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Cardiac surgery: where are we going? Ottavio Alfieri S.Raffaele University Hospital,Milan Senning Lecture, Zurich, June 12 th 2015 1 Texas Heart Institute, 1970 The Pioneering Phase of Cardiac Surgery <1950 1953 1960 1967 1969

  1. Cardiac surgery: where are we going? Ottavio Alfieri S.Raffaele University Hospital,Milan Senning Lecture, Zurich, June 12 th 2015 1

  2. Texas Heart Institute, 1970

  3. The Pioneering Phase of Cardiac Surgery <1950 1953 1960 1967 1969 Congenital Valve Surgery CABG CPB TAH and Open Heart HTx Valve (Closed Heart ) 3

  4. Åke Senning (1915-2000)

  5. Major contributions of Prof. Senning to the treatment of heart diseases • 1951:Pump oxygenator for CPB (experimental) • 1953:Open heart surgery:removal of mixoma • 1957:Atrial inversion operation for TGA • 1958:First implantable pace-maker • 1958:Autogenous fascia lata valve for AVR • 1969:First heart transplant in Switzerland • 1977:Supporting Andreas Gruntzig in first percutaneous coronary angioplasty

  6. Since 1970……. up to now Improvements and refinements Consolidation and validation Evolution and transformation 6

  7. Future:where are we going ? „The trouble with the future is that it‘s so much less knowable than the past.“ John Lewis Gaddis, The Landscape of History 7

  8. CABG will be history in 2010 (Predictions of the year 2000)

  11. o Joint Cardiology (ESC) and Cardiac Surgery (EACTS) o 25 members from 13 European countries (reflects the ‘Heart Team’) • 9 non interventional cardiologists, • 8 interventional cardiologists, • 8 cardiac surgeons o Extensively reviewed by external referees

  12. Joint ESC/EACTS Guidelines for Myocardial Revascularization 2010 Table 9. Indications for CABG versus PCI in stable patients with lesions suitable for both procedures and low predicted surgical mortality • In the most severe patterns of CAD, CABG appears to offer a survival advantage as well as a marked reduction in the need for repeat revascularisation.

  13. The certainties 13

  14. Bulk of Population Growth The Economist, May 14 th 2011

  15. Areas of Activity of Cardiac Surgery HF Structural and Heart Arrythmias Disease Athero- sclerosis

  16. SURGERY CARDIOLOGY TP INVASIVENESS

  17. Patient Centered Care • Team work: Multidisciplinary team of specialists choosing the best treatment modality. • Individualized treatment : – Treatment modality chosen according to risk assessment, clinical characteristics , anatomical considerations, whishes of the individual patient

  18. The likelihoods 18

  19. Coronary Surgery Complexity Beating Heart No touch Total Arterial Skeletonization BIMA LIMA Time

  20. JTCVS, 2015

  21. 1 st Hybrid procedure (12/29/04 )

  22. MINIMALLY INVASIVE LIMA on LAD RIMA OM1 Distals via small thoracotomy Robotic assist IMA harvest LAD

  23. MINIMALLY INVASIVE CABG: COMPLETE ARTERIAL REVASCULARIZATION VIA A SMALL THORACOTOMY RIMA LIMA LIMA RIMA OM1 LAD OM1 LAD Distal anastomoses via small thoracotomy Predischarge CT angiography Postoperative angiography

  24. Sintax score 38

  25. PCI Sintax score 38

  26. Final, 13 m. after the procedure

  27. Heart Team: Not optimal candidate for surgery, diffuse LAD disease, a staged PCI was planned Xience Prime 2.25/18 mm Predilation SC 2.0/30 mm Xience Prime 2.25/12 mm

  28. PROspective Global REgiStry for the Study of CTO interventions 1/2012 to 2/2014 • Appleton Cardiology, WI n=632 • Dallas VAMC/UTSW, TX Technical success: 92.4% • Peaceheath Bellingham, WA Major complications: 1.9% • Piedmont Heart Institute, GA •St Luke’s Mid America Heart Success similar w/o and with prior CABG (93.7% vs. 90.0%) Institute, MO • Torrance Medical Center, CA Successful technique 100 Antegrade Antegrade DR 80 Retrograde 65 60 % 44 37 40 20 0 Techniques Used Christopoulos, Karmpaliotis, Alaswad, Wyman, Lombardi, Grantham, Thompson, Brilakis et al, JIC 2014

  29. only 8 operators performed 50 or more CTO PCI per year. Brilakis et al, TCT 2014 and JACC Cardiovasc Intv 2015

  30. Aortic Valve Implantation The Evolving Process Conventional through midline sternotomy Surgical through minimal incision Invasiveness On pump, arrested heart sutureless valve replacement Surgical apico-aortic valved conduit Transaortic delivery Transapical delivery TAVI Transaxillary delivery Transcarotid delivery Percutaneous transfemoral

  31. AHA/ACC TAVI Guidelines - 2014 Class I: • Heart Valve Team should collaborate on decisions • Pts not suitable for AVR and survival > 12 mos Class IIa: • Reasonable alternative to surgical AVR in high surgical risk pts

