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Evolving adaptive coincidence-detecting neurons W. Garrett Mitchener College of Charleston January 10, 2015 W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 1 / 23 Neurons & action potentials Neurons and action potentials

  1. Evolving adaptive coincidence-detecting neurons W. Garrett Mitchener College of Charleston January 10, 2015 W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 1 / 23

  2. Neurons & action potentials Neurons and action potentials W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 2 / 23

  3. Neurons & action potentials synapse dendrites axon soma W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  4. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + K + K + Na + Na + Na + K + K + K + K + Na + Na + Na + K + K + K + K + K + Na + Na + K + K + K + Na + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + K + K + Na + Na + Na + K + K + K + K + Na + Na + Na + K + K + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  5. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + K + K + Na + Na + Na + Na + K + K + K + K + Na + Na + K + K + K + K + K + Na + Na + Na + K + K + K + Na + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + K + K + Na + Na + Na + Na + Na + K + K + K + K + Na + Na + Na + K + K + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  6. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + K + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + K + Na + K + K + Na + Na + Na + Na + K + K + K + Na + Na + K + K + K + K + Na + Na + Na + K + K + K + Na + K + K + K + K + Na + K + Na + Na + K + K + K + K + K + K + K + K + K + Na + K + Na + K + K + K + K + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + Na + Na + Na + Na + Na + K + K + K + K + Na + Na + K + Na + Na + Na + K + Na + Na + K + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  7. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + K + Na + Na + Na + Na + Na + Na + K + Na + Na + K + Na + Na + Na + Na + Na + K + K + Na + Na + Na + Na + K + K + K + Na + K + K + K + K + Na + Na + Na + K + K + K + K + Na + K + K + K + K + Na + K + Na + K + K + K + K + K + K + K + Na + Na + K + Na + K + Na + Na + Na + Na + Na + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + Na + Na + K + K + K + K + K + K + K + Na + K + K + Na + K + K + K + K + K + Na + Na + K + Na + Na + Na + Na + K + K + Na + K + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  8. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + K + Na + Na + Na + Na + Na + Na + K + Na + Na + K + Na + Na + Na + Na + Na + K + K + Na + Na + Na + Na + K + K + K + K + Na + K + K + K + K + Na + Na + Na + K + K + K + K + K + Na + K + K + K + Na + K + Na + K + Na + Na + K + K + K + K + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + K + K + K + K + K + K + Na + Na + Na + K + K + K + K + K + K + K + K + K + Na + K + K + K + K + K + K + K + Na + K + K + Na + Na + Na + Na + K + K + K + K + K + K + Na + Na + Na + Na + Na + Na + Na + Na + K + K + K + Na + Na + K + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  9. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + K + K + Na + Na + Na + Na + Na + K + Na + Na + K + Na + Na + Na + Na + K + K + Na + Na + K + Na + Na + Na + Na + Na + K + K + K + K + Na + Na + Na + K + K + K + Na + Na + Na + K + Na + K + K + K + K + Na + Na + Na + Na + K + Na + Na + K + K + K + K + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + K + K + K + K + K + K + K + K + Na + Na + Na + K + K + K + K + K + K + K + K + K + K + Na + K + K + K + K + K + K + K + Na + K + K + Na + Na + Na + K + K + K + K + K + K + Na + Na + Na + Na + Na + Na + Na + K + K + K + Na + Na + K + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  10. Neurons & action potentials Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + K + K + K + Na + Na + Na + Na + Na + K + Na + Na + K + Na + Na + Na + Na + K + K + Na + Na + K + Na + Na + Na + Na + Na + K + K + K + K + Na + Na + Na + K + K + K + Na + Na + Na + K + Na + K + K + K + K + Na + Na + Na + Na + K + Na + Na + K + K + K + K + Na + Na + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + K + K + K + K + K + K + K + K + Na + Na + Na + K + K + K + K + K + K + K + K + K + K + Na + K + K + K + K + K + K + K + Na + K + K + Na + Na + Na + K + K + K + K + K + K + Na + Na + Na + Na + Na + Na + Na + K + K + K + Na + Na + K + Na + Na + Na + Na + K + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + Na + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 3 / 23

  11. Neurons & action potentials W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 4 / 23

  12. Neurons & action potentials Na + Ca 2+ K + W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 4 / 23

  13. Neurons & action potentials W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 5 / 23

  14. Neurons & action potentials In: ╌╌╌╌┸╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌ Out: ╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌ In: ╌╌╌╌┸╌╌╌╌╌╌┸╌╌╌╌╌╌╌╌ Out: ╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌ In: ╌╌╌╌┸┸╌╌╌╌╌╌╌╌╌╌╌╌╌╌ Out: ╌╌╌╌╌╌┸╌╌╌╌╌╌╌╌╌╌╌╌╌ In: ╌╌╌╌╌╌╌╌╌╌┸╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌┸╌╌╌╌╌╌╌╌┸╌┸╌╌╌╌╌╌ Out: ╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌╌┸╌╌╌╌╌ W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 6 / 23

  15. Utrecht machine Utrecht machine W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 7 / 23

  16. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  17. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  18. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  19. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  20. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  21. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  22. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  23. Utrecht machine Design of discrete biochemistry W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 8 / 23

  24. Utrecht machine Utrecht machine Activation array: A [ p ] = how many molecules of type p Think transcription factors matching promoter A [ 0 ] = 0 pattern in DNA . . . A [ 3 ] = 11 . . . A [ 41 ] = 1 . . . W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 9 / 23

  25. Utrecht machine Utrecht machine Activation array: Input: If input is on then A [ 0 ] = 0 add 8 to A [ 3 ] . . . A [ 3 ] = 11 . . . A [ 41 ] = 1 . . . W. Garrett Mitchener (C of C) Evolving neurons January 10, 2015 9 / 23

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