GWG TRAN Recommendations Gil R Sambrano Vice President of - PowerPoint PPT Presentation

Nov 30, 2023 •32 likes •152 views

MISSION GWG TRAN Recommendations Gil R Sambrano Vice President of Portfolio Development and Review California Institute for Regenerative Medicine October 18, 2018 1 Funding Opportunities Approved New Single Product Pre-IND Meeting

MISSION GWG TRAN Recommendations Gil R Sambrano Vice President of Portfolio Development and Review California Institute for Regenerative Medicine October 18, 2018 1
Funding Opportunities Approved New Single Product Pre-IND Meeting Therapy Idea Candidate or Equivalent
CIRM Translation Research Program (TRAN) Objective To support promising stem cell-based projects that accelerate completion of translational stage activities necessary for advancement to clinical study or broad end use.
What qualifies for TRAN? Projects that propose a candidate: § Therapeutic (TRAN 1) § Diagnostic (TRAN 2) § Medical device (TRAN 3) § Tool (TRAN4)
CIRM Translation Program Prototype with Single candidate Prototype with proof of Readiness (Input) w/disease proof of concept modifying activity concept TRAN2/3: TRAN1: TRAN4: Tool Project Diagnostic/Device Therapeutic Design Transfer Completed Pre- Completed Pre- Sub/IDE Mtg or to Expected Outcome IND Mtg CLIA Manufacturing
Review Criteria ü Does the project hold the necessary significance and potential for impact? ü Is the rationale sound? ü Is the project well planned and designed? ü Is the project feasible?
Scoring System § Score of “85-100” Recommended for funding, if funds are available § Score of “1-84” Not recommended for funding Applications are scored by all scientific members of the GWG with no conflict. The median of all individual GWG scores determines final score.
GWG Recommendations Number of Total Applicant Funds Apps Request Available Recommended for funding 3 $13,478,286 $15,842,345 Score 85-100 Not recommended for funding 9 Score 1-84 For each award, the final award amount shall not exceed the amount approved by the ICOC Application Review Subcommittee and may be reduced contingent on CIRM’s assessment of allowable costs and activities.
Overview of Recommended Applications
TRAN1-11265 TITLE: Clinical Translation of Autologous Regenerative Cell Therapy for Blindness DISEASE INDICATION: Retinal diseases PRODUCT TYPE: Cell therapy APPROACH: Autologous iPSC-derived retinal progenitor cell transplant
TRAN1-11259 TITLE: Developing engineered autologous leukemia vaccines to target residual leukemic stem cells DISEASE INDICATION: Acute myelogenous leukemia (AML) PRODUCT TYPE: Biologic APPROACH: Autologous genetically-modified AML vaccine targeting cancer stem cells
TRAN1-11300 TITLE: A purified allogeneic cell therapy product for treatment of Dry Age-related Macular Degeneration DISEASE INDICATION: Age-related macular degeneration PRODUCT TYPE: Cell therapy APPROACH: Allogeneic neural stem cell transplant

Recommend

GWG TRAN Recommendations Gil R Sambrano Vice President of Portfolio Development and Review

MISSION GWG TRAN Recommendations Gil R Sambrano Vice President of Portfolio Development and Review California Institute for Regenerative Medicine May 24, 2018 1 Funding Opportunities Approved New Single Product Pre-IND Meeting Therapy

421 views • 13 slides

Recommendations by the Expert Group on European Corporate Bond Markets Le Quang tran Van, French

Recommendations by the Expert Group on European Corporate Bond Markets Le Quang tran Van, French Association of Large Companies (Afep) Christoph Hock, Union Investment Public Hearing on Corporate Bond markets, Brussels, 24 November 2017 Making

258 views • 15 slides

FNFNES Recommendations Recommendations from the FNFNES are currently being finalized,

