara, Turkey b Department of Hematology, Gulhane Military Medical Academy, Etlik, Ankara, Turkey c Department of Medical Ecology and Hydroclimatology, Gulhane Military Medical Academy, Ankara, Turkey Online Publication Date: 01 June 2007 To cite this Article: Beyan, Eśin, Beyan, Cen?iz and Turan, Mustafa (2007) 'Hematological presentation in systemic lupus erythematosus and its relationship with disease activity', Hematology, 12:3, 257 - 261 To link to this article: DOI: 10.1080/10245330701214145 URL: http://dx.doi.org/10.1080/10245330701214145 PLEASE SCROLL DOWN FOR ARTICLE Full terms and conditions of use: http://www.informaworld.com/terms-and-conditions-of-access.pdf This article maybe used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material.
Hematology , June 2007; 12(3): 257–261 Downloaded By: [ANKOS Consortium] At: 07:38 21 January 2008 Hematological presentation in systemic lupus erythematosus and its relationship with disease activity ´IN BEYAN 1 , CENG ´ IZ BEYAN 2 , & MUSTAFA TURAN 3 ES 1 Department of Internal Medicine, Numune Education and Research Hospital, Ankara, Turkey, 2 Department of Hematology, Gulhane Military Medical Academy, Etlik, 06010 Ankara, Turkey, and 3 Department of Medical Ecology and Hydroclimatology, Gulhane Military Medical Academy, Ankara, Turkey (Received 5 September 2006; accepted 1 December 2006) Abstract Abnormalities of hematological system are very common in systemic lupus erythematosus (SLE). The aim of the study is to evaluate hematological findings in patients with SLE at the time of referral and their relationship with disease activity and organ involvement. The study was carried consecutive 115 patients, including 20 males and 85 females. Most of the cases had anemia at the time of presentation due to various etiologies. Anemia of chronic disease was seen in 46% and it was the most common encountered picture. The rate of hemolytic anemia was 28%, and Coombs’ positivity rate was 22% among our patients. Leukopenia ( , 4.0 £ 10 9 /l), neutropenia ( , 1.8 £ 10 9 /l), and lymphopenia ( , 1.5 £ 10 9 /l) rates were 57, 20, and 82%, respectively. Thrombocytopenia was seen in 40% for , 150 £ 10 9 /l, 26% for , 100 £ 10 9 /l, and 8% for , 50 £ 10 9 /l. Of our patients, 10% had antiphospholipid syndrome (APS) at the time of diagnosis. Increased fibrinogen levels were observed in 35% without relating to disease activity. The rates of C3 and C4 hypocomplementemia were 86 and 64%, respectively, and both are closely correlated with the disease activity. Moreover, C3 hypocomplementemia was more prominent in cases with renal or serosal involvement. Leukopenia and hyperfibrinogenemia were more common in patients with skin/mucosal involvements. C3 hypocomplementemia, APS and elevated IgG levels were more common in our patients with renal involvement. SLE should be kept in mind while evaluating patients with mentioned hematological findings, especially in those with accompanying organ involvements. Keywords: Anemia, blood cells, leukopenia, lupus erythematosus, systemic, thrombocytopenia Introduction treated for SLE in our center. The mean age of the patients was 28.94 ^ 8.46 years (mean ^ SD) (range Systemic lupus erythematosus (SLE) is a chronic 16–56). All patients were fulfilled the American inflammatory disease, which can affect the skin, joints, College of Rheumatology (ACR) 1982 revised criteria kidneys, lungs, nervous system, serous membranes for the classification of SLE [1]. The mean disease age and/or other organs of the body. Abnormalities of of the patients (duration between the first symptom/ hematological system are very common in SLE. sign occur and the diagnosis date) was 1 year (range: 1 The aim of the present study is to determine week–8 years). hematological disturbances in patients with SLE at the The systemic lupus erythematosus disease activity time of referral and their relationship with disease index (SLEDAI) was developed by the consensus of activity and organ involvement. experts as a global assessment of lupus disease activity [2]. Evaluation of SLE disease activity was based on Methods the SLEDAI. According to SLEDAI scores, SLE The study was carried on a group of consecutive 115 patients were divided into two groups: Those with patients, including 20 males and 85 females, who were SLEDAI scores # 10 and those with SLEDAI scores Correspondence: C. Beyan, Department of Hematology, Gulhane Military Medical Academy, Etlik, 06010 Ankara, Turkey. Tel: 90 312 304 41 01. Fax: 90 312 304 41 00. E-mail: cbeyan@yahoo.com ISSN 1024-5332 print/ISSN 1607-8454 online q 2007 Informa UK Ltd. DOI: 10.1080/10245330701214145
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