Global Health Infectious Disease Research Program John H Adams, PhD - PowerPoint PPT Presentation

Global Health Infectious Disease Research Program John H Adams, PhD Distinguished USF Health Research Professor 21 st Century World Class Scholar, 2007 Chair, USF Research Council USF College of Public Health Department of Global Health

2013-2014 Research Program 2 – USF Undergraduate • Honors Students 4 – Doctoral • Candidates/2 PhDs awarded 1 – MSPH/MPH students • 5 – PhD/MD level scientists • 6 – Full-time Research Staff • 3 – Part-time • Staff/Research Assistants

Functional genomics for drug discovery Genetics + computational biology High content image analysis • Goal: improve use of current drugs and develop new types of antimalarial drug • Obstacle: modern genetics is difficult with malaria parasites Flow cytometric In silico drug discovery Quantitative analysis • A translational study that combines genetics, computational biology, and medicinal chemistry • Funding NIH grants, MMV; $2,266,499: R01AI094973, R21AI098098, R21AI105328 • Key USF faculty links: Dennis Kyle, Rays Jiang, Bill Baker • US Patent 7932088 (April 26, 2011 ) awarded for piggyBac transposon use in malaria parasites

Functional genomics for drug discovery data link knowns and unknowns Simple pairwise comparisons Multipairwise comparisons Clusters functionally link genes & drugs

Functional genomics for drug discovery How results are used to identify drug targets Identify targets linked to drug mode of action

Functional genomics for drug discovery Define chemotype of unknown drugs How results are used to identify new drugs

Enabling Technologies: ‘Lab -on-a- Chip’ Liver Model • Goal: provide in vitro screening platform for antimalarial drug discovery research. • Obstacles: human liver cells are difficult to grow Basic research of parasite biology + advanced bioengineering & maintain in culture; requires sophisticated insectary laboratory • A translational study that combines parasitology, drug discovery, and bioengineering. Collaboration with Drs. Dennis Kyle (USF) and Wajeeh Saadi USF-Draper Laboratories. Grant support from BMGF $11,523,029/5years