FNFNES Recommendations Recommendations from the FNFNES are currently being finalized, subject to feedback received at this Forum. A number of recommendations are currently being considered. Recommendations (1/3) 1. The authors of

220 views • 5 slides

4/17/20 Design, Analysis, and Assessment of Learning Workgroup Recommendations Recommendations

4/17/20 Design, Analysis, and Assessment of Learning Workgroup Recommendations Recommendations Submitted April 2020 1 DNA Workgroup Recommendations Goal Statement Main Recommendations Curriculum Development Recommendations

417 views • 5 slides

Answer Set Programming and Human-Robot Interactions: Challenges and Opportunities Tran Cao Son

Answer Set Programming and Human-Robot Interactions: Challenges and Opportunities Tran Cao Son Computer Science, New Mexico State University, Las Cruces, NM (Joint work with: Chitta Baral, Michael Gelfond, and Arindam Mitra) Dresden 2016 Tran

755 views • 44 slides

PHS Senior Class Presentation for Families A guide by Minh Tran Welcome & Introductions

PHS Senior Class Presentation for Families A guide by Minh Tran Welcome & Introductions Counselors Randyl Barrozo Erica Linares Teresa Martinez Dr. Allison Steppes Minh Tran What Should I Do Now? Meet with your Counselor! Review

587 views • 19 slides

Implementation Plan for ALL (27) Recommendations, including 2 IOC-specific RECOMMENDATIONS ON

RECOMMENDATIONS ON GOVERNANCE Extensive discussions, both in session and in the intersessional periods Consultations with Group 2 Co-Chairs 2018 Executive Council: Implementation Plan for ALL (27) Recommendations, including 2

67 views • 3 slides

DDSN Recommendations 1 Department of Disabilities and Special Needs Recommendations to the House

DDSN Recommendations 1 Department of Disabilities and Special Needs Recommendations to the House Legislative Oversight Committee, Healthcare and Regulatory Subcommittee Interim State Director Pat Maley August 30, 2018 DDSN Recommendations 2

301 views • 28 slides

Unsupervised Neural Hidden Markov Models Ke Tran 1 , Yonatan Bisk , Ashish Vaswani 2 , Daniel

Unsupervised Neural Hidden Markov Models Ke Tran 1 , Yonatan Bisk , Ashish Vaswani 2 , Daniel Marcu and Kevin Knight USC Information Sciences Institute 1 Univ of Amsterdam, 2 Google Brain I am not Ke Tran https://github.com/ketranm/neuralHMM

300 views • 27 slides

The Council should consider these recommendations and data from the resident surveys as it

SBD RECOMMENDATION OVERALL IMPRESSIONS AND RECOMMENDATIONS The following recommendations are based on responses to a survey that solicited resident input on creating a SBD and on the committees own educational process and advice. The committee

168 views • 16 slides

MenACWY-TT (MenQuadfi): Evidence to Recommendations Framework (EtR), Grading of Recommendations,

National Center for Immunization & Respiratory Diseases MenACWY-TT (MenQuadfi): Evidence to Recommendations Framework (EtR), Grading of Recommendations, Assessment, Development, and Evaluation (GRADE), and Workgroup Considerations Lucy

588 views • 48 slides

Ph Phas ase e 2b 2b tr trial ial of of A AMT MT-06 061 1 (AA (AAV5 V5-Pad adua ua hF

Ph Phas ase e 2b 2b tr trial ial of of A AMT MT-06 061 1 (AA (AAV5 V5-Pad adua ua hF hFIX IX va varian riant): t): Tran ansla slation tion into into Human Humans s of of an an Enh Enhan ance ced d Gen Gene e Tran

238 views • 8 slides

The Tr Tran e Sp Spiritual Cor ansfor sformation of of tion ore e

Irene Alexander PACFA 2016 The Tr Tran e Sp Spiritual Cor ansfor sformation of of tion ore e http://wonderfulengineering.com/35-hd-galaxy-wallpapers-for-free-download/