  33. Published April 2012

  34. Published April 2012

  35. US CoreValve High-Risk Trial

  37. TAVI Technologies in randomized trials First Generation Devices Medtronic CoreValve Edwards Lifesciences

  38. Next Generation TAVR Systems New Self-Expanding TAVI Systems EVOLUT R PORTICO ACURATE ENGAGER (Medtronic) (St. Jude) (Symetis) (Medtronic)

  39. Next Generation TAVR Systems Not All New TAVI Systems are Self-Expanding Designs Direct Flow: SAPIEN 3: Lotus : Jena Valve : Polyester fabric Nitinol-based, balloon exp Nitinol wire cuff with two frame, bovine positioning (4 sizes), cobalt inflatable rings; feelers and frame; bovine tissue valve; positioning wires clipping tissue valve; outer PU skirt; for placement; outer skirt; mechanical mechanism; bovine tissue porcine aortic precise expansion and valve locking root valve positioning

  40. …Expanding TAVI…

  41. PARTNER 2 and SURTAVI ongoing

  42. Alec Vahanian MD, Bichat Hospital, Paris, University Paris VII alec.vahanian@bch.aphp.fr Performance Safety (mortality ,stroke) Vascular complications Perivalvular leaks Conduction defects Durability

  43. Alec Vahanian MD, Bichat Hospital, Paris, University Paris VII alec.vahanian@bch.aphp.fr Surgical AVR will be limited to contraindications to and to pts requiring combined cardiac or aortic surge

  44. Sutureless aortic prosthesis Medtronic 3f Enable Sorin Perceval S Edwards Intuity

  45. THE THE EV EVOL OLVING VING APPR APPROACH CH TO O MITRA MITRAL L VAL ALVE VE INTER INTERVENTIONS VENTIONS Sternotomy Minimally Invasive Percutaneous Robotic

  46. Percutaneous Devices Landscape 2010/2015  Accucinch*  Edge-to-Edge  ReCor (US)*  MitraClip*  Quantum Cor (RF)  Valtech Cardioband  Edwards Mobius  Micardia enCor  Coronary sinus  Mitral valve replacement annuloplasty  • EndoValve  Cardiac Dimensions Carillon*  • CardiAQ  Edwards Monarc  • Valtech Cardiovalve  Viacor PTMA*  • ValveXchange  Cerclage annuloplasty  Chordal shortening and  Indirect annuloplasty other  Ample PS3  Cardiosolutions  St. Jude AAR  Mitra-Spacer*  Mycor i-Coapsys  NeoChord  Direct annuloplasty  Valtech VChordal  Mitralign*  QuantumCor  MiCardia ebCor *in humans

  48. Mitra Clip

  49. Direct annuloplasty the only approach with a proven surgical background Mitralign GDS Valtech Bident Accucinch Cardioband • Arterial access • Arterial access • Venous access • Transannular • Subannular cinching • Annular fixation cinching

  50. Transcatheter Mitral Valve Implantation • Few extreme human cases with high acute mortality • Rapid developing field • • Potential advantages : Open issues: – easier – Safety – one device for all – PV leaks – reproducible – Hemodynamics (vortex) – predictable result – Durability

  51. MV Replacement Transcatheter mitral implant devices Company product access status Caisson Caisson TMR TF preclinical CardiaQ TMVI-TA TF / TAp clinical Edwards Fortis TAp / TF clinical Emory U MitraCath NA Early develop. HighLife HighLife MVR TAt preclinical Invalve Invalve NA IP Medtronic TMVR TAt / TF preclinical Micro Interv. Devices Endovalve TA NA preclinical MitrAssist Mitrassist valve NA preclinical Mitralix MAESTRO NA Early develop. MITRICARES Mitricares NA IP NCSI NAVIGATE TMVR TAt /TF clinical Neovasc Tiara TA / TF clnical Tendyne Tendyne Lutter TA clinical Twelve TMVR NA IP ValtechCardio Cardiovalve TF preclinical

  52. Fully Percutaneous Mitral Repair

  53. The complementary role of transcatheter techniques • Stand-alone annuloplasty : early treatment FMR /symmetric tethering • Stand-alone Mitraclip : FMR with annuloplasty asymmetric tethering (IMR) • Stand-alone Mitraclip : DMR with little annular dilatation • Combined Annuloplasty and MitraClip : DMR with important annular dilatation and advanced replacement mitraclip FMR • MV Replacement : advanced organic MR and advanced FMR /

  54. HF: an evergrowing problem • Approximately 1-2% of adut population in developed countries. • Prevalence rising to ≥10% among persons 70 years of age or older. (ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. EHJ 2012; 33:1787 – 1847) Prevalence of HF by gender and age from 2003 to 2006. Writing Group Members et al. Circulation 2010; 121:e46-e215. Hospital discharge for HF from 1979 to 2006. Writing Group Members et al. Circulation 2010; 121:e46-e215.

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