981 views • 59 slides

911/MPD Workgroup Recommendations 1 Agenda Background Findings Recommendations

CITY OF MINNEAPOLIS 911/MPD Workgroup Recommendations 1 Agenda Background Findings Recommendations Appendix The design process State statutes 911/MPD Data 2 Background 3 Staff direction Directing the City

1.28k views • 61 slides

IA 2015 Recommendations December 16 th 2015 IA Recommendations 1 & 2 EITI Standard Requirement

IA 2015 Recommendations December 16 th 2015 IA Recommendations 1 & 2 EITI Standard Requirement 5.3 (f): The Independent Administrator may wish to make recommendations for strengthening the reporting process in the future... Reporting

108 views • 9 slides

ROLLING FORK, MS Key Recommendations Top 9 QI Recommendations Warm handoffs/ bedside

ROLLING FORK, MS Key Recommendations Top 9 QI Recommendations Warm handoffs/ bedside reporting Leadership rounding White Boards Quality Scorecard Discharge follow up phone calls Admission/Discharge Folders

325 views • 13 slides

Locks and Crosses in the Foreign-Exchange Electronic Communication Networks Ly Tran Last

Motivation Dataset Three Hypotheses on the Origin of Locks & Crosses Conclusion Locks and Crosses in the Foreign-Exchange Electronic Communication Networks Ly Tran Last updated: Apr 30, 2015 Ly Tran Locks and Crosses 1/25 Motivation

533 views • 26 slides

2003 Retention Task Force Recommendations Recommendation Recommendations Current Status of

2003 Retention Task Force Recommendations Recommendation Recommendations Current Status of Programs/Services That Address the Recommendations of the Task Theme Force Establish First Year Academic Affairs/Enrollment Services created Office of

51 views • 3 slides

ROADSIDE ADVERTISING & ROAD SAFETY 10 recommendations For the full recommendations see

ROADSIDE ADVERTISING & ROAD SAFETY 10 recommendations For the full recommendations see https://bit.ly/2HgoJgE The ADVERTS project was funded under the CEDR Transnational Road Research Programme - Call Safety 2016. 1 Dont cause confusion

248 views • 11 slides

The Validity of Selection Procedures Joey Tran, Casey Procopio, Patrick Catalan, Situation

The Validity of Selection Procedures Joey Tran, Casey Procopio, Patrick Catalan, Situation Assessment as an Ignored Factor in the Behavioral Consistency Paradigm Underlying the Validity of Personnel Selection Procedures -Joey Tran Key Terms

244 views • 22 slides

Recommendations weight is one of the most important things you can do to reduce chronic

9/9/2015 Nutrition and Objectives Bone Marrow Failure Healthy eating recommendations Joanna M. Myers Casale, RD, CSO Side-effect management myerscasale-joanna@cooperhealth.edu Food safety Supplements Questions General Recommendations Be

168 views • 5 slides

Recommendations Survey June 4, 2020 Recap of Policy Recommendations survey Policy

California VGI Working Group Workshop 7 Data analysis of Policy Recommendations Survey June 4, 2020 Recap of Policy Recommendations survey Policy Recommendations in the VGI Working Group 109 policy recommendations, with detailed input

255 views • 8 slides

Cyber-Physical Systems and Mixed Simulations Tran Van Hoang Supervisor: Professor Bernard Pottier

Cyber-Physical Systems and Mixed Simulations Tran Van Hoang Supervisor: Professor Bernard Pottier University of Western Brittany June 23, 2015 Tran Van Hoang (UBO) June 23, 2015 1 / 23 Contents Simulating and monitoring the environment 1

619 views • 23 slides

guideline recommendations Instructions for guideline translators Recommendations form the core of

How to identify and interpret ERBP guideline recommendations Instructions for guideline translators Recommendations form the core of any clinical practice guideline, and therefore require special attention during the process of translation.

523 views • 14 